The Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine, a Complex Phenomenon: A Narrative Review

As warned by Sir Alexander Fleming in his Nobel Prize address: the use of antimicrobials can, and will, lead to resistance. Antimicrobial resistance (AMR) has recently increased due to the overuse and misuse of antibiotics, and their use in animals (food-producing and companion) has also resulted in the selection and transmission of resistant bacteria. The epidemiology of resistance is complex, and factors other than the overall quantity of antibiotics consumed may influence it. Nowadays, AMR has a serious impact on society, both economically and in terms of healthcare. This narrative review aimed to provide a scenario of the state of the AMR phenomenon in veterinary medicine related to the use of antibiotics in different animal species; the impact that it can have on animals, as well as humans and the environment, was considered. Providing some particular instances, the authors tried to explain the vastness of the phenomenon of AMR in veterinary medicine due to many and diverse aspects that cannot always be controlled. The veterinarian is the main reference point here and has a high responsibility towards the human-animal-environment triad. Sharing such a burden with human medicine and cooperating together for the same purpose (fighting and containing AMR) represents an effective example of the application of the One Health approach.

Automated summary

As warned by Sir Alexander Fleming in his Nobel Prize address, the overuse and misuse of antibiotics, as well as their use in animals, have led to an increase in antimicrobial resistance (AMR) which has serious impacts on society both economically and in terms of healthcare. This review provides an overview of the state of AMR phenomenon in veterinary medicine and its impact on animals, humans, and the environment. It emphasizes the responsibility of veterinarians in the human-animal-environment triad and the importance of collaboration between veterinary and human medicine in the fight against AMR.