Practical aspects of the diagnosis and management of pyoderma gangrenosum

Letter Dermatology

Evaluating the role of histopathology in diagnosing pyoderma gangrenosum using Delphi and PARACELSUS criteria: a multicentre, retrospective cohort study

Michelle S. Min et al.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Letter Dermatology

Wound care dressings for pyoderma gangrenosum

Jennifer L. Strunck et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Editorial Material Medicine, General & Internal

A rapidly progressing, painful ulcer at a surgical wound site

Shijia Rao et al.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Review Oncology

Tyrosine kinase inhibitors-associated pyoderma gangrenosum, a systematic review of published case reports

Niloofar Khoshnam-Rad et al.

Summary: Pyoderma gangrenosum is a rare ulcerative dermatosis that can be caused by some drugs, including small molecule tyrosine kinase inhibitors (TKIs). This study evaluated the reported evidence of pyoderma gangrenosum associated with TKI use. Through a systematic electronic literature search, fifteen case reports associated with different TKIs were identified. The average Naranjo score of these cases was 6.6, indicating a probable adverse drug reaction. Detailed medical history can help prompt the diagnosis of drug-induced pyoderma gangrenosum. Clinicians should be aware of TKI-associated pyoderma gangrenosum in oncologic patients undergoing kinase inhibitor therapy.

ANTI-CANCER DRUGS (2022)

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Review Dermatology

International Dermatology Outcome Measures (IDEOM): Report from the 2020 Annual Meeting

Alison H. Kohn et al.

Summary: This report summarizes the work presented by each IDEOM workgroup (psoriasis, psoriatic arthritis, hidradenitis suppurativa, acne, pyoderma gangrenosum, and actinic keratosis) at the 2020 IDEOM Virtual Annual Meeting.

DERMATOLOGY (2022)

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Article Cell Biology

Pyoderma gangrenosum study pilot registry: The first step to a better understanding

Victoria E. Orfaly et al.

Summary: The objective of this study was to develop a physician-driven patient registry for pyoderma gangrenosum (PG) to collect patient demographics, medical history, treatments, and outcomes. The pilot study found that the use of systemic immunomodulators was associated with healing of PG patients. Standardization of wound care regimens and data collection is crucial for evaluating treatment outcomes in PG.

WOUND REPAIR AND REGENERATION (2022)

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Article Dermatology

Comparison of Three Diagnostic Frameworks for Pyoderma Gangrenosum

Carter Haag et al.

Summary: This study evaluated and compared the concordance of three different PG diagnostic frameworks within a cohort of 47 patients, finding that the PARACELSUS score identified the highest proportion of PG patients at 89%. The study highlights the need for future research to refine these diagnostic frameworks and identify targeted testing methods to reduce misdiagnosis rates and patient misclassification in clinical trials.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Dermatology

Applying Intravenous Immunoglobulin and Negative-Pressure Wound Therapy to Treat Refractory Pyoderma Gangrenosum: A Case Report

Shi-Ying Jin et al.

Summary: In cases of refractory PG, the use of intravenous immunoglobulin as an effective adjuvant treatment is supported, while negative-pressure wound therapy is shown to be a treatment option to accelerate ulcer healing under adequate immunosuppression.

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS (2021)

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Review Dermatology

Phenotypic Associations of PSTPIP1 Sequence Variants in PSTPIP1-Associated Autoinflammatory Diseases

Guilaine Boursier et al.

Summary: Pathogenic variants in the PSTPIP1 gene can cause PAPA syndrome, but only a small percentage of the identified variants are pathogenic. These variants are associated with different clinical expressions in patients with PAIDs.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Letter Rheumatology

Pyoderma gangrenosum induced by adalimumab in a seropositive rheumatoid arthritis patient: a paradoxical effect of adalimumab?

Yvonne Tan et al.

RHEUMATOLOGY (2021)

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Article Cell Biology

The surgical approach to Pyoderma gangrenosum: A retrospective monocenter study

Alperen S. Bingoel et al.

Summary: Pyoderma gangrenosum is a rare and frequently misdiagnosed disease that can result in severe tissue loss. Surgical treatments, such as debridements and skin grafts, are necessary for reconstruction once the wound progression is controlled. Drug-based therapy can stop the progress of the disease, but reconstructive-surgical treatments are an important component of therapy for selected patients.

WOUND REPAIR AND REGENERATION (2021)

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Review Cell Biology

The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience

Ivan R. Almeida et al.

Summary: Pyoderma gangrenosum (PG) is a rare and painful skin disease, and the use of negative pressure wound therapy (NPWT) in its treatment remains controversial due to the risk of pathergy. However, a systematic review showed that NPWT, when combined with immunosuppressive therapy, can improve wound healing in the majority of cases. Therefore, NPWT could be considered a safe option for treating PG wounds, especially when combined with systemic immunosuppression and skin grafting.

WOUND REPAIR AND REGENERATION (2021)

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Letter Dermatology

Challenging the association of hepatitis C and pyoderma gangrenosum

D. Croitoru et al.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Dermatology

A Systematic Review of Depression and Anxiety in Adults with Pyoderma Gangrenosum

Meghan L. McPhie et al.

Summary: The evidence synthesis on anxiety and depression prevalence in adults with pyoderma gangrenosum (PG) showed that depression is a common psychological comorbidity in this patient population, with estimated rates ranging from 10% to 23%. However, none of the included studies measured rates of anxiety, indicating a need for further research in this area.

ADVANCES IN SKIN & WOUND CARE (2021)

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Article Dermatology

Pyoderma Gangrenosum: A Retrospective Study of Clinical Characteristics, Comorbidities, Response to Treatment and Mortality Related to Prednisone Dose

Louise Schosler et al.

Summary: Pyoderma gangrenosum is a rare ulcerative neutrophilic dermatosis with diverse clinical presentations and challenging treatment. Accompanying comorbidities, including diabetes, were commonly found in patients. Tumor necrosis factor α inhibitors showed the shortest time to remission as a third- or fourth-line therapy, while the use of prednisone was associated with a higher mortality rate.

ACTA DERMATO-VENEREOLOGICA (2021)

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Letter Dermatology

Imatinib-induced pyoderma gangrenosum in a patient with chronic myeloid leukemia

Andrea Giuseppe Faraci et al.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2021)

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Article Surgery

An extensive pyoderma gangrenosum mimicking necrotizing fasciitis: An unusual case report

Mehmet Aziret et al.

Summary: Pyoderma Gangrenosum is a rare inflammatory disease characterized by ulcerative skin lesions, often occurring after surgeries such as bowel, breast, or C-section. Prompt diagnosis and treatment can reduce morbidity and complications associated with PG.

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS (2021)

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Editorial Material Surgery

Post-surgical pyoderma gangrenosum of the breast: a diagnostic dilemma?

Edgardo Solis et al.

ANZ JOURNAL OF SURGERY (2020)

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Article Dermatology

Prevalence estimates for pyoderma gangrenosum in the United States: An age- and sex-adjusted population analysis

Amy Xu et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Cell Biology

The utility and challenges of histopathologic evaluation in the diagnosis of nonmalignant skin ulcers

Phoebe Hammer et al.

WOUND REPAIR AND REGENERATION (2020)

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Article Dermatology

Perioperative management of pyoderma gangrenosum

Carter K. Haag et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Gastroenterology & Hepatology

Risk factors and treatment outcomes of peristomal pyoderma gangrenosum in patients with inflammatory bowel disease

Jingzhou Wang et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

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Review Dermatology

Identification and evaluation of outcome measurement instruments in pyoderma gangrenosum: a systematic review

J. D. Lu et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Article Dermatology

PG-TIME: A practical approach to the clinical management of pyoderma gangrenosum

Agata Janowska et al.

DERMATOLOGIC THERAPY (2020)

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Review Pharmacology & Pharmacy

Diagnosis and novel clinical treatment strategies for pyoderma gangrenosum

Mohamad Goldust et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2020)

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Article Dermatology

Pyoderma gangrenosum: From historical perspectives to emerging investigations

Misty M. Hobbs et al.

INTERNATIONAL WOUND JOURNAL (2020)

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Review Dermatology

Surgical Treatment of Pyoderma Gangrenosum with Negative Pressure Wound Therapy and Skin Grafting, Including Xenografts: Personal Experience and Comprehensive Review on 161 Cases

Klaus Eisendle et al.

ADVANCES IN WOUND CARE (2020)

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Letter Dermatology

Refractory steroid-resistant pyoderma gangrenosum successfully treated with intravenous immunoglobulins

Igor Kapetanovic et al.

DERMATOLOGIC THERAPY (2020)

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Article Medicine, General & Internal

Pyoderma gangrenosum

Emanual Maverakis et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Article Dermatology

The PARACELSUS score: a novel diagnostic tool for pyoderma gangrenosum

F. Jockenhoefer et al.

BRITISH JOURNAL OF DERMATOLOGY (2019)

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Letter Dermatology

Epidemiology of pyoderma gangrenosum in Japanese patients by questionnaire survey

Toshiyuki Yamamoto

JOURNAL OF DERMATOLOGY (2019)

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Review Dermatology

Extracutaneous involvement of pyoderma gangrenosum

Luis J. Borda et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2019)

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Letter Dermatology

Pyoderma gangrenosum misdiagnosed as necrotising fasciitis or a real association between the two?

P. Cirotteau et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Article Dermatology

Age-specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children

M. Bucchia et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Review Immunology

Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases

Angelo V. Marzano et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Dermatology

Necrotising fasciitis or pyoderma gangrenosum: A fatal dilemma

Cenk Demirdover et al.

INTERNATIONAL WOUND JOURNAL (2019)

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Editorial Material Dermatology

Rare Presentation of Postsurgical Pyoderma Gangrenosum Presenting as Necrotizing Soft Tissue Infection

Rod L. Flynn et al.

ADVANCES IN SKIN & WOUND CARE (2019)

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Review Critical Care Medicine

Pyoderma gangrenosum misdiagnosis resulting in amputation: A review

Carter K. Haag et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2019)

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Review Dermatology

Underlying Systemic Diseases in Pyoderma Gangrenosum: A Systematic Review and Meta-Analysis

Khalaf Kridin et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2018)

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Review Dermatology

Intravenous immunoglobulin as adjunct therapy for refractory pyoderma gangrenosum: systematic review of cases and case series

H. Song et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Article Surgery

Reconstructive microsurgical approach for the treatment of pyoderma gangrenosum

Karl Schwaiger et al.

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY (2018)

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Article Dermatology

Risk of developing pyoderma gangrenosum after procedures in patients with a known history of pyoderma gangrenosum-A retrospective analysis

Fan Di Xia et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Review Dermatology

Pyoderma gangrenosum in an infant: A case report and review of the literature

Lauren Crouse et al.

PEDIATRIC DERMATOLOGY (2018)

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Review Medicine, Research & Experimental

New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance

Ephraim L. Tsalik et al.

ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

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Article Dermatology

Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum A Delphi Consensus of International Experts

Emanual Maverakis et al.

JAMA DERMATOLOGY (2018)

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Article Dermatology

The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum

Hovik J. Ashchyan et al.

JAMA DERMATOLOGY (2018)

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Article Dermatology

A case of chronic ulcer due to subcutaneous arteriolosclerosis in an obese patient mimicking pyoderma gangrenosum

Sezin Ficicioglu et al.

DERMATOLOGY REPORTS (2018)

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Review Dermatology

Drug-Induced Pyoderma Gangrenosum: A Review

Jane Y. Wang et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2018)

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Review Allergy

A Comprehensive Review of Neutrophilic Diseases

Angelo V. Marzano et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2018)

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Article Dermatology

Combination of negative pressure wound therapy and systemic steroid therapy in postsurgical pyoderma gangrenosum after reduction mammoplasty; a case of proven efficacy and safety

Sara Tanini et al.

DERMATOLOGY REPORTS (2017)

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Review Dermatology

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum

B. C. Wu et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

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Review Dermatology

PAPA, PASH and PAPASH Syndromes: Pathophysiology, Presentation and Treatment

Massimo Cugno et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2017)

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Review Dermatology

Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment

Afsaneh Alavi et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2017)

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Letter Dermatology

Treatment of pyoderma gangrenosum: retrospective multicentre analysis of 121 patients

K. Herberger et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

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Review Dermatology

Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review

Forum Patel et al.

ACTA DERMATO-VENEREOLOGICA (2015)

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Article Medicine, General & Internal

Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial

Anthony D. Ormerod et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Article Medicine, General & Internal

Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial

Anthony D. Ormerod et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Article Dermatology

Gulliver's sign: A recognizable transition from inflammatory to healing stages of pyoderma gangrenosum

Erin T. Landis et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2015)

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Article Dermatology

Malignant pyoderma gangrenosum eroding the parotid gland successfully treated with dexamethasone pulse therapy

Betsy Ambooken et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2014)

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Review Dermatology

Etiology and Management of Pyoderma Gangrenosum A Comprehensive Review

Iris Ahronowitz et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2012)

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Article Dermatology

Incidence, Mortality, and Disease Associations of Pyoderma Gangrenosum in the United Kingdom: A Retrospective Cohort Study

Sinead M. Langan et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

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Article Medicine, Research & Experimental

UK Dermatology Clinical Trials Network's STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial

Fiona F. Craig et al.

TRIALS (2012)

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Article Dermatology

Is Topical Monotherapy Effective for Localized Pyoderma Gangrenosum?

Laurence Le Cleach et al.

ARCHIVES OF DERMATOLOGY (2011)

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Article Dermatology

Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients

A. M. Binus et al.

BRITISH JOURNAL OF DERMATOLOGY (2011)

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Review Dermatology

Clinical features of pyoderma gangrenosum and current diagnostic trends

Ahmed Hadi et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2011)

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Article Immunology

Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases

A. V. Marzano et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)

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Review Dermatology

Pyoderma gangrenosum: an updated review

E. Ruocco et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2009)

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Article Gastroenterology & Hepatology

Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial

TN Brooklyn et al.

GUT (2006)

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Review Dermatology

Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria

WPD Su et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2004)

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Article Medicine, General & Internal

Skin ulcers misdiagnosed as pyoderma gangrenosum

RH Weenig et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Letter Dermatology

Pyoderma gangrenosum in pregnancy

S Aytekin et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2002)

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Review Biochemistry & Molecular Biology

Molecular detection and genotyping of pathogens: more accurate and rapid answers

J Versalovic et al.

TRENDS IN MICROBIOLOGY (2002)

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Article Medicine, General & Internal

Clinical features and treatment of peristomal pyoderma grangrenosum

AP Hughes et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)

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Practical aspects of the diagnosis and management of pyoderma gangrenosum

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