期刊
FOODS
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/foods12050926
关键词
curcumin derivative; melanogenesis; MC1R signaling pathway; zebrafish; melanin production; whitening agent
Regulation of melanin production through the MC1R signaling pathway is an important protective mechanism against UV exposure. The search for skin-whitening agents has been a major pursuit of the cosmetic industry, and the potential of curcumin and its derivatives, dimethoxycurcumin and bisdemethoxycurcumin, was evaluated in this study. Curcumin and bisdemethoxycurcumin showed significant antimelanogenic activities in melanoma cells and zebrafish embryos. However, the highest concentration of curcumin resulted in slight toxicity in zebrafish embryos, while dimethoxycurcumin had no activity. Bisdemethoxycurcumin appears to be a strong candidate as a skin-whitening agent.
Regulation of melanin production via the MC1R signaling pathway is a protective mechanism of the skin of living organisms against exposure to ultraviolet rays. The discovery of human skin-whitening agents has been one of the most intense pursuits of the cosmetic industry. The MC1R signaling pathway is activated by its agonist, alpha-melanocyte stimulating hormone (alpha-MSH), and mainly regulates melanogenesis. Here, we evaluated the antimelanogenic activities of curcumin (CUR) and its two derivatives, dimethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), in B16F10 mouse melanoma cells and zebrafish embryos. CUR and BDMC reduced the alpha-MSH-induced melanin production in B16F10 cells and also downregulated the expression of the melanin-production-related genes Tyr, Mitf, Trp-1, and Trp-2. Moreover, the biological activity of these two compounds against melanogenesis was confirmed in in vivo experiments using zebrafish embryos. However, the highest concentration of CUR (5 mu M) resulted in slight malformations in zebrafish embryos, as indicated by acute toxicity tests. In contrast, DMC did not show any biological activity in vitro or in vivo. Conclusively, BDMC is a strong candidate as a skin-whitening agent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据