期刊
LIFE SCIENCES
卷 151, 期 -, 页码 76-85出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2016.02.094
关键词
Anesthetics; Nitric oxide/nitric oxide synthase; Propofol; Ketamine; Sevoflurane; Isoflurane; Organ protection
资金
- National Natural Science Foundation of China [81271166, 81371107, 81470760]
- Natural Science Foundation of Guangdong Province [S2013010015888]
- Fundamental Research Funds for the Central Universities [11ykpy50]
- International Science and Technological Cooperation Program in Dongguan City [2013508152011, 2013508152002]
Nitric oxide (NO) is a free radical gas in the biological system, which is produced by nitric oxide synthase (NOS) family. NO acts as a biological mediator and plays important roles in different systems in humans. The NO/NOS system exerts a broad spectrum of signaling functions involved in vasodilation, inflammation, oxidative stress, cardioprotection and neuroprotection. It has been demonstrated that intravenous and volatile anesthetics (such as propofol, ketamine, midazolam, isoflurane, sevoflurane, and desflurane, etc.) modulate NO production through multiple mechanisms that may influence physiological and pathophysiological processes. This review focuses on the effects of different anesthetics on NO/NOS regulation in different disease conditions. Possible cellular mechanisms and intermediate role of NO/NOS in anesthetic-mediated organ protection are also discussed. It would be interesting to clarify the impact of anesthetics on NO/NOS regulation. This review gives an overview of the effects of different anesthetics on NO/NOS regulation and function in different physiologic and pathophysiologic states. (C) 2016 Elsevier Inc. All rights reserved.
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