Influence of Tiapride and Topiramate on Tic Severity and Behavioral/Emotional Problems in Children with Tourette Syndrome: A Retrospective Study

Objectives: To investigate the effect of tiapride and topiramate on patients with Tourette syndrome (TS). Methods: This retrospective analysis included 126 children diagnosed with TS at Children's Hospital of Chongqing Medical University from 2019 to 2021, with treatment including tiapride (n = 60) and topiramate (n = 66). Their tic severity values were assessed with the Yale Global Tic Severity Scale (YGTSS). Furthermore, behavioral and emotional problems were assessed with the Conner's Parent Rating Scale (CPRS) and the Children Behavior Checklist (CBCL). Results: Compared with premedication, the scores of tic severity were significantly decreased in both tiapride and topiramate groups after treatment, especially topiramate. Moreover, it was noted that five subscores of CPRS were significantly reduced in TS patients thanks to medication. However, there was no significant difference in CBCL after treatment, in both tiapride and topiramate groups. Conclusions: Tiapride and topiramate were proven to be effective on tics and some behavioral/emotional problems in TS patients, and topiramate may provide better treatment.

Automated summary

This retrospective study analyzed 126 children diagnosed with Tourette syndrome (TS) at Children's Hospital of Chongqing Medical University from 2019 to 2021. The treatment included tiapride (n = 60) and topiramate (n = 66). The results showed that both tiapride and topiramate significantly reduced tic severity scores, with topiramate showing better results. Furthermore, medication led to significant reduction in five subscores of CPRS in TS patients. However, there was no significant difference in CBCL scores after treatment in both tiapride and topiramate groups.