Treatment of Oligometastatic Non-Small Cell Lung Cancer: An ASTRO/ESTRO Clinical Practice Guideline

Article Oncology

Randomized Trial of First-Line Tyrosine Kinase Inhibitor With or Without Radiotherapy for Synchronous Oligometastatic EGFR-Mutated Non-Small Cell Lung Cancer

Xiao-Shan Wang et al.

Summary: Adding upfront local therapy using RT significantly improves PFS and OS for EGFR-mutated NSCLC compared to the use of a first-line TKI alone.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2023)

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Article Oncology

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline

Michael A. Vogelbaum et al.

Summary: The purpose of this study is to provide guidelines for clinicians on treating patients with brain metastases from solid tumors. The study conducted a systematic review of the literature and found that surgery is a reasonable option for patients with brain metastases. Local therapy should be given to patients with symptomatic brain metastases, regardless of the systemic therapy used. For patients with asymptomatic brain metastases, local therapy should not be deferred unless specifically recommended. Several regimens were recommended for different types of cancer. For patients with no systemic therapy options, stereotactic radiosurgery (SRS) alone should be offered. Memantine and hippocampal avoidance should be considered for patients receiving whole brain radiation therapy. Patients with low Karnofsky Performance Status and no systemic therapy options do not benefit from radiation therapy.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Medicine, General & Internal

Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial

Hisashi Saji et al.

LANCET (2022)

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Article Oncology

Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline

Vinai Gondi et al.

Summary: This article presents the latest guidelines for the management of brain metastases, including advanced radiation therapy techniques and systemic therapies with central nervous system activity. The guidelines are based on a systematic review and provide recommendations using a predefined consensus-building methodology and grading system. Strong recommendations are made for the use of stereotactic radiosurgery (SRS) and upfront local therapy, with conditional recommendations for surgical resection and safe deferral of local therapy. Additional recommendations are made for patients with limited metastases and favorable prognosis.

PRACTICAL RADIATION ONCOLOGY (2022)

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Article Oncology

Imaging-Based Prevalence of Oligometastatic Disease: A Single-Center Cross-Sectional Study

Sebastian M. Christ et al.

Summary: This study examined the prevalence of oligometastasis using oncological imaging and found that approximately half of metastatic cancer patients have a limited tumor burden detectable on PET and cMRI imaging.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Article Oncology

Planning Trade-offs for SABR in Patients With 4 to 10 Metastases: A Substudy of the SABRCOMET-10 Randomized Trial

Samaher Ashram et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Article Oncology

NRG-BR002: A phase IIR/III trial of standard of care systemic therapy with or without stereotactic body radiotherapy (SBRT) and/or surgical resection (SR) for newly oligometastatic breast cancer (NCT02364557).

Steven J. Chmura et al.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Oncology

The oligometastatic spectrum in the era of improved detection and modern systemic therapy

Rohan R. Katipally et al.

Summary: This review reframes the oligometastatic phenotype as a dynamic state that can be improved with locally ablative, metastasis-directed therapy. The authors highlight important risk factors defining the metastatic spectrum and provide strategies for integrating local therapies with modern systemic treatments.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Oncology

Prospective trial of immuno(chemo)therapy before resection, definitive chemoradiotherapy or palliative therapy in patients with locally advanced or oligometastatic non-small cell lung cancer without a primary curative option

Martin Faehling et al.

Summary: The study showed that induction immuno(chemo)therapy in locally advanced or oligometastatic NSCLC patients without primary curative options resulted in a high rate of curative treatment. Patients who underwent resection achieved a high rate of prognostically favorable pathological response.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Oncology

Stereotactic or conformal radiotherapy for adrenal metastases: Patient characteristics and outcomes in a multicenter analysis

Daniel Buergy et al.

Summary: Results from a retrospective multicenter study within the DEGRO framework showed that patients with adrenal metastases treated with different types of radiotherapy had higher freedom from local progression in the SBRT group compared to the Pall-RT group, and longer overall survival in the SBRT group as well.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Oncology

Consolidative stereotactic ablative radiotherapy (SABR) to intrapulmonary lesions is associated with prolonged progression-free survival and overall survival in oligometastatic NSCLC patients: A prospective phase 2 study

Monika Blake-Cerda et al.

Summary: The study evaluated SABR as a local consolidative therapy in oligometastatic NSCLC patients, showing favorable outcomes in terms of PFS and OS.

LUNG CANCER (2021)

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Review Health Care Sciences & Services

Oligometastatic non-small cell lung cancer: a narrative review of stereotactic ablative radiotherapy

Michael Dohopolski et al.

Summary: Non-small cell lung cancer is the most common and deadly malignancy in the U.S., with the majority of patients progressing to metastatic disease. However, patients with oligometastatic disease may potentially be cured using aggressive local therapies like SAbR in combination with systemic treatment. SAbR has been shown to effectively treat oligometastatic NSCLC, particularly when combined with immunotherapy, offering a potentially tolerable and effective treatment option for these patients.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Oncology

A risk stratification scheme for synchronous oligometastatic non-small cell lung cancer developed by a multicentre analysis

Lorenzo Spaggiari et al.

Summary: This study analyzed the long-term outcomes of synchronous oligometastatic NSCLC patients treated with curative intent, identifying age <= 65 years, single metastasis, and contralateral lung metastases as factors associated with better prognosis, while pathological N2 metastases were negatively correlated with survival. A simple risk classification scheme was established based on these prognostic factors.

LUNG CANCER (2021)

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Article Oncology

EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

E. Le Rhun et al.

ANNALS OF ONCOLOGY (2021)

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Article Oncology

Radiation Toxicity in Patients With Collagen Vascular Disease: A Meta-Analysis of Case-Control Studies

Parvez M. Shaikh et al.

Summary: The meta-analysis investigated the risk of radiation toxicity for patients with collagen vascular disease (CVD) compared with controls. The results indicated that patients with CVD had significantly higher rates of acute and late toxicities, especially for certain CVD subtypes and treatment sites.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Oncology

An international pooled analysis of SBRT outcomes to oligometastatic spine and non-spine bone metastases

Yilin Cao et al.

Summary: This study reviewed oligometastatic patients treated with SBRT for spine and non-spine bone lesions at six international institutions, finding no significant difference in local recurrence, widespread progression, and overall survival between the two groups. Dose escalation for large and/or radioresistant non-spine bone lesions should be considered.

RADIOTHERAPY AND ONCOLOGY (2021)

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Article Oncology

Imaging and its Impact on Defining the Oligometastatic State

Ali Pirasteh et al.

Summary: Successful treatment of oligometastatic disease relies on timely detection and localization, with imaging playing a crucial role. Challenges in managing OMD are reflected in imaging, despite technological advances. This review highlights the role of imaging in detecting and evaluating OMD in various organ systems, aiming to provide practical guidance for clinicians.

SEMINARS IN RADIATION ONCOLOGY (2021)

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Review Oncology

Clinical prognostic factors in surgically treated oligometastatic non-small cell lung cancer: a systematic review

Luca Bertolaccini et al.

Summary: This systematic review investigated clinical prognostic factors in OM-NSCLC patients treated with radical intent. Positive prognostic factors for survival included smoking cessation, age <60, histologic grade G1/G2, and pN0, while the presence of extra-brain OM and multiple metastases negatively affected survival. Aggressive treatment should be considered for stable OM-NSCLC patients with single organ site extrathoracic M1 disease and no intrathoracic lymph node involvement, even in the absence of randomized evidence.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

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Article Oncology

Definitive Local Therapy for Oligo-recurrence in Patients With Completely Resected Non-small Cell Lung Cancer

Haruhisa Matsuguma et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2020)

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Review Oncology

A Primer on Interstitial Lung Disease and Thoracic Radiation

Christopher D. Goodman et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

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Review Oncology

Characterisation and classification of oligometastatic disease: a European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus recommendation

Matthias Guckenberger et al.

LANCET ONCOLOGY (2020)

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Review Oncology

Stereotactic Ablative Radiotherapy for the Management of Spinal Metastases A Review

Rachel M. Glicksman et al.

JAMA ONCOLOGY (2020)

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Article Oncology

Stereotactic Ablative Radiotherapy for the Comprehensive Treatment of Oligometastatic Cancers: Long-Term Results of the SABR-COMET Phase II Randomized Trial

David A. Palma et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document

Yolande Lievens et al.

RADIOTHERAPY AND ONCOLOGY (2020)

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Review Oncology

European Cancer Organisation Essential Requirements for Quality Cancer Care (ERQCC): Lung cancer

Thierry Berghmans et al.

LUNG CANCER (2020)

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Article Oncology

Factors related to primary cancer death and non-primary cancer death in patients treated with stereotactic body radiotherapy for pulmonary oligometastases

Takaya Yamamoto et al.

CANCER MEDICINE (2020)

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Article Oncology

Stereotactic ablative body radiotherapy in patients with oligometastatic cancers: a prospective, registry-based, single-arm, observational, evaluation study

Anastasia Chalkidou et al.

LANCET ONCOLOGY (2020)

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Article Oncology

Efficacy of Local Consolidative Therapy for Oligometastatic Lung Adenocarcinoma Patients Harboring Epidermal Growth Factor Receptor Mutations

Fang Hu et al.

CLINICAL LUNG CANCER (2019)

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Article Oncology

M1b Disease in the 8th Edition of TNM Staging of Lung Cancer: Pattern of Single Extrathoracic Metastasis and Clinical Outcome

Hyesun Park et al.

ONCOLOGIST (2019)

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Article Oncology

Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non-Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study

Daniel R. Gomez et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Oncology

Radical consolidative treatment provides a clinical benefit and long-term survival in patients with synchronous oligometastatic non-small cell lung cancer: A phase II study

Oscar Arrieta et al.

LUNG CANCER (2019)

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Article Oncology

Long-term Follow-up and Patterns of Recurrence of Patients With Oligometastatic NSCLC Treated With Pulmonary SBRT

Juliane Hoerner-Rieber et al.

CLINICAL LUNG CANCER (2019)

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Article Oncology

Pembrolizumab After Completion of Locally Ablative Therapy for Oligometastatic Non-Small Cell Lung Cancer: A Phase 2 Trial

Joshua M. Bauml et al.

JAMA ONCOLOGY (2019)

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Article Oncology

Definition of Synchronous Oligometastatic Non-Small Cell Lung Cancer-A Consensus Report

Anne-Marie C. Dingemans et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

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Review Clinical Neurology

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Treatment Options for Adults With Multiple Metastatic Brain Tumors

Mario Ammirati et al.

NEUROSURGERY (2019)

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Review Clinical Neurology

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Whole Brain Radiation Therapy in Adults With Newly Diagnosed Metastatic Brain Tumors

Laurie E. Gaspar et al.

NEUROSURGERY (2019)

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Article Respiratory System

Analysis of key clinical features for achieving complete remission in stage III and IV non-small cell lung cancer patients

Takuya Aoki et al.

RESPIRATORY RESEARCH (2019)

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Review Clinical Neurology

Stereotactic Radiosurgery in the Management of Limited (1-4) Brain Metasteses: Systematic Review and International Stereotactic Radiosurgery Society Practice Guideline

Samuel T. Chao et al.

NEUROSURGERY (2018)

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Review Oncology

Strategies and technical challenges for imaging oligometastatic disease: Recommendations from the European Organisation for Research and Treatment of Cancer imaging group

Nandita M. deSouza et al.

EUROPEAN JOURNAL OF CANCER (2018)

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Article Oncology

Long-Term Outcomes of a Phase 2 Trial of Chemotherapy With Consolidative Radiation Therapy for Oligometastatic Non-Small Cell Lung Cancer

W. Jeffrey Petty et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

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Article Multidisciplinary Sciences

Classification for long-term survival in oligometastatic patients treated with ablative radiotherapy: A multi-institutional pooled analysis

Julian C. Hong et al.

PLOS ONE (2018)

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Article Respiratory System

Prognostic factors of oligometastatic non-small cell lung cancer: a meta-analysis

Shangbiao Li et al.

JOURNAL OF THORACIC DISEASE (2018)

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Article Oncology

Consolidative Radiotherapy for Limited Metastatic Non-Small-Cell Lung Cancer A Phase 2 Randomized Clinical Trial

Puneeth Iyengar et al.

JAMA ONCOLOGY (2018)

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Article Oncology

Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

D. Planchard et al.

ANNALS OF ONCOLOGY (2018)

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Article Oncology

Progression-Free Survival and Overall Survival Beyond 5 Years of NSCLC Patients With Synchronous Oligometastases Treated in a Prospective Phase II Trial (NCT 01282450)

Dirk De Ruysscher et al.

JOURNAL OF THORACIC ONCOLOGY (2018)

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Review Oncology

Addition of radiotherapy to the primary tumour in oligometastatic NSCLC: A systematic review and meta-analysis

Fausto Petrelli et al.

LUNG CANCER (2018)

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Review Oncology

An integrated multidisciplinary algorithm for the management of spinal metastases: an International Spine Oncology Consortium report

Daniel E. Spratt et al.

LANCET ONCOLOGY (2017)

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Article Oncology

ESTRO ACROP consensus guideline on implementation and practice of stereotactic body radiotherapy for peripherally located early stage non-small cell lung cancer

Matthias Guckenberger et al.

RADIOTHERAPY AND ONCOLOGY (2017)

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Article Respiratory System

Should aggressive thoracic therapy be performed in patients with synchronous oligometastatic non-small cell lung cancer? A meta-analysis

Dianhe Li et al.

JOURNAL OF THORACIC DISEASE (2017)

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Article Oncology

Definitive Stereotactic Body Radiotherapy (SBRT) for Extracranial Oligometastases: An International Survey of >1000 Radiation Oncologists

Stephen L. Lewis et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2017)

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Review Clinical Neurology

Spine Stereotactic Body Radiotherapy: Indications, Outcomes, and Points of Caution

Chia-Lin Tseng et al.

GLOBAL SPINE JOURNAL (2017)

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Review Oncology

Toxicity of concurrent stereotactic radiotherapy and targeted therapy or immunotherapy: A systematic review

Stephanie G. C. Kroeze et al.

CANCER TREATMENT REVIEWS (2017)

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Article Oncology

Might radiation therapy in addition to chemotherapy improve overall survival of patients with non-oligometastatic Stage IV non-small cell lung cancer?: Secondary analysis of two prospective studies

ShengFa Su et al.

BMC CANCER (2016)

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Article Oncology

Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: a multicentre, randomised, controlled, phase 2 study

Daniel R. Gomez et al.

LANCET ONCOLOGY (2016)

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Article Oncology

Rationale of technical requirements for NRG-BR001: The first NCI-sponsored trial of SBRT for the treatment of multiple metastases

Hania A. Al-Hallaq et al.

PRACTICAL RADIATION ONCOLOGY (2016)

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Article Oncology

Three-Dimensional Radiation Therapy to the Primary Tumor With Concurrent Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer: Results of a Multicenter Phase 2 Study From PPRA-RTOG, China

ShengFa Su et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2015)

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Article Oncology

A randomized phase III trial of stereotactic radiosurgery (SRS) versus observation for patients with asymptomatic cerebral oligo-metastases in non-small-cell lung cancer

S. H. Lim et al.

ANNALS OF ONCOLOGY (2015)

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Article Oncology

Phase II study of stereotactic body radiotherapy to primary tumor and metastatic locations in oligometastatic nonsmall-cell lung cancer patients

C. Collen et al.

ANNALS OF ONCOLOGY (2014)

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Article Oncology

An Individual Patient Data Metaanalysis of Outcomes and Prognostic Factors After Treatment of Oligometastatic Non-Small-Cell Lung Cancer

Allison B. Ashworth et al.

CLINICAL LUNG CANCER (2014)

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Article Oncology

The oligometastatic state-separating truth from wishful thinking

David A. Palma et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2014)

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Review Oncology

Is there an oligometastatic state in non-small cell lung cancer? A systematic review of the literature

Allison Ashworth et al.

LUNG CANCER (2013)

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Article Oncology

Radical Treatment of Non-Small-Cell Lung Cancer Patients with Synchronous Oligometastases Long-Term Results of a Prospective Phase II Trial (Nct01282450)

Dirk De Ruysscher et al.

JOURNAL OF THORACIC ONCOLOGY (2012)

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Review Respiratory System

Oligometastatic Disease at Presentation or Recurrence for Nonsmall Cell Lung Cancer

Daniel R. Gomez et al.

PULMONARY MEDICINE (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Stereotactic body radiation therapy: The report of AAPM Task Group 101

Stanley H. Benedict et al.

MEDICAL PHYSICS (2010)

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Review Health Care Sciences & Services

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2009)

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Article Oncology

Laparoscopic adrenalectomy for isolated adrenal metastasis

Vivian E. Strong et al.

ANNALS OF SURGICAL ONCOLOGY (2007)

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Review Radiology, Nuclear Medicine & Medical Imaging

The management of respiratory motion in radiation oncology report of AAPM Task Group 76

Paul J. Keall et al.

MEDICAL PHYSICS (2006)

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Treatment of Oligometastatic Non-Small Cell Lung Cancer: An ASTRO/ESTRO Clinical Practice Guideline

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