4.6 Review

All tangled up: interactions of the fibrinolytic and innate immune systems

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

ProCPU Is Expressed by (Primary) Human Monocytes and Macrophages and Expression Differs between States of Differentiation and Activation

Karen Claesen et al.

Summary: Carboxypeptidase U (CPU) is synthesized in the liver as its inactive precursor proCPU and acts as a regulator of fibrinolysis and inflammation. Monocytes and macrophages, which play a central role in inflammation and thrombus formation, were found to express proCPU and secrete CPU. The expression and secretion of proCPU in these cells are related to their differentiation degree.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Review Pathology

Association of PAI-1 4G/5G and ACE I/D Polymorphisms with Susceptibility to Pediatric Sepsis: Evidence from a Meta-Analysis

Mohammad Hosein Jarahzadeh et al.

Summary: A meta-analysis suggests that the PAI-1 4G/5G and ACE I/D polymorphisms may be risk factors for the development of pediatric sepsis in the global population, particularly in Caucasian children.

FETAL AND PEDIATRIC PATHOLOGY (2022)

Article Hematology

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles

Laura Somodi et al.

Summary: Receptor-mediated activation can expose cFXIII on the surface of more than 60% of platelets, while non-receptor mediated activation failed to do so, indicating that the translocation of cFXIII requires additional receptor-mediated mechanisms.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

Article Critical Care Medicine

Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19 A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial

Christopher D. Barrett et al.

Summary: This study investigated the effects of tissue plasminogen activator (tPA) on pulmonary function in severe COVID-19 respiratory failure. The results showed significant improvement in lung oxygenation in the tPA bolus group compared to the control group. However, there were no statistically significant differences in the improvement of PaO2/FIO2 ratio, composite outcome, ventilator-free days, and in-hospital mortality between the tPA bolus group and the control group.
Article Hematology

The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1

Claire S. Whyte et al.

Summary: This study investigates the dysregulation of the fibrinolytic system in COVID-19 disease and finds that elevated levels of PAI-1 suppress plasmin generation, leading to suboptimal fibrinolysis. These findings have important implications for the treatment and prognostic potential of COVID-19 disease.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

Article Hematology

uPA-mediated plasminogen activation is enhanced by polyphosphate

Claire S. Whyte et al.

Summary: The study shows that polyP has opposite effects on tPA- and uPA-mediated fibrinolysis, attenuating the fibrin cofactor function in tPA-mediated plasminogen activation while facilitating the interaction between fibrin-independent uPA and plasminogen to accelerate downstream fibrinolysis.

HAEMATOLOGICA (2021)

Article Hematology

Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets

Claire S. Whyte et al.

Summary: Plasminogen activation rates are enhanced by cell surface binding, with lysine-dependent mechanisms playing a key role in platelet-derived plasminogen retention and activation on activated platelet membranes. Plg-R-KT has been identified as a novel plasminogen receptor in human and murine platelets, colocalizing with platelet-derived plasminogen on the activated platelet membrane to drive local fibrinolysis.
Review Cell Biology

Immunothrombosis and thromboinflammation in host defense and disease

Kimberly Martinod et al.

Summary: Platelets play roles beyond thrombosis and hemostasis by mediating inflammation through direct interactions with immune cells and secretion of cytokines/chemokines. They interact with neutrophils and monocytes/macrophages in infections, sepsis, stroke, myocardial infarctions, and venous thromboembolisms, while also contributing to the formation of neutrophil extracellular traps (NETs) and deep vein thrombosis during infections like in COVID-19 patients.

PLATELETS (2021)

Article Biochemistry & Molecular Biology

Role of Shear Stress and tPA Concentration in the Fibrinolytic Potential of Thrombi

Claire S. Whyte et al.

Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Plasminogen Receptors and Fibrinolysis

Lindsey A. Miles et al.

Summary: The role of plasminogen receptors on cell surfaces in promoting fibrinolysis is well recognized, with these receptors shown to regulate fibrin surveillance in addition to plasminogen directly bound to fibrin. Data from murine models predominantly demonstrate the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in vivo. The roles of distinct plasminogen receptors in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Fibrinolysis: A Primordial System Linked to the Immune Response

Robert L. Medcalf et al.

Summary: The fibrinolytic system, led by the protease plasmin, plays a crucial role in removing fibrin deposits and blood clots, as well as modulating immune cell behavior and pathogen defense mechanisms. Phylogenetic studies suggest that plasmin may have originated as an immune-modifying protease before evolving to its fibrin-removing capacity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Hematology

Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID-19: A single-center prospective longitudinal study

Ganeem K. Juneja et al.

Summary: Immunothrombosis and coagulopathy in the lung microvasculature may lead to lung injury and disease progression in COVID-19. Biomarkers such as elevated D-dimer were associated with disease severity, while clot lysis time, sTM, PAI-1, and plasminogen levels may have predictive ability for mortality.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Review Cardiac & Cardiovascular Systems

Interplay between inflammation and thrombosis in cardiovascular pathology

Konstantin Stark et al.

Summary: Thrombosis is a major health challenge globally, with inflammation playing a crucial role in driving thrombotic diseases. Anti-inflammatory strategies show promise in targeting cardiovascular pathologies and addressing therapeutic gaps.

NATURE REVIEWS CARDIOLOGY (2021)

Review Cardiac & Cardiovascular Systems

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

Gael B. Morrow et al.

Summary: PAI-1 plays a crucial role in maintaining hemostatic balance and is associated with cardiovascular diseases, inflammation, and metabolic syndrome.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation

Fahad S. M. Alshehri et al.

Summary: FXIII is a transglutaminase that promotes thrombus stability by cross-linking fibrin. Monocytes and THP-1 cells exhibit up-regulation of FXIII-A antigen and activity in response to IL-4 and IL-10 stimulation, leading to enhanced stability of thrombi against fibrinolytic degradation. Membrane-associated FXIII-A in monocytes appears to play a crucial role in thrombus stabilization, particularly through a transglutaminase-dependent mechanism.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Aldo Bonaventura et al.

Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Medicine, General & Internal

Post-Traumatic Sepsis Is Associated with Increased C5a and Decreased TAFI Levels

Jan Tilmann Vollrath et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Multidisciplinary Sciences

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

Sujin Kang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Immunology

TLR4 Response to LPS Is Reinforced by Urokinase Receptor

Yulia Kiyan et al.

FRONTIERS IN IMMUNOLOGY (2020)

Meeting Abstract Hematology

The Role of Plasmin/Plasminogen in Experimental Polymicrobial Sepsis

Juliana Vago et al.

Review Immunology

Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

Nonantzin Beristain-Covarrubias et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Medicine, Research & Experimental

A fibrin biofilm covers blood clots and protects from microbial invasion

Fraser L. Macrae et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Hematology

Regulation of plasminogen activation on cell surfaces and fibrin

T. Urano et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Review Cell Biology

The Role of Macrophages in the Pathogenesis of ALI/ARDS

Xiaofang Huang et al.

MEDIATORS OF INFLAMMATION (2018)

Review Biochemistry & Molecular Biology

Plasminogen-binding proteins as an evasion mechanism of the host's innate immunity in infectious diseases

Dolores A. Ayon-Nunez et al.

BIOSCIENCE REPORTS (2018)

Article Cell Biology

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Yuping Yuan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Clinical Neurology

Neutrophil Extracellular Traps in Ischemic Stroke Thrombi

Elodie Laridan et al.

ANNALS OF NEUROLOGY (2017)

Review Microbiology

Bacterial pathogens activate plasminogen to breach tissue barriers and escape from innate immunity

Marijke Peetermans et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2016)

Review Hematology

Structure-function relationships in thrombin-activatable fibrinolysis inhibitor

T. Plug et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2016)

Article Multidisciplinary Sciences

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response

Elisabetta Mantuano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Platelets Guide Leukocytes to Their Sites of Extravasation

Gabriele Zuchtriegel et al.

PLOS BIOLOGY (2016)

Article Hematology

Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis

Travis J. Gould et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

Meike Dittmann et al.

Article Hematology

Coagulation in Patients with Severe Sepsis

Marcel Levi et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2015)

Article Multidisciplinary Sciences

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin

Rachael J. Borg et al.

PLOS ONE (2015)

Article Hematology

Plasminogen promotes macrophage phagocytosis in mice

Riku Das et al.

Article Hematology

Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice

S. A. Siefert et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2014)

Article Hematology

Single-chain factor XII exhibits activity when complexed to polyphosphate

R. Engel et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2014)

Article Multidisciplinary Sciences

Neutrophils scan for activated platelets to initiate inflammation

Vinatha Sreeramkumar et al.

SCIENCE (2014)

Article Biochemistry & Molecular Biology

Thrombin-Activatable Fibrinolysis Inhibitor Protects against Acute Lung Injury by Inhibiting the Complement System

Masahiro Naito et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones

Colin Longstaff et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Hematology

Plasminogen Receptors: The First Quarter Century

Lindsey A. Miles et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2013)

Review Immunology

Thrombosis as an intravascular effector of innate immunity

Bernd Engelmann et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Biotechnology & Applied Microbiology

So Many Plasminogen Receptors: Why?

Edward F. Plow et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Review Biotechnology & Applied Microbiology

Bacterial Plasminogen Receptors: Mediators of a Multifaceted Relationship

Martina L. Sanderson-Smith et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Review Biotechnology & Applied Microbiology

Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination

Sarbani Bhattacharya et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Article Immunology

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

Marie-Luise von Bruehl et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Article Biochemistry & Molecular Biology

Critical role of type 1 plasminogen activator inhibitor (PAI-1) in early host defense against nontypeable Haemophilus influenzae (NTHi) infection

Jae Hyang Lim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Cardiac & Cardiovascular Systems

Platelet Protease Nexin-1, a Serpin That Strongly Influences Fibrinolysis and Thrombolysis

Yacine Boulaftali et al.

CIRCULATION (2011)

Article Biochemistry & Molecular Biology

Contribution of Conserved Lysine Residues in the α2-Antiplasmin C Terminus to Plasmin Binding and Inhibition

Bernadine G. C. Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Medicine, Research & Experimental

Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis

Jason J. Song et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Hematology

Secretion and antifibrinolytic function of thrombin-activatable fibrinolysis inhibitor from human platelets

S. L. Schadinger et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)

Article Biochemistry & Molecular Biology

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Steffen Massberg et al.

NATURE MEDICINE (2010)

Article Biochemistry & Molecular Biology

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

Felicitas Muller et al.

Article Urology & Nephrology

Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis

Joris J. T. H. Roelofs et al.

KIDNEY INTERNATIONAL (2009)

Review Physiology

The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability

Sreerama Shetty et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

Article Hematology

Fibrin and fibrinolysis in infection and host defense

J. L. Degen et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)

Article Surgery

A brief overview of acute respiratory distress syndrome

Robert M. Hardaway

WORLD JOURNAL OF SURGERY (2006)

Review Critical Care Medicine

Pathophysiology of acute lung injury and the acute respiratory distress syndrome

Lorraine B. Ware

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Article Multidisciplinary Sciences

Polyphosphate modulates blood coagulation and fibrinolysis

SA Smith et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Neutrophil extracellular traps kill bacteria

V Brinkmann et al.

SCIENCE (2004)

Article Medicine, General & Internal

Risk of myocardial infarction and stroke after acute infection or vaccination

L Smeeth et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Physiology

Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury

P Prabhakaran et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)

Article Biochemistry & Molecular Biology

Candida albicans binds human plasminogen:: identification of eight plasminogen-binding proteins

JD Crowe et al.

MOLECULAR MICROBIOLOGY (2003)

Article Parasitology

Interaction of different Leishmania mexicana morphotypes with plasminogen

M Calcagno et al.

PARASITOLOGY RESEARCH (2002)

Article Immunology

Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N

WD Campbell et al.

MICROBIOLOGY AND IMMUNOLOGY (2002)

Review Medicine, General & Internal

Medical progress - The acute respiratory distress syndrome.

LB Ware et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

Article Critical Care Medicine

Coagulation system and platelets are fully activated in uncomplicated sepsis

AC Mavrommatis et al.

CRITICAL CARE MEDICINE (2000)