☆ 4.5 Review

Exploring Monocytes-Macrophages in Immune Microenvironment of Glioblastoma for the Design of Novel Therapeutic Strategies

BRAIN SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Pro- vs. Anti-Inflammatory Features of Monocyte Subsets in Glioma Patients

Natalia Lehman et al.

Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Oncology

Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

Julie J. Miller et al.

Summary: This article discusses the diagnosis and management of IDH-mutant gliomas, as well as new treatment methods and future research directions.

NEURO-ONCOLOGY (2023)

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Article Biotechnology & Applied Microbiology

PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma

Xuya Wang et al.

Summary: This study investigated the prognostic significance of PDPN and its role in the tumor immunosuppressive microenvironment (IME) in glioma. The findings suggest that PDPN overexpression is an independent prognostic indicator and promotes the formation of an immunosuppressive tumor microenvironment through its association with immune checkpoint expression and tumor-associated immune cells.

CANCER GENE THERAPY (2023)

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Review Medicine, Research & Experimental

Monocyte-neutrophil entanglement in glioblastoma

Dinorah Friedmann-Morvinski et al.

Summary: Glioblastoma (GBM) is a highly aggressive and common brain tumor in adults. Recent research has revealed the complexity and heterogeneity of GBM, which consists of various neoplastic and non-neoplastic cell types forming the unique tumor microenvironment (TME). Non-neoplastic cells in the TME, particularly myeloid cells infiltrating from the blood circulation, play a crucial role in promoting tumor growth and invasion, and affect the tumor response to therapies. This review focuses on the interactions between neutrophils, monocytes, and neoplastic cells in the GBM TME, discussing the challenges in targeting these cells and potential therapeutic strategies to improve patient outcomes.

JOURNAL OF CLINICAL INVESTIGATION (2023)

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Article Cell Biology

Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway

Keitaro Kai et al.

Summary: Tumor-associated macrophages/microglia play a significant role in glioblastoma progression, with IL-1 beta potentially promoting glioblastoma growth. IL-1 beta induces the production of IL-6 and CXCL8 through signal transducer and activator of transcription-3 and nuclear factor-kappa B signaling pathways, thereby promoting glioblastoma growth synergistically.

HUMAN CELL (2022)

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Article Oncology

STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death

Janina Remy et al.

Summary: This study reveals an unknown role of STAT3 in sensitizing glioblastoma cells to excessive autophagy and supports the concept of utilizing autophagy and lysosomal membrane permeabilization for glioblastoma therapy.

CANCERS (2022)

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Article Cell Biology

Tumor-associated macrophages related signature in glioma

Lin-Jian Wang et al.

Aging-US (2022)

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Article Biochemistry & Molecular Biology

Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages, and Tumor Microenvironment

Elena Codrici et al.

Summary: This review article focuses on the components of the GBM microenvironment and their roles in tumor development, as well as the immune-related processes that connect different cell types. It also summarizes the current understanding of soluble factors and highlights the dysregulated inflammatory chemokine/specific receptors cascades/networks and their significance in tumorigenesis, cancer-related inflammation, and metastasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Oncology

CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy

Kevin Pan et al.

Summary: CAR immunotherapy has achieved significant progress in hematological malignancies, but faces challenges in solid tumors. CAR NK cells and CAR macrophages have advantages and limitations. Developing CAR macrophages could be a strategy to overcome hurdles associated with CAR therapy in solid tumors.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Nanoparticle Properties Influence Transendothelial Migration of Monocytes

Nahal Habibi et al.

Summary: This study explores the impact of nanoparticle design parameters on monocyte association and monocyte-mediated blood-brain barrier (BBB) transport. The results show that synthetic protein nanoparticles (SPNPs) can promote monocyte-mediated transport across the BBB. RNA-seq analysis suggests that upregulation of migration genes may be involved in increased monocyte migration. These findings highlight the potential of SPNPs as a drug delivery platform for monocyte-mediated BBB transport.

LANGMUIR (2022)

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Article Pharmacology & Pharmacy

Recent advances in glioma microenvironment-response nanoplatforms for phototherapy and sonotherapy

Xuemeng Li et al.

PHARMACOLOGICAL RESEARCH (2022)

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Article Oncology

Therapy-induced shaping of the glioblastoma microenvironment: Macrophages at play

Johanna Erbani et al.

Summary: The interactions between tumor cells and their microenvironment are crucial for cancer progression and treatment response. This review focuses on the distinct microenvironmental niches in glioblastoma and their impact on therapy, particularly the interplay between tumor-associated macrophages and glioblastoma cells within different niches. Understanding the therapy-induced alterations in the glioblastoma microenvironment is essential for identifying targetable pathways and improving clinical outcomes through combination therapies.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Oncology

Tumor-Associated Macrophages in Gliomas-Basic Insights and Treatment Opportunities

Johannes K. Andersen et al.

Summary: Glioma is a group of primary brain tumors, among which glioblastoma is the most malignant one. The glioma microenvironment is dominated by tumor-associated macrophages (TAMs), which are immunosuppressive and hinder treatment effectiveness. Shifting TAMs towards a proinflammatory state through new therapeutic strategies is of great therapeutic interest for glioma treatment.

CANCERS (2022)

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Review Oncology

The Role of Photodynamic Therapy in Triggering Cell Death and Facilitating Antitumor Immunology

Liuchang Tan et al.

Summary: This paper reviews the tumor treatment strategies of photodynamic therapy (PDT) combined with anti-tumor immunotherapy, focusing on the stimulating effect of PDT on tumor immune response and the mechanisms of enhancing efficacy.

FRONTIERS IN ONCOLOGY (2022)

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Article Immunology

Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma

Wenqing Gao et al.

Summary: This study reveals that chemokines, including CCL2, CCL8, CCL18, CCL28, CXCL1, CXCL5, and CXCL13, are highly expressed in glioblastoma and are associated with immune cell infiltration regulation and worse patient outcomes. Among them, CCL18 is identified as a critical driver of GBM malignant behaviors.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Article Cell Biology

In vitro 2D and 3D cancer models to evaluate compounds that modulate macrophage polarization

Natasha Helleberg Madsen et al.

Summary: This study used a 3D multi-cellular tumor spheroid model to test the effects of compounds on monocyte infiltration and polarization in tumor spheroids. The researchers found that a CSF1R inhibitor prevented monocyte infiltration into pancreatic cancer spheroids, while treatment with a CD40 ligand and poly I:C induced M1 macrophage polarization in their models.

CELLULAR IMMUNOLOGY (2022)

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Article Oncology

A Novel EGFRvIII T-Cell Bispecific Antibody for the Treatment of Glioblastoma

Raffaella Iurlaro et al.

Summary: T-cell bispecific antibodies (TCB) are engineered molecules that can bind both the T-cell receptor and tumor-specific antigens, showing potential therapeutic effects for EGFRvIII mutation in glioblastoma (GBM). We designed and developed a novel EGFRvIII-TCB with specificity and potent antitumor activity, promoting T-cell activation and cytokine secretion for tumor cell killing, as well as T-cell recruitment into tumors. In GBM animal models, including humanized orthotopic patient-derived xenograft models, EGFRvIII-TCB induced tumor regression. These results support the clinical testing of EGFRvIII-TCB.

MOLECULAR CANCER THERAPEUTICS (2022)

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Review Biotechnology & Applied Microbiology

Macrophages as tools and targets in cancer therapy

Alberto Mantovani et al.

Summary: This review discusses the molecular mechanisms of macrophage reprogramming in the tumor microenvironment and provides an overview of macrophage-targeted therapies for cancer treatment.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Cell Biology

Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy

Chen Chen et al.

Summary: Researchers have developed a cavity-injectable nanoporter-hydrogel superstructure to prevent relapse of glioblastoma multiforme (GBM). This superstructure introduces glioma stem cell-specific chimeric antigen receptor (CAR) genes into macrophages/microglia, stimulating an antitumor immune response and preventing postoperative relapse.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Review Oncology

Tumor-Treating Fields in Glioblastomas: Past, Present, and Future

Xiaopeng Guo et al.

Summary: Glioblastoma (GBM) is a common malignant primary brain tumor with a low 5-year survival rate. Tumor-treating fields (TTFields) have emerged as the fourth most effective treatment option for GBMs, prolonging patient survival and showing acceptable adverse events. TTFields disrupts cell mitosis, delays DNA repair, enhances autophagy, inhibits cell metabolism and angiogenesis, and limits cancer cell migration. It also strengthens antitumor immunity, increases cell membrane and blood-brain barrier permeability, and disrupts DNA-damage-repair processes. However, the overall acceptance of TTFields in clinical practice is still low. This review provides an updated understanding of the mechanism of action, efficacy, safety, clinical concerns, and future perspectives of TTFields in GBMs.

CANCERS (2022)

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Article Oncology

Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

Agnieszka Chryplewicz et al.

Summary: This study demonstrates the potential of combination therapy targeting different vulnerabilities in the tumor microenvironment to effectively treat glioblastoma.

CANCER CELL (2022)

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Review Biochemistry & Molecular Biology

Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment

Xianghong Zhou et al.

Summary: With the increasing understanding of immunotherapy, current anticancer therapy research is now more focused on the tumor microenvironment (TME). MicroRNAs (miRNAs) play vital roles in regulating genetic information and expression, as well as mediating interactions between tumor cells and components in the TME, such as tumor-associated macrophages (macrophages). These macrophages are abundant in the TME and their polarization directions can either promote or inhibit tumor growth and progression. By regulating macrophage recruitment, infiltration, and polarization, miRNAs can affect various molecular pathways to regulate tumor progression and treatment response. This review discusses in detail the effects of macrophages on tumors and the multifaceted impacts of miRNAs on macrophages. Additionally, it explores the potential clinical applications and prospects of targeted therapy based on miRNAs, novel clinical biomarkers, and drug delivery systems.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Ruixue Bai et al.

Summary: Hypoxia is considered a major target in cancer treatment, as it is a persistent feature in solid tumors and drives cancer malignancy. Tumor-associated macrophages (TAMs) heavily accumulate in hypoxic tumor regions and the interaction between TAMs and hypoxia contributes to increased tumor aggressiveness. Understanding the molecular mechanisms underlying the hypoxia-mediated communication between tumor cells and TAMs can provide insights for developing novel therapeutic strategies.

MOLECULAR CANCER (2022)

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Review Biochemistry & Molecular Biology

The Use of Photodynamic Therapy in the Treatment of Brain Tumors-A Review of the Literature

Dorota Bartusik-Aebisher et al.

Summary: The treatment of neoplastic disease of the brain is a challenge for modern medicine. Photodynamic therapy (PDT) is an efficient and minimally invasive method with no serious side effects. This review explores the potential of PDT in brain tumor treatment and discusses key points from clinical trials.

MOLECULES (2022)

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Article Public, Environmental & Occupational Health

Burden and trends of brain and central nervous system cancer from 1990 to 2019 at the global, regional, and country levels

Yang Fan et al.

Summary: This study investigated the incidence, mortality, disability, and trends in brain and CNS cancers between 1990 and 2019. The results showed that brain and CNS cancers remain a major public health burden, particularly in high-income regions. The global incidence, deaths, and DALYs of these cancers have increased significantly over the past three decades. The global ASIR continued to rise steadily, while the ASMR and age-standardized DALY rate declined.

ARCHIVES OF PUBLIC HEALTH (2022)

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Article Medicine, Research & Experimental

TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling

Peng Peng et al.

Summary: TGFBI, specifically expressed by tumor-associated macrophages (TAMs), plays a role in promoting glioma stem cells (GSCs) maintenance and tumor growth. The exact mechanism involves integrin alpha v beta 5-Src-Stat3 signaling pathway.

THERANOSTICS (2022)

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Article Medicine, Research & Experimental

Tumor Treating Fields dually activate STING and AIM2 inflammasomes to induce adjuvant immunity in glioblastoma

Dongjiang Chen et al.

Summary: TTFields, a novel therapy for GBM and other solid tumors, disrupts mitotic spindle and induces inflammation to exert its anti-tumor effects. The study reveals that TTFields can activate DNA sensors and inflammasomes to produce immune response, leading to antitumor immunity and cure.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Neurosciences

Repolarization of glioblastoma macrophage cells using non-agonistic Dectin-1 ligand encapsulating TLR-9 agonist: plausible role in regenerative medicine against brain tumor

Rohit Kumar Tiwari et al.

Summary: This study investigates the potential of nano-encapsulated CpG ODN as a critical factor in repolarizing M2 macrophages to the desired pro-inflammatory type, showing promising results in inducing apoptosis in glioblastoma cells and suggesting the suitability of CpG ODN carrying nanoformulations as emerging therapeutic intervention for GBM.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2021)

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Review Clinical Neurology

New strategies for managing adult gliomas

Alastair J. Kirby et al.

Summary: Gliomas are challenging to treat and have shown little improvement in prognosis over the past few decades. New therapeutic strategies are needed to address treatment resistance, malignant progression, and tumor recurrence. Recent advancements in understanding the biology of adult gliomas are informing novel approaches to treatment.

JOURNAL OF NEUROLOGY (2021)

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Article Oncology

Microglia/macrophages express alternative proangiogenic factors depending on granulocyte content in human glioblastoma

Anne Blank et al.

Summary: The study identified two distinct myeloid cell populations in human glioblastoma, which play a role in tumor escape mechanisms by expressing alternative proangiogenic factors. Limited efficacy of anti-angiogenic therapy may be due to tumor-infiltrating myeloid cells bypassing VEGF-mediated pathways through expression of alternative proangiogenic factors.

JOURNAL OF PATHOLOGY (2021)

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Article Clinical Neurology

Tumor cell and immune cell profiles in primary human glioblastoma: Impact on patient outcome

Maria Gonzalez-Tablas Pimenta et al.

Summary: This study investigated the cellular composition of 55 GBM samples and correlated the tumor immune profile with patient features and outcomes. The GBM samples primarily consisted of tumor and normal astrocytic cells, along with a significant but variable fraction of immune cells. Three distinct immune profiles were identified in the GBM samples, with untreated patients showing worse outcomes when immune infiltrates included a mixed population of myeloid and T-lymphoid cells.

BRAIN PATHOLOGY (2021)

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Review Neurosciences

Understanding the glioblastoma tumor biology to optimize photodynamic therapy: From molecular to cellular events

Luis Exequiel Ibarra et al.

Summary: PDT is a therapeutic approach that involves the destruction of tumor cells by reactive oxygen species induced by light after prior treatment with a photosensitizing agent. Recent advances have expanded its experimental application to other effects that could enhance overall performance against GBM.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

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Review Pharmacology & Pharmacy

Potential of IDH mutations as immunotherapeutic targets in gliomas: a review and meta-analysis

Nazareno Gonzalez et al.

Summary: The presence of mutated IDH correlates with better prognosis in gliomas, but its role in antitumor immunity and response to immunotherapy is not fully understood. Understanding the relationship between genetic features and the tumor immune microenvironment may help develop appropriate therapeutic strategies. The tumor immune microenvironment differs not only based on IDH mutation status, but also within glioma subtypes, suggesting that specific therapeutic combinations may be beneficial for different subsets of glioma patients.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

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Article Biochemistry & Molecular Biology

BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells

Xin Zhang et al.

Summary: BATF2 has been shown to inhibit the growth of glioma and the recruitment of myeloid-derived suppressor cells. Extracellular vesicles from BATF2-overexpressing cells were found to inhibit MDSCs chemotaxis, and the abundance of BATF2-positive EVs in plasma can distinguish different stages of glioma. This study provides insights into the regulatory functions of BATF2 and its potential prognostic value in glioma.

ONCOGENE (2021)

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Review Cell Biology

Myeloid Cells in Glioblastoma Microenvironment

Alessandra De Leo et al.

Summary: Glioblastoma (GBM) is a highly aggressive and malignant brain tumor with a unique immune microenvironment that is resistant to immunotherapy. Myeloid cells play a crucial role in regulating immune and therapeutic responses in GBM. Studying the characteristics and functions of different populations of myeloid cells in GBM offers new insights for targeting specific cells for therapeutic purposes.

CELLS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Editorial Material Biochemistry & Molecular Biology

From macrophage biology to macrophage-based cellular immunotherapies

Elvira Mass et al.

GENE THERAPY (2021)

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Editorial Material Biotechnology & Applied Microbiology

Cellular Trojan horses for delivery of nanomedicines to brain tumors: where do we stand and what is next?

Luis Exequiel Ibarra

NANOMEDICINE (2021)

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Article Multidisciplinary Sciences

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

Erik Jung et al.

Summary: The perivascular niche (PVN) and tumor microtubes (TMs) in glioblastoma have been found to play a role in tumor progression and resistance to therapies, with the potential for partial compensation between the two niches. Glioma cells in both the PVN and network integration environments show resistance to radio- and chemotherapy.

NATURE COMMUNICATIONS (2021)

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Review Immunology

The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)

Cristina Barca et al.

Summary: Immunomodulatory therapies targeting microglial cells have shown promise in neurological conditions, but the complexity of the inflammatory response may limit their efficacy and lead to therapy resistance. Inhibition of CSF-1R holds potential therapeutic value in diseases, with ongoing research and developments exploring new possibilities for its application in treating glioma and stroke.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Interstitial Photodynamic Therapy for Glioblastomas: A Standardized Procedure for Clinical Use

Henri-Arthur Leroy et al.

Summary: Glioblastomas (GBMs) are aggressive brain tumors with poor prognosis. The standard treatment includes surgery, radiotherapy, and chemotherapy, but survival is limited, particularly for non-surgical patients. Interstitial photodynamic therapy (iPDT) shows promise for improving local control of GBM, with a standardized workflow proposed for clinical application. The procedure involves intraoperative imaging, treatment planning, and robotic assistance for optical fiber implantation.

CANCERS (2021)

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Review Medicine, General & Internal

Checkpoint Inhibitors as High-Grade Gliomas Treatment: State of the Art and Future Perspectives

Pasquale Persico et al.

Summary: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults, with no effective treatment currently available. While immune checkpoint inhibitors (ICI) have shown success in other malignancies, they have not yet made an impact in neuro-oncology. This review summarizes the status of ICI investigation in high-grade gliomas and explores new approaches and potential biomarkers.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Oncology

The Role of Macrophages in Cancer Development and Therapy

Ewa Cendrowicz et al.

Summary: Tumor-Associated Macrophages (TAMs) play a crucial role in tumor development and are potential targets for cancer therapy due to their influence on immunity and tumor microenvironment.

CANCERS (2021)

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Article Oncology

Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma

Justyna M. Przystal et al.

Summary: This study investigated treatment strategies that target tumor-associated macrophages in the microenvironment by blocking CSF1R, alone or in combination with PD1 blockade. The results suggest that targeting CSF1R is a promising therapeutic approach for glioblastoma, potentially in conjunction with PD1 inhibition, as shown by increased survival in mouse models and enhanced attack of the immune system in ex vivo microtumor models.

CANCERS (2021)

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Article Oncology

Brain and other central nervous system tumor statistics, 2021

Kimberly D. Miller et al.

Summary: Brain and other CNS tumors are highly fatal cancers in the United States, with different incidence rates and survival rates among different races and age groups. Survival disparities, especially in childhood tumors, highlight the importance of providing more resources to advance research and understand the reasons behind differences in brain tumor occurrence, especially among rarer subtypes and understudied populations.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Oncology

Noncoding RNAs involved in the STAT3 pathway in glioma

Zheng Bian et al.

Summary: Glioma, the most common malignant primary brain tumor in adults with poor prognosis, lacks proper clinical therapeutic targets. STAT3, involved in various processes in glioma, is considered as an ideal therapeutic target. Noncoding RNAs can regulate the ectopic expression of STAT3 in glioma.

CANCER CELL INTERNATIONAL (2021)

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Editorial Material Immunology

Chimeric antigen receptor macrophage for glioblastoma immunotherapy: the way forward

Lidia Gatto et al.

IMMUNOTHERAPY (2021)

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Review Medicine, Research & Experimental

Macrophages as a weapon in anticancer cellular immunotherapy

Dmitry Aminin et al.

Summary: Anticancer immunotherapy is a treatment that activates the immune system to fight tumors with high specificity and low side effects. Macrophages show promising potential in cancer therapy, with M1 macrophages being a potential effective weapon in anticancer cellular immunotherapy.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Fan Yang et al.

Summary: This study demonstrates that IL-6 blockade, in combination with a CD40 agonist, overcomes macrophage-mediated immunosuppression and sensitizes glioblastoma to immune checkpoint blockade in preclinical models, providing promising opportunities for GBM and other solid tumors.

NATURE COMMUNICATIONS (2021)

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Review Oncology

Tumor-Associated Microglia and Macrophages in the Glioblastoma Microenvironment and Their Implications for Therapy

Rikke Sick Andersen et al.

Summary: Glioblastoma, the most common and malignant primary brain tumor, has a poor prognosis with limited treatment options. Targeting tumor-associated microglia and macrophages (TAMs) in addition to cancer cells may be a promising therapeutic strategy. Understanding the interactions between TAMs and cancer cells is crucial for developing effective treatment approaches.

CANCERS (2021)

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Article Pharmacology & Pharmacy

Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors

Nuria Arias-Ramos et al.

Summary: Conjugated polymer nanoparticles (CPNs) have shown excellent properties such as high fluorescence brightness, high absorption coefficients, and good stability in water and physiological medium, making them suitable for biomedical applications. In this study, CPNs were modified by incorporating metal oxide magnetic cores, allowing in vivo monitoring using MRI and intravital fluorescence. The biocompatible IONP-doped CPNs showed good performance in tumor cells and organs, with no adverse effects on photodynamic therapy (PDT) cytotoxicity.

PHARMACEUTICS (2021)

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Review Cell Biology

Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor-Glioma Therapy?

Ni Tong et al.

Summary: TAMs play a crucial role in the progression of glioma, and treatment strategies targeting TAMs include inhibiting recruitment, reducing viability, and altering phenotype. Research progress has shown the potential effectiveness of anti-tumor therapy targeting TAMs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Green & Sustainable Science & Technology

Macrophage-mediated cancer drug delivery

H. -F. Wang et al.

Summary: Cell-mediated drug delivery systems using macrophages as carriers have shown promising potential for cancer therapy, due to their excellent biocompatibility and ability to target tumor microenvironment. Research on tumor-associated macrophages (TAMs) and nanoparticle-loaded macrophages as drug carriers provides valuable insights for novel cancer treatment strategies.

MATERIALS TODAY SUSTAINABILITY (2021)

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Review Oncology

Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma

Ruth M. Urbantat et al.

Summary: Chemokine signaling plays a crucial role in glioblastoma, potentially serving as therapeutic targets for new treatment regimens. Further research and clinical studies are needed to explore the efficacy of these novel chemokine-targeting therapies.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-kappa B pathways

Mingyu Qian et al.

ONCOGENE (2020)

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Article Oncology

TMZ regulates GBM stemness via MMP14-DLL4-Notch3 pathway

Ilya Ulasov et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Oncology

CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2

Caren Yu-Ju Wu et al.

NEURO-ONCOLOGY (2020)

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Review Instruments & Instrumentation

Delivery across the blood-brain barrier: nanomedicine for glioblastoma multiforme

Lynn Jena et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma

Yolanda Pires-Afonso et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

Aaron J. Sorrin et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2020)

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Review Oncology

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Sue Han et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Oncology

Tumor-associated macrophage interleukin-β promotes glycerol-3-phosphate dehydrogenase activation, glycolysis and tumorigenesis in glioma cells

Jian Lu et al.

CANCER SCIENCE (2020)

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Review Biochemistry & Molecular Biology

Tumor Cell Invasion in Glioblastoma

Arabel Vollmann-Zwerenz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Chemistry, Multidisciplinary

Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment

Belen Delgado-Martin et al.

ADVANCED SCIENCE (2020)

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Article Oncology

Role of CX3CR1 signaling in malignant transformation of gliomas

Sungho Lee et al.

NEURO-ONCOLOGY (2020)

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Review Oncology

Management of glioblastoma: State of the art and future directions

Aaron C. Tan et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Review Cell Biology

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Joanna L. Birch et al.

CELLULAR SIGNALLING (2020)

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Review Oncology

Cellular Plasticity and Tumor Microenvironment in Gliomas: The Struggle to Hit a Moving Target

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CANCERS (2020)

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Review Biochemistry & Molecular Biology

Current Perspectives on Therapies, Including Drug Delivery Systems, for Managing Glioblastoma Multiforme

Mahendran Bhaskaran et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

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ADVANCED MATERIALS (2020)

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Trojan horse monocyte-mediated delivery of conjugated polymer nanoparticles for improved photodynamic therapy of glioblastoma

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NANOMEDICINE (2020)

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Editorial Material Biochemical Research Methods

Macrophages enter CAR immunotherapy

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NATURE METHODS (2020)

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Progress in Clinical Trials of Photodynamic Therapy for Solid Tumors and the Role of Nanomedicine

Hashem O. Alsaab et al.

CANCERS (2020)

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Tumor Treating Fields (TTFields) Hinder Cancer Cell Motility through Regulation of Microtubule and Actin Dynamics

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CANCERS (2020)

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Current Opinion on Molecular Characterization for GBM Classification in Guiding Clinical Diagnosis, Prognosis, and Therapy

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FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy

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COMMUNICATIONS BIOLOGY (2020)

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Article Oncology

Human macrophages engineered to secrete a bispecific T cell engager support antigen-dependent T cell responses to glioblastoma

Jennifer L. Gardell et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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The association between incidence and mortality of brain cancer and human development index (HDI): an ecological study

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BMC PUBLIC HEALTH (2020)

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Photodynamic therapy of Glioblastoma cells using doped conjugated polymer nanoparticles: An in vitro comparative study based on redox status

Matias Daniel Caverzan et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2020)

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A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis

Xumei Ouyang et al.

BIOMATERIALS SCIENCE (2020)

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Review Neurosciences

Astrocytes, the rising stars of the glioblastoma microenvironment

Mayra Brandao et al.

GLIA (2019)

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Article Oncology

The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion

Laura Pinton et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Oncology

Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12

Frank A. Giordano et al.

CANCERS (2019)

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Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival

Marko Gjorgjevski et al.

BIOSCIENCE REPORTS (2019)

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The TICking clock of EGFR therapy resistance in glioblastoma: Target Independence or target Compensation

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DRUG RESISTANCE UPDATES (2019)

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Differential microglia and macrophage profiles in human IDH-mutant and -wild type glioblastoma

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Oncotarget (2019)

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Review Oncology

Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue

Alessio D'Alessio et al.

CANCERS (2019)

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A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma

Patrick Y. Wen et al.

CLINICAL CANCER RESEARCH (2019)

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Article Clinical Neurology

Tumor-associated macrophage related interleukin-6 in cerebrospinal fluid as a prognostic marker for glioblastoma

Tatsuo Hori et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2019)

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Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages

Zhihong Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Regulatory Framework for Advanced Therapy Medicinal Products in Europe and United States

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FRONTIERS IN PHARMACOLOGY (2019)

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Predominance of M2 macrophages in gliomas leads to the suppression of local and systemic immunity

Aurobind Vidyarthi et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Review Cell Biology

Pivotal Role of STAT3 in Shaping Glioblastoma Immune Microenvironment

Christina Piperi et al.

CELLS (2019)

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Review Oncology

5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas

K. Mahmoudi et al.

JOURNAL OF NEURO-ONCOLOGY (2019)

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Review Oncology

Glioblastoma: Microenvironment and Niche Concept

Davide Schiffer et al.

CANCERS (2019)

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Review Pharmacology & Pharmacy

Macrophages as delivery vehicles for anticancer agents

Steen J. Madsen et al.

THERAPEUTIC DELIVERY (2019)

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Highlighted STAT3 as a potential drug target for cancer therapy

Haeri Lee et al.

BMB REPORTS (2019)

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Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

Xin Cui et al.

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Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors

David M. Hyman et al.

CLINICAL CANCER RESEARCH (2018)

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A Spatio-Temporal Model of Macrophage-Mediated Drug Resistance in Glioma Immunotherapy

Yongjiang Zheng et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Liposomal TriCurin, A Synergistic Combination of Curcumin, Epicatechin Gallate and Resveratrol, Repolarizes Tumor-Associated Microglia/Macrophages, and Eliminates Glioblastoma (GBM) and GBM Stem Cells

Sumit Mukherjee et al.

MOLECULES (2018)

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Review Clinical Neurology

Glioblastoma niches: from the concept to the phenotypical reality

Davide Schiffer et al.

NEUROLOGICAL SCIENCES (2018)

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Review Biochemistry & Molecular Biology

An Experimenter's Guide to Glioblastoma Invasion Pathways

Mark C. de Gooijer et al.

TRENDS IN MOLECULAR MEDICINE (2018)

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Primary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy

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DRUG DELIVERY (2018)

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Distinct Phenotypic Clusters of Glioblastoma Growth and Response Kinetics Predict Survival

Corbin A. Rayfield et al.

JCO CLINICAL CANCER INFORMATICS (2018)

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PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models

Fan Lin et al.

CLINICAL CANCER RESEARCH (2017)

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Review Chemistry, Multidisciplinary

Exploiting the cancer niche: Tumor-associated macrophages and hypoxia as promising synergistic targets for nano-based therapy

Vera L. Silva et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Review Biochemistry & Molecular Biology

CCL2/CCR2 signaling pathway in glioblastoma multiforme

Alireza Vakilian et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

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Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas

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ONCOGENE (2017)

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Review Oncology

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

Xiang Zheng et al.

ONCOTARGET (2017)

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The Anti-Tumor Effects of M1 Macrophage-Loaded Poly (ethylene glycol) and Gelatin-Based Hydrogels on Hepatocellular Carcinoma

Alberto Daniel Guerra et al.

THERANOSTICS (2017)

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Phenotype, function, and differentiation potential of human monocyte subsets

Lisa B. Boyette et al.

PLOS ONE (2017)

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Multifaceted C-X-C Chemokine Receptor 4 (CXCR4) Inhibition Interferes with Anti-Vascular Endothelial Growth Factor Therapy-Induced Glioma Dissemination

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AMERICAN JOURNAL OF PATHOLOGY (2017)

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Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma

Zhihong Chen et al.

CANCER RESEARCH (2017)

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Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

Alexander Scholz et al.

EMBO MOLECULAR MEDICINE (2016)

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Review Clinical Neurology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

ACTA NEUROPATHOLOGICA (2016)

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Efficient production and enhanced tumor delivery of engineered extracellular vesicles

Dionysios C. Watson et al.

BIOMATERIALS (2016)

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Article Oncology

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

Alan L. Chang et al.

CANCER RESEARCH (2016)

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Macrophage-based cell therapies: The long and winding road

Simon Lee et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Neurosciences

The role of microglia and macrophages in glioma maintenance and progression

Dolores Hambardzumyan et al.

NATURE NEUROSCIENCE (2016)

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Article Oncology

Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models

Takuhiro Shoji et al.

NEURO-ONCOLOGY (2016)

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Review Clinical Neurology

Photodynamic Therapy for Malignant Brain Tumors

Jiro Akimoto

NEUROLOGIA MEDICO-CHIRURGICA (2016)

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Article Oncology

Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

Xiaofan Guo et al.

ONCOTARGET (2016)

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Article Engineering, Biomedical

Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

Wen-Chia Huang et al.

BIOMATERIALS (2015)

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Review Cell Biology

Cancer stem cells in glioblastoma

Justin D. Lathia et al.

GENES & DEVELOPMENT (2015)

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Article Cell Biology

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

Wenchao Zhou et al.

NATURE CELL BIOLOGY (2015)

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Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

Xi Feng et al.

ONCOTARGET (2015)

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Article Oncology

Macrophage Ablation Reduces M2-Like Populations and Jeopardizes Tumor Growth in a MAFIA-Based Glioma Model

Konrad Gabrusiewicz et al.

NEOPLASIA (2015)

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Review Oncology

Glioblastoma: Defining Tumor Niches

Dolores Hambardzumyan et al.

TRENDS IN CANCER (2015)

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Review Oncology

OPINION Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma

Frank B. Furnari et al.

NATURE REVIEWS CANCER (2015)

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Article Oncology

Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells

Akemi Kosaka et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)

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Review Oncology

Temozolomide and Radiotherapy for Newly Diagnosed Glioblastoma Multiforme: A Systematic Review

Li-Juan Yang et al.

CANCER INVESTIGATION (2014)

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Review Neurosciences

The role of CXCR4 in highly malignant human gliomas biology: Current knowledge and future directions

Filippo Gagliardi et al.

GLIA (2014)

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Article Medicine, Research & Experimental

Propofol exerts anti-hepatocellular carcinoma by microvesicle-mediated transfer of miR-142-3p from macrophage to cancer cells

Jian Zhang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

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Article Multidisciplinary Sciences

Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells

Stacey Watkins et al.

NATURE COMMUNICATIONS (2014)

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Article Oncology

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

Chakrapani Tripathi et al.

ONCOTARGET (2014)

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Macrophage as cellular vehicles for delivery of nanoparticles

Song Feng et al.

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES (2014)

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Review Biochemistry & Molecular Biology

Recruitment of monocytes/macrophages in different tumor microenvironments

Heon-Woo Lee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2013)

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Review Endocrinology & Metabolism

Immunologic privilege in the central nervous system and the blood-brain barrier

Leslie L. Muldoon et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

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Article Biochemistry & Molecular Biology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck et al.

NATURE MEDICINE (2013)

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Review Biochemistry & Molecular Biology

Review: Molecular mechanism of microglia stimulated glioblastoma invasion

Salvatore J. Coniglio et al.

MATRIX BIOLOGY (2013)

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Review Oncology

Understanding the role of cytokines in Glioblastoma Multiforme pathogenesis

Vivian F. Zhu et al.

CANCER LETTERS (2012)

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Review Clinical Neurology

A novel treatment for glioblastoma: integrin inhibition

Marc C. Chamberlain et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2012)

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Article Medicine, Research & Experimental

Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model

Shu-Chi Wang et al.

LABORATORY INVESTIGATION (2012)

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Article Oncology

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

Yuji Piao et al.

NEURO-ONCOLOGY (2012)

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Article Cell Biology

\Generation of Mature Murine Monocytes from Heterogeneous Bone Marrow and Description of Their Properties

Alexander Francke et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2011)

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Review Immunology

Microglial cell origin and phenotypes in health and disease

Kaoru Saijo et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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Article Oncology

Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9

Sasa Kenig et al.

CANCER LETTERS (2010)

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Article Oncology

Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1

Marco Erreni et al.

EUROPEAN JOURNAL OF CANCER (2010)

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Article Oncology

CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs)

Janka Held-Feindt et al.

EXPERIMENTAL CELL RESEARCH (2010)

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Article Clinical Neurology

Development of the WHO Classification of Tumors of the Central Nervous System: A Historical Perspective

Bernd W. Scheithauer

BRAIN PATHOLOGY (2009)

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Article Neurosciences

Stat3 Inhibition Activates Tumor Macrophages and Abrogates Glioma Growth in Mice

Leying Zhang et al.

GLIA (2009)

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Article Engineering, Biomedical

ALA and Photofrin® fluorescence-guided resection and repetitive PDT in glioblastoma multiforme:: a single centre Phase III randomised controlled trial

M. Sam Eljamel et al.

LASERS IN MEDICAL SCIENCE (2008)

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Article Medicine, Research & Experimental

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

Chia-Lin Tsou et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Article Oncology

A perivascular niche for brain tumor stem cells

Christopher Calabrese et al.

CANCER CELL (2007)

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Article Medicine, Research & Experimental

Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion

David Zagzag et al.

LABORATORY INVESTIGATION (2006)

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Article Biochemistry & Molecular Biology

Activation of chemokine receptor CXCR4 in malignant glioma cells promotes the production of vascular endothelial growth factor

SX Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Review Biochemistry & Molecular Biology

Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion

AC Bellail et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)

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Article Oncology

CXCL12 in malignant glial tumors: a possible role in angiogenesis and cross-talk between endothelial and tumoral cells

A Salmaggi et al.

JOURNAL OF NEURO-ONCOLOGY (2004)

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