4.6 Review

Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Microbiology

Animal models for dissecting Vibrio cholerae intestinal pathogenesis and immunity

Brandon Sit et al.

Summary: This article reviews non-surgical animal models currently used to study cholera, highlighting recent discoveries in the mechanisms of cholera pathogenesis and immunity, particularly in relation to the interaction between Vibrio cholerae and the gut microbiome.

CURRENT OPINION IN MICROBIOLOGY (2022)

Article Immunology

Update on CVD 103-HgR single-dose, live oral cholera vaccine

James McCarty et al.

Summary: Vaxchora vaccine has shown 90% efficacy in clinical trials, has been licensed for use in children and adults in the United States and Europe, and no new safety issues have been identified after over 68,000 doses administered. Adjustments have been made in both dose volume and cold chain requirements for the vaccine.

EXPERT REVIEW OF VACCINES (2022)

Article Immunology

Immunogenic efficacy of DNA and protein-based vaccine from a chimeric gene consisting OmpW, TcpA and CtxB, of Vibrio cholerae

Tahereh Zareitaher et al.

Summary: The study evaluated the immunogenicity and specificity of DNA and protein vaccines against Vibrio cholerae, demonstrating potential protective effects in terms of cytotoxicity, cell adhesion, and spleen cell viability.

IMMUNOBIOLOGY (2022)

Article Immunology

Structure, regulation, and host interaction of outer membrane protein U (OmpU) of Vibrio species

Hilal A. Ganie et al.

Summary: OmpU is a key outer membrane protein that interacts with host cells, playing an important role in immune response, cell death, and cytoskeletal reorganization.

MICROBIAL PATHOGENESIS (2022)

Article Immunology

A non-inferiority trial comparing two killed, whole cell, oral cholera vaccines (Cholvax vs. Shanchol) in Dhaka, Bangladesh

Fahima Chowdhury et al.

Summary: Bangladesh remains endemic to cholera and experiences biannual epidemics causing severe cases and deaths. A locally manufactured oral cholera vaccine named Cholvax was tested and found to be safe and non-inferior to the licensed vaccine Shanchol in terms of immunogenicity. This supports the use of Cholvax in Bangladesh to reduce the cholera burden.

VACCINE (2022)

Review Public, Environmental & Occupational Health

Drought-related cholera outbreaks in Africa and the implications for climate change: a narrative review

Gina E. C. Charnley et al.

Summary: Africa has historically experienced periods of prolonged and extreme droughts, leading to food insecurity, social inequity, and high mortality rates. Droughts can exacerbate infectious disease outbreaks, such as cholera, due to factors like malnutrition, poor access to water and sanitation, and population displacement. Future climate change could increase the frequency and duration of droughts, potentially worsening cholera outbreaks in Africa.

PATHOGENS AND GLOBAL HEALTH (2022)

Article Chemistry, Medicinal

Virus-like Particle Display of Vibrio cholerae O-Specific Polysaccharide as a Potential Vaccine against Cholera

Zahra Rashidijahanabad et al.

Summary: A potential conjugate vaccine was developed by efficiently linking O-specific polysaccharide antigen with Q beta virus-like particles. The vaccine generated long-lasting immune responses and recognized the native lipopolysaccharide from Vibrio cholerae.

ACS INFECTIOUS DISEASES (2022)

Article Immunology

A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa

Owen Jensen et al.

Summary: Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that protect mucosal surfaces against bacterial pathogens. They not only release inflammatory cytokines and cytotoxic molecules but also provide B cell help. This study identifies a population of CXCR5(+) T follicular helper-like MAIT cells (MAITfh) that can provide B cell help within mucosal lymphoid organs.

SCIENCE IMMUNOLOGY (2022)

Article Infectious Diseases

Cholera outbreaks in sub-Saharan Africa during 2010-2019: A Descriptive Analysis

Qulu Zheng et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Review Environmental Sciences

Cholera Outbreaks in India, 2011-2020: A Systematic Review

Basilua Andre Muzembo et al.

Summary: This systematic review examines the drivers of cholera outbreaks in India between 2011 and 2020. The results indicate that contaminated drinking water and food, inadequate sanitation and hygiene (including open defecation), and direct contact between households are the main drivers of cholera outbreaks. Additionally, there is a decreasing trend in outbreaks caused by damaged water pipelines. The issues of open defecation, sanitation, and clean water access still pose challenges in India and should be addressed.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Infectious Diseases

Mucosal-Associated Invariant T (MAIT) cells are highly activated in duodenal tissue of humans with Vibrio cholerae O1 infection: A preliminary report

Taufiqur R. Bhuiyan et al.

Summary: During cholera infection, MAIT cells are present in the lamina propria of the duodenum, more activated, and their loss is correlated with intestinal permeability and inflammation.

PLOS NEGLECTED TROPICAL DISEASES (2022)

Review Microbiology

Emerging Concepts in Cholera Vaccine Design

Brandon Sit et al.

Summary: Cholera, caused by Vibrio cholerae, is a severe diarrheal disease that poses a significant public health threat in many parts of the world. Recent advancements in oral and nonoral cholera vaccine platforms have opened up new opportunities for vaccine design and implementation. As a preventable disease, cholera remains an important area for the development and application of cutting-edge technologies and platforms.

ANNUAL REVIEW OF MICROBIOLOGY (2022)

Article Multidisciplinary Sciences

A polyvalent multiepitope protein cross-protects against Vibrio cholerae infection in rabbit colonization and passive protection models

Ipshita Upadhyay et al.

Summary: By using a multiepitope fusion antigen vaccinology platform, researchers constructed a polyvalent protein immunogen that can induce immune response and cross-protection. The immunogen was shown to generate antibodies against various virulence factors of Vibrio cholerae and provide protection against bacterial colonization and related diseases.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Review Microbiology

Diagnosis, Management, and Future Control of Cholera

Fahima Chowdhury et al.

Summary: Cholera is a persistent disease in developing countries due to inadequate access to safe water, sanitation, and hygiene. It is transmitted through contaminated food or water and can lead to severe dehydration and even shock. Prompt rehydration and antibiotic treatment, along with oral cholera vaccines, are crucial in reducing the mortality rate.

CLINICAL MICROBIOLOGY REVIEWS (2022)

Article Biotechnology & Applied Microbiology

Genetically modified potato and rice based edible vaccines-An overview

Pranjali Gupta et al.

Summary: This review comprehensively summarizes the research on rice and potato-derived edible vaccines, elaborating on the studies conducted since 1995 for various diseases. It focuses solely on potato and rice based studies.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2022)

Review Immunology

Mucosal and systemic immune responses to Vibrio cholerae infection and oral cholera vaccines (OCVs) in humans: a systematic review

Akshayata Naidu et al.

Summary: In this article, the authors review clinical trials focusing on the early transcriptional mucosal responses elicited during Vibrio cholerae infection and vaccination. They also summarize the various components of the effector immune response against Vibrio cholerae. The currently licensed killed/inactivated vaccines may have limited efficacy in endemic settings due to their inability to elicit key inflammatory pathways locally. Further studies are needed to understand the immunogenicity of live attenuated cholera vaccines in these regions. Various extrinsic and intrinsic factors influence anti-cholera immunity and should be considered for the development of region-specific next-generation vaccines.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes

Rupert L. Mayer et al.

Summary: The authors used immunopeptidomics to identify bacterial peptides presented on infected cells and identified antigens that provided protection in mice when used as mRNA vaccine.

NATURE COMMUNICATIONS (2022)

Article Infectious Diseases

Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial

Yoshikazu Yuki et al.

Summary: The study evaluated the safety, tolerability, and immunogenicity of MucoRice-CTB in humans. Results showed that 6 g MucoRice-CTB helped increase serum IgG and IgA antibody concentrations against CTB.

LANCET MICROBE (2021)

Article Biochemistry & Molecular Biology

σE controlled regulation of porin OmpU in Vibrio cholerae

Nina Pennetzdorfer et al.

Summary: This study reveals the importance of OmpU in Vibrio cholerae and the mechanism by which sigma(E) regulates OmpU synthesis, demonstrating a negative feedback regulation circuit of OmpU expression.

MOLECULAR MICROBIOLOGY (2021)

Article Immunology

Scalable production and immunogenicity of a cholera conjugate vaccine

Suhi Jeon et al.

Summary: There is a need for cholera vaccines that provide long-term immunity in young children, who have poor immunological responses to certain antigens. The development of CCV shows promise in addressing this challenge and inducing adequate protection in young children.

VACCINE (2021)

Article Public, Environmental & Occupational Health

Parenteral Vaccination with a Cholera Conjugate Vaccine Boosts Vibriocidal and Anti-OSP Responses in Mice Previously Immunized with an Oral Cholera Vaccine

Aklima Akter et al.

Summary: The study shows that a combination of oral cholera vaccination followed by parenteral cholera conjugate vaccine boosting can significantly enhance immune responses and potentially improve protection against cholera.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2021)

Review Infectious Diseases

Evolution, distribution and genetics of atypical Vibrio cholerae - A review

Murari Bhandari et al.

Summary: Vibrio cholerae is the etiological agent of cholera, a severe diarrheal disease that can occur as either an epidemic or sporadic disease. Current seventh pandemic strains of Atypical El Tor V. cholerae show higher severity in pathophysiology compared to El Tor or classical strains.

INFECTION GENETICS AND EVOLUTION (2021)

Article Immunology

Oral Cholera Vaccine Efficacy and Effectiveness

Katerina Rok Song et al.

Summary: Both efficacy and effectiveness studies of vaccines help to understand the impact of vaccines in real-world settings, with vaccines used in public health programs potentially showing higher effectiveness due to indirect herd protection.

VACCINES (2021)

Article Multidisciplinary Sciences

A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae

John C. Macbeth et al.

Summary: The composition of the gut microbiome at the time of infection or vaccination appears to be crucial for providing robust mucosal immunity against Vibrio cholerae. In cholera-endemic areas, dysbiotic human gut microbiomes may suppress the immune response against V. cholerae via CD4+ lymphocytes.

ISCIENCE (2021)

Review Immunology

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function

Urs M. Morbe et al.

Summary: Human GALT, including Peyer's patches, appendix, and ILF, plays a key role in antigen sampling and adaptive immune responses in the intestinal wall. Current understanding of human GALT is primarily based on studies in mice, and its relevance to human health remains unclear. Further research is needed to explore the structure, composition, and potential regulatory functions of human GALT in intestinal immune responses.

MUCOSAL IMMUNOLOGY (2021)

Article Immunology

Modern History of Cholera Vaccines and the Pivotal Role of icddr,b

Jan Holmgren

Summary: The rapid spread of the seventh cholera pandemic in the 1960s revealed the poor efficacy of traditional injectable cholera vaccines, leading WHO to stop recommending cholera vaccination, and spurred the development of effective orally administered cholera vaccines that are now a key part of WHO's strategy for ending cholera by 2030.

JOURNAL OF INFECTIOUS DISEASES (2021)

Article Immunology

A phase I/II study to evaluate safety, tolerability and immunogenicity of Hillchol®, an inactivated single Hikojima strain based oral cholera vaccine, in a sequentially age descending population in Bangladesh

Fahima Chowdhury et al.

Summary: The study evaluated the safety and immunogenicity of the new OCV Hillchol compared to Shanchol in a cholera-endemic setting, showing that Hillchol was non-inferior to Shanchol in terms of serum vibriocidal antibody responses.

VACCINE (2021)

Article Microbiology

Outer Membrane Vesicles of Vibrio cholerae Protect and Deliver Active Cholera Toxin to Host Cells via Porin-Dependent Uptake

Franz G. Zingl et al.

Summary: Outer membrane vesicles (OMVs) play a crucial role in the delivery and protection of bioactive substances such as cholera toxin, facilitating their uptake by intestinal cells. OMVs produced by V. cholerae can carry cholera toxin to host intestinal cells via endocytosis mediated by specific outer membrane porins, and the toxin remains active in the presence of intestinal proteases due to protection by OMVs. This extended half-life of vesicle-associated cholera toxin may allow it to target distant host cells within the intestinal tract.
Review Infectious Diseases

Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review

Tiffany Leung et al.

Summary: Studies show that there is strong evidence of protection at 3 years after cholera infection, but humoral markers return to baseline within 1 year. Subclinical cholera infection may provide lower protection than clinical infection, as indicated by research findings. Further studies are needed to understand the differences in protection provided by different types of cholera infections.

PLOS NEGLECTED TROPICAL DISEASES (2021)

Review Pharmacology & Pharmacy

Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases

Seyed Davoud Jazayeri et al.

Summary: Mucosal surfaces are the initial site of infection for most diseases, making oral vaccination crucial for providing protection as the first line of defense through stimulation of immune responses at both systemic and mucosal levels. Successful oral vaccines must overcome the challenges posed by the harsh gastrointestinal environment and low immunogenicity, which can be addressed through the development of delivery systems and adjuvants like nanoparticles and microparticles.

FRONTIERS IN PHARMACOLOGY (2021)

Article Immunology

Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines

Aqel Albutti et al.

Summary: Oral vaccination offers potential benefits for protection against enteric pathogens by inducing intestinal immune responses in addition to systemic immunity, but lacks potent and safe oral adjuvants for clinical use. Sulfatide has been demonstrated as an effective oral adjuvant for enhancing the effects of an oral cholera vaccine, showing promise for new vaccine strategies targeting NKT cells.

VACCINES (2021)

Letter Public, Environmental & Occupational Health

Dual tension as Nigeria battles cholera during the COVID-19 pandemic

Shuaibu Saidu Musa et al.

CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH (2021)

Article Public, Environmental & Occupational Health

Reactive mass vaccination campaign against cholera in the COVID-19 context in Cameroon: challenges, best practices and lessons learned

Adidja Amani et al.

Summary: This study summarizes the challenges, best practices, and lessons learned from a reactive cholera vaccination campaign in Cameroon. The vaccination coverage rate was 64.4% with a refusal rate ranging from 0-10% across different health districts. The main challenge identified was difficulty in maintaining physical distancing, and the best practice was screening all participants receiving the COVID-19 vaccination. Proper population sensitization and scheduling during favorable climate seasons were found to be crucial for achieving good vaccination coverage.

PAN AFRICAN MEDICAL JOURNAL (2021)

Review Gastroenterology & Hepatology

The Interface of Vibrio cholerae and the Gut Microbiome

Jennifer Y. Cho et al.

Summary: Recent studies have shown that the structure and function of the gut microbiome can influence the virulence gene regulation, metabolism, and host immune responses to Vibrio cholerae infection and vaccination, offering new perspectives in the design of prophylactic and therapeutic approaches for cholera control.

GUT MICROBES (2021)

Article Infectious Diseases

An Update on Cholera Immunity and Current and Future Cholera Vaccines

Jan Holmgren

Summary: Individual resistance to cholera infection and disease depends on both innate host factors and adaptive immunity. Oral cholera vaccines have been proven to be safe and effective in all settings and are recommended by the World Health Organisation (WHO) for the control of cholera outbreaks.

TROPICAL MEDICINE AND INFECTIOUS DISEASE (2021)

Review Infectious Diseases

Licensed and Recommended Inactivated Oral CholeraVaccines: From Development to Innovative Deployment

Jacqueline Deen et al.

Summary: Cholera is a disease associated with poverty, and vaccination has become an important additional tool for prevention and control due to the challenges in improving water supply and sanitation infrastructure. Oral cholera vaccines have been developed with safety, efficacy, and a global stockpile, but limited supply remains an issue.

TROPICAL MEDICINE AND INFECTIOUS DISEASE (2021)

Article Immunology

Cholera surveillance and estimation of burden of cholera

Divya Ganesan et al.

VACCINE (2020)

Article Immunology

Diagnostic techniques for rapid detection of Vibrio cholerae O1/O139

Thandavarayan Ramamurthy et al.

VACCINE (2020)

Article Multidisciplinary Sciences

Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae

Archana Pant et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Immunology

Virulence Regulation and Innate Host Response in the Pathogenicity ofVibrio cholerae

Thandavarayan Ramamurthy et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism

Francis J. Santoriello et al.

NATURE COMMUNICATIONS (2020)

Review Immunology

Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA

Kang Chen et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Regulated Proteolysis in Vibrio cholerae Allowing Rapid Adaptation t o Stress Conditions

Nina Pennetzdorfer et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Article Tropical Medicine

Safety and Immunogenicity of Live Oral Cholera Vaccine CVD 103-HgR in Children and Adolescents Aged 6–17 Years

James M. McCarty et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2019)

Article Public, Environmental & Occupational Health

Herd protection of unvaccinated adults by oral cholera vaccines in rural Bangladesh

Mohammad Ali et al.

INTERNATIONAL HEALTH (2019)

Article Immunology

Recurrent Cholera Outbreaks, Democratic Republic of the Congo, 2008-2017

Brecht Ingelbeen et al.

EMERGING INFECTIOUS DISEASES (2019)

Article Biochemistry & Molecular Biology

Vibrio cholerae OmpU induces IL-8 expression in human intestinal epithelial cells

Jae Seung Yang et al.

MOLECULAR IMMUNOLOGY (2018)

Article Genetics & Heredity

Defining endemic cholera at three levels of spatiotemporal resolution within Bangladesh

Daryl Domman et al.

NATURE GENETICS (2018)

Article Cell Biology

A live vaccine rapidly protects against cholera in an infant rabbit model

Troy P. Hubbard et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Review Pediatrics

Guidelines for the management of paediatric cholera infection: a systematic review of the evidence

Phoebe C. M. Williams et al.

PAEDIATRICS AND INTERNATIONAL CHILD HEALTH (2018)

Article Immunology

Cholera: Immunity and Prospects in Vaccine Development

Jason B. Harris

JOURNAL OF INFECTIOUS DISEASES (2018)

Article Immunology

Global Cholera Epidemiology: Opportunities to Reduce the Burden of Cholera by 2030

Dominique Legros

JOURNAL OF INFECTIOUS DISEASES (2018)

Review Microbiology

Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection

Diliana Perez-Reytor et al.

FRONTIERS IN MICROBIOLOGY (2018)

Article Immunology

PaxVax CVD 103-HgR single-dose live oral cholera vaccine

Myron M. Levine et al.

EXPERT REVIEW OF VACCINES (2017)

Review Medicine, General & Internal

Cholera

John D. Clemens et al.

LANCET (2017)

Article Multidisciplinary Sciences

Genomic history of the seventh pandemic of cholera in Africa

Francois-Xavier Weill et al.

SCIENCE (2017)

Review Immunology

Major findings and recent advances in virus like particle (VLP)-based vaccines

Mona O. Mohsen et al.

SEMINARS IN IMMUNOLOGY (2017)

Review Infectious Diseases

Vibrio cholerae Biofilms and Cholera Pathogenesis

Anisia J. Silva et al.

PLOS NEGLECTED TROPICAL DISEASES (2016)

Review Pharmacology & Pharmacy

Delivery strategies to enhance oral vaccination against enteric infections

Christopher J. H. Davitt et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

Review Biochemistry & Molecular Biology

Whole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1

Eun Jin Kim et al.

TRENDS IN MICROBIOLOGY (2015)

Review Biotechnology & Applied Microbiology

Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part I: Overview, vaccines for enteric viruses and Vibrio cholerae

Miguel O'Ryan et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2015)

Article Infectious Diseases

Bile Salts Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae

Verena Bachmann et al.

PLOS NEGLECTED TROPICAL DISEASES (2015)

Article Infectious Diseases

Updated Global Burden of Cholera in Endemic Countries

Mohammad Ali et al.

PLOS NEGLECTED TROPICAL DISEASES (2015)

Review Microbiology

Intestinal Colonization Dynamics of Vibrio cholerae

Salvador Almagro-Moreno et al.

PLOS PATHOGENS (2015)

Article Microbiology

A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles

Deborah R. Leitner et al.

Frontiers in Microbiology (2015)

Review Immunology

Novel Transgenic Rice-Based Vaccines

Tatsuhiko Azegami et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2015)

Article Pharmacology & Pharmacy

New Developments in Oral Vaccines and Mucosal Adjuvants

Jose L. Subiza et al.

RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY (2015)

Review Infectious Diseases

Dynamics in genome evolution of Vibrio cholerae

Rachana Banerjee et al.

INFECTION GENETICS AND EVOLUTION (2014)

Article Microbiology

The Type II Secretion System Delivers Matrix Proteins for Biofilm Formation by Vibrio cholerae

Tanya L. Johnson et al.

JOURNAL OF BACTERIOLOGY (2014)

Article Medicine, General & Internal

Second-Pandemic Strain of Vibrio cholerae from the Philadelphia Cholera Outbreak of 1849

Alison M. Devault et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Multidisciplinary Sciences

Proteomic analysis of Vibrio cholerae outer membrane vesicles

Emrah Altindis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Infectious Diseases

Evaluation in Mice of a Conjugate Vaccine for Cholera Made from Vibrio cholerae O1 (Ogawa) O-Specific Polysaccharide

Mohammad Murshid Alam et al.

PLOS NEGLECTED TROPICAL DISEASES (2014)

Review Immunology

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Lance W. Peterson et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Infectious Diseases

The incubation period of cholera: A systematic review

Andrew S. Azman et al.

JOURNAL OF INFECTION (2013)

Article Multidisciplinary Sciences

Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence

Menghua Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Immunology

Vibrio cholerae Non-O1, Non-O139 Serogroups and Cholera-like Diarrhea, Kolkata, India

Devarati Dutta et al.

EMERGING INFECTIOUS DISEASES (2013)

Review Microbiology

The type II secretion system: biogenesis, molecular architecture and mechanism

Konstantin V. Korotkov et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Article Immunology

TLP01, an mshA mutant of Vibrio cholerae O139 as vaccine candidate against cholera

Talena Ledon et al.

MICROBES AND INFECTION (2012)

Article Biochemistry & Molecular Biology

Accessory Cholera Enterotoxin, Ace, from Vibrio cholerae: Structure, Unfolding, and Virstatin Binding

Tanaya Chatterjee et al.

BIOCHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

Highly expressed cholera toxin B subunit in the fruit of a transgenic tomato (Lycopersicon esculentum L.)

Nguyen Hoang Loc et al.

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2011)

Article Biochemistry & Molecular Biology

Proteomic Analysis of the Vibrio cholerae Type II Secretome Reveals New Proteins, Including Three Related Serine Proteases

Aleksandra E. Sikora et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Evidence for several waves of global transmission in the seventh cholera pandemic

Ankur Mutreja et al.

NATURE (2011)

Review Immunology

Regional and mucosal memory T cells

Brian S. Sheridan et al.

NATURE IMMUNOLOGY (2011)

Review Plant Sciences

Two decades of plant-based candidate vaccines: a review of the chimeric protein approaches

Ruth Elena Soria-Guerra et al.

PLANT CELL REPORTS (2011)

Article Infectious Diseases

Meeting Cholera's Challenge to Haiti and the World: A Joint Statement on Cholera Prevention and Care

Paul Farmer et al.

PLOS NEGLECTED TROPICAL DISEASES (2011)

Review Immunology

IL-6: Regulator of Treg/Th17 balance

Akihiro Kimura et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

Review Immunology

Development of plant-based mucosal vaccines against widespread infectious diseases

Rurick K. Salyaev et al.

EXPERT REVIEW OF VACCINES (2010)

Article Multidisciplinary Sciences

Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine

Daisuke Tokuhara et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax

Sandip K. Datta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

The Vibrio cholerae type VI secretion system displays antimicrobial properties

Dana L. MacIntyre et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Structure, biological functions and applications of the AB5 toxins

Travis Beddoe et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Immunology

Antigen-Specific Memory B-Cell Responses to Vibrio cholerae O1 Infection in Bangladesh

Aaron M. Harris et al.

INFECTION AND IMMUNITY (2009)

Article Immunology

Memory T-Cell Responses to Vibrio cholerae O1 Infection

Ana A. Weil et al.

INFECTION AND IMMUNITY (2009)

Article Immunology

Cholera Caused by Vibrio cholerae O1 Induces T-Cell Responses in the Circulation

Taufiqur Rahman Bhuiyan et al.

INFECTION AND IMMUNITY (2009)

Article Immunology

Bicarbonate Induces Vibrio cholerae Virulence Gene Expression by Enhancing ToxT Activity

Basel H. Abuaita et al.

INFECTION AND IMMUNITY (2009)

Article Microbiology

The Vibrio cholerae Flagellar Regulatory Hierarchy Controls Expression of Virulence Factors

Khalid Ali Syed et al.

JOURNAL OF BACTERIOLOGY (2009)

Review Microbiology

Cholera transmission: the host, pathogen and bacteriophage dynamic

Eric J. Nelson et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Multidisciplinary Sciences

Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae

Jongsik Chun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Gastroenterology & Hepatology

Early activation of mucosal dendritic cells and macrophages in acute Campylobacter colitis and cholera:: An in vivo study

Anna B. Pulimood et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2008)

Article Biochemistry & Molecular Biology

Expression of Cholera Toxin B Subunit in Transgenic Rice Endosperm

Maria Oszvald et al.

MOLECULAR BIOTECHNOLOGY (2008)

Article Multidisciplinary Sciences

Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination

Tomonori Nochi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Microbiology

Regulation of virulence in Vibrio cholerae:: the ToxR regulon

Brandon M. Childers et al.

FUTURE MICROBIOLOGY (2007)

Article Immunology

Broad up-regulation of innate defense factors during acute cholera

Carl-Fredrik Flach et al.

INFECTION AND IMMUNITY (2007)

Article Biochemistry & Molecular Biology

Human intestinal epithelial cell cytokine mRNA responses mediated by NF-κB are modulated by the motility and adhesion process of vibrio cholerae

Arunava Bandyopadhaya et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Vibrio cholerae: Cholera toxin

Davy Vanden Broeck et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Microbiology

Cholera due to altered El Tor Strains of Vibrio cholerae O1 in Bangladesh

G. Balakrish Nair et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2006)

Article Microbiology

RpoS controls the Vibrio cholerae mucosal escape response

Alex Toftgaard Nielsen et al.

PLOS PATHOGENS (2006)

Article Biochemistry & Molecular Biology

Deoxycholic acid blocks Vibrio cholerae OmpT but not OmpU porin

Guillaume Duret et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Cholera stool bacteria repress chemotaxis to increase infectivity

SM Butler et al.

MOLECULAR MICROBIOLOGY (2006)

Article Critical Care Medicine

Interleukin-8

DG Remick

CRITICAL CARE MEDICINE (2005)

Review Microbiology

Going against the grain:: Chemotaxis and infection in Vibrio cholerae

SM Butler et al.

NATURE REVIEWS MICROBIOLOGY (2005)

Article Medicine, General & Internal

Effectiveness of mass oral cholera vaccination in Beira, Mozambique

MES Lucas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Multidisciplinary Sciences

Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner

DT Hung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Microbiology

Vibrios commonly possess two chromosomes

K Okada et al.

JOURNAL OF BACTERIOLOGY (2005)

Article Multidisciplinary Sciences

Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae

SM Butler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area

SM Faruque et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Medicine, General & Internal

Cholera

DA Sack et al.

LANCET (2004)

Article Biochemistry & Molecular Biology

Sialic acid recognition by Vibrio cholerae neuraminidase

I Moustafa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

The Vibrio cholerae Porins OmpU and OmpT have distinct channel properties

VC Simonet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemical Research Methods

Expression of cholera toxin B subunit in transgenic tomato plants

D Jani et al.

TRANSGENIC RESEARCH (2002)

Article Multidisciplinary Sciences

Host-induced epidemic spread of the cholera bacterium

DS Merrell et al.

NATURE (2002)

Article Multidisciplinary Sciences

Quorum-sensing regulators control virulence gene expression in Vibrio cholerae

J Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Immunology

Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139

F Qadri et al.

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2002)

Article Biochemistry & Molecular Biology

Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae

DS Merrell et al.

MOLECULAR MICROBIOLOGY (2002)

Article Microbiology

The ToxR-mediated organic acid tolerance response of Vibrio cholerae requires OmpU

DS Merrell et al.

JOURNAL OF BACTERIOLOGY (2001)

Article Medicine, Research & Experimental

Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6

SV Sitaraman et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Multidisciplinary Sciences

DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae

JF Heidelberg et al.

NATURE (2000)

Article Immunology

Cell vacuolation, a manifestation of the El Tor hemolysin of Vibrio cholerae

R Mitra et al.

INFECTION AND IMMUNITY (2000)

Article Immunology

Cytotoxic cell vacuolating activity from Vibrio cholerae hemolysin

A Coelho et al.

INFECTION AND IMMUNITY (2000)