期刊
LIFE SCIENCES
卷 157, 期 -, 页码 52-61出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2016.05.036
关键词
Src; EMT; Vascular permeability; Microinvasion; Metastasis
资金
- National Institutes of Health [R01HL103952]
- University of Georgia Research Foundation
- UGA-College of Pharmacy Dean's Foundation
- Departmental Translational Research Initiative
The Src-family kinases (SFKs), an intracellularly located group of non-receptor tyrosine kinases are involved in oncogenesis. The importance of SFKs has been implicated in the promotion of tumor cell motility, proliferation, inhibition of apoptosis, invasion and metastasis. Recent evidences indicate that specific effects of SFKs on epithelial-to-mesenchymal transition (EMT) as well as on endothelial and stromal cells in the tumor microenvironment can have profound effects on tumor microinvasion and metastasis. Although, having been studied extensively, these novel features of SFKs may contribute to greater understanding of benefits from Src inhibition in various types of cancers. Here we review the novel role of SFKs, particularly c-Src in mediating EMT, modulation of tumor endothelial-barrier, transendothelial migration (microinvasion) and metastasis of cancer cells, and discuss the utility of Src inhibitors in vascular normalization and cancer therapy. (C) 2016 Elsevier Inc. All rights reserved.
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