Shenkang injection combined with alprostadil for chronic renal failure: A systematic review and meta-analysis

Article Pharmacology & Pharmacy

Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation

Satoyasu Ito et al.

Summary: The study suggests that Juzentaihoto (TJ-48) may exert a renal protective effect in mice with adenine-induced chronic kidney disease by suppressing fibrosis and inflammation.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Review Pharmacology & Pharmacy

Comparative effectiveness of traditional Chinese medicine and angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and sodium glucose cotransporter inhibitors in patients with diabetic kidney disease: A systematic review and network meta-analysis

Lili Zhang et al.

Summary: Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, sodium glucose cotransporter inhibitors, and traditional Chinese medicine have all shown significant efficacy in the treatment of diabetic kidney disease, with the combination of traditional Chinese medicine and angiotensin converting enzyme inhibitors being the most effective option.

PHARMACOLOGICAL RESEARCH (2022)

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Article Plant Sciences

Shenkang injection protects against renal fibrosis by reducing perforin expression through the STING/TBK1/IRF3 signaling pathways in natural killer cells

Junfeng Hao et al.

Summary: This study investigated the mechanisms by which Shenkang injection (SKI) alleviates renal interstitial fibrosis (RIF) in chronic kidney disease (CKD). The results showed that SKI reduced renal fibrosis in an in vivo CKD model and downregulated the activity of natural killer (NK) cells. Additionally, SKI was found to regulate the activity of the STING/TBK1/IRF3 signaling pathway.

PHYTOMEDICINE (2022)

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Article Medicine, General & Internal

Chronic Renal Failure and Cardiovascular Disease: A Comprehensive Appraisal

Keren Skalsky et al.

Summary: Coronary artery disease is prevalent in patients with chronic kidney disease, and there are challenges in diagnosing, treating and preventing this disease in this population.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Integrative & Complementary Medicine

ShenKang Injection Attenuates Renal Fibrosis by Inhibiting EMT and Regulating the Wnt/β-Catenin Pathway

Hui-Ting Wei et al.

Summary: Shenkang Injection (SKI), a traditional Chinese medicine injection, has been found to have anti-fibrotic effects in the treatment of chronic kidney disease. The study suggests that SKI may inhibit renal fibrosis by regulating the Wnt/beta-catenin pathway and inhibiting epithelial-mesenchymal transition (EMT). The results show that SKI reduces morphological changes and collagen deposition associated with renal fibrosis, and improves kidney function by lowering blood urea nitrogen and serum creatinine levels.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Integrative & Complementary Medicine

Effects of Shenkang Injection Combined with Jinshuibao on Early Diabetic Nephropathy and Effects on Coagulation Fibrinolysis System and Urinary Protein

Jianhua Zhu et al.

Summary: The combination of Shenkang injection (SKI) and Jinshuibao has a significant therapeutic effect on early diabetic nephropathy (DN). This combined treatment can reduce the risk of hyperfunction of the coagulation fibrinolysis system, decrease urine protein content, and delay the progression of DN.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Peir-Haur Hung et al.

Summary: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease, characterized by glomerular hyperfiltration, progressive albuminuria, and declining estimated glomerular filtration rate leading to kidney failure. Metabolic changes and programmed epigenetic modifications resulting from hyperglycemia are believed to play a role in the development of DKD, although the detailed mechanisms are still not fully understood.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Efficacy and safety of Shenkang injection in the treatment of chronic renal failure A protocol of a randomized controlled trial

JuXiang Mei et al.

Summary: This study focuses on exploring the efficacy and safety of Shenkang injection for chronic renal failure (CRF) through a prospective randomized controlled trial, evaluating various indicators to assess its effects. The results of the study are expected to provide important guidance and evidence for clinical practice.

MEDICINE (2021)

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Review Medicine, General & Internal

Efficacy and safety of colonic dialysis combined with traditional Chinese medicine retention enema in the treatment of chronic renal failure A protocol for systematic review and meta-analysis

Zhilei Wang et al.

Summary: Chronic renal failure is a major global public health issue, and colonic dialysis combined with Traditional Chinese medicine retention enema has shown good effectiveness and safety in treating chronic renal failure, delaying the progression of kidney disease.

MEDICINE (2021)

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Review Medicine, General & Internal

Reduction of protein-bound uraemic toxins in plasma of chronic renal failure patients: A systematic review

V. Saar-Kovrov et al.

Summary: This systematic review found that there is currently no technique universally suitable for optimum reduction of all protein-bound uraemic toxins (PBUTs). Further research is needed in this field to identify more effective methods for reducing PBUTs in patients with chronic kidney disease.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems