期刊
FOODS
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/foods12050921
关键词
curcumin; curcuminoids; chronic renal disease; cardiovascular disease (CVD); dyslipidemia; CKD
Chronic kidney disease is a growing health problem characterized by diverse symptomatology, including dyslipidemia. Dyslipidemia increases the risk of cardiovascular diseases and mortality in CKD patients. It is necessary to explore new therapies, such as curcuminoids, to mitigate the use of medications in CKD treatment.
Chronic kidney disease (CKD) is a health problem that is constantly growing. This disease presents a diverse symptomatology that implies complex therapeutic management. One of its characteristic symptoms is dyslipidemia, which becomes a risk factor for developing cardiovascular diseases and increases the mortality of CKD patients. Various drugs, particularly those used for dyslipidemia, consumed in the course of CKD lead to side effects that delay the patient's recovery. Therefore, it is necessary to implement new therapies with natural compounds, such as curcuminoids (derived from the Curcuma longa plant), which can cushion the damage caused by the excessive use of medications. This manuscript aims to review the current evidence on the use of curcuminoids on dyslipidemia in CKD and CKD-induced cardiovascular disease (CVD). We first described oxidative stress, inflammation, fibrosis, and metabolic reprogramming as factors that induce dyslipidemia in CKD and their association with CVD development. We proposed the potential use of curcuminoids in CKD and their utilization in clinics to treat CKD-dyslipidemia.
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