Multifunctional Lipophobic Polymer Dots from Cyclodextrin: Antimicrobial/Anticancer Laborers and Silver Ions Chemo-Sensor

beta-Cyclodextrin (CD) is currently exploited for the implantation of lipophobic polymer dots (PDs) for antimicrobial and anticancer laborers. Moreover, the PDs were investigated to act as a chemo-sensor for metal detection. The data revealed that under basic conditions, photoluminescent PDs (5.1 nm) were successively clustered with a controllable size at 190 degrees C, whereas under acidic conditions, smaller-sized non-photoluminescent carbon nanoparticles (2.9 nm) were obtained. The fluorescence intensity of synthesized PDs under basic conditions was affected by pH, and such an intensity was significantly higher compared to that prepared under acidic conditions. The PDs were exploited as florescent detectors in estimation of Ag+ ions in aquatic streams. Treatment of Ag+ ion colloids with PDs resulted in fluorescence quenching attributing to the production of AgNPs that approved by spectral studies. The cell viability percent was estimated for Escherichia coli, Staphylococcus aureus, and Candida albicans after incubation with PDs implanted under basic conditions for 24 h. The cell mortality percent was estimated for breast cancer (MCF-7) after incubation with different concentrations of PDs that were implanted under acidic versus basic conditions to show that treatment of the tested cells with 1000 mu g/mL PDs prepared under basic (IC50 232.5 mu g/ mL) and acidic (IC50 88.6 mu g/mL) conditions resulted in cell mortality percentages of 70 and 90%, respectively.

Automated summary

Beta-Cyclodextrin (CD) is used as a carrier for antimicrobial and anticancer polymer dots (PDs), and also studied as a fluorescent sensor for metal detection. The study found that under basic conditions, synthesized PDs formed controllable clusters, while under acidic conditions, smaller non-fluorescent carbon nanoparticles were obtained. Fluorescence intensity of the PDs synthesized under basic conditions was affected by pH, and higher compared to those under acidic conditions. The PDs were also used as fluorescent detectors for silver ions in water.