☆ 4.6 Review

Hepatic Mitochondria-Gut Microbiota Interactions in Metabolism-Associated Fatty Liver Disease

METABOLITES (2023)

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Summary: Mitochondrial dysfunction is central to the pathobiology of NAFLD, making maintenance of mitochondrial homeostasis crucial for treatment. Mitophagy, a process of selectively clearing damaged mitochondria through autophagy, promotes mitochondrial homeostasis. Strategies regulating mitophagy have shown promise in preclinical experiments. Traditional Chinese medicine, a natural product with active ingredients, has great potential in liver disease prevention and treatment. This review summarizes mitophagy-related pathways and the latest findings on mitophagy regulation in NAFLD, highlighting the potential of Traditional Chinese medicine.

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Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

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Summary: This study provides evidence for the relevance of the interaction between mitochondria and microbiota in NASH and identifies targeting this interaction as a valuable therapeutic approach.

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Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine

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Altered Mitochondrial Quality Control in Rats with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Induced by High-Fat Feeding

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Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives

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CREBH alleviates mitochondrial oxidative stress through SIRT3 mediating deacetylation of MnSOD and suppression of Nlrp3 inflammasome in NASH

Junli Zhang et al.

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Bernard Fromenty et al.

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Xingxing Li et al.

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Article Biochemistry & Molecular Biology

Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease

Liang Guo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Review Food Science & Technology

Mitochondria-Mediated Pathogenesis and Therapeutics for Non-Alcoholic Fatty Liver Disease

Zheng Li et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Host mitochondria influence gut microbiome diversity: A role for ROS

Tal Yardeni et al.

SCIENCE SIGNALING (2019)

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Article Biochemistry & Molecular Biology

Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner

Xin Han et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

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Review Nutrition & Dietetics

Relationship between Changes in Microbiota and Liver Steatosis Induced by High-Fat Feeding-A Review of Rodent Models

Saioa Gomez-Zorita et al.

NUTRIENTS (2019)

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Article Biochemistry & Molecular Biology

Syntaxin-17-Dependent Mitochondrial Dynamics Is Essential for Protection against Oxidative-Stress-Induced Apoptosis

Binran Wang et al.

ANTIOXIDANTS (2019)

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Article Nutrition & Dietetics

A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

Saeed Chashmniam et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2019)

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Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease - A global public health perspective

Zobair M. Younossi

JOURNAL OF HEPATOLOGY (2019)

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Review Endocrinology & Metabolism

NAFLD and Atherosclerosis: Two Sides of the Same Dysmetabolic Coin?

Daniela Stols-Goncalves et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

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Review Endocrinology & Metabolism

Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease

Ze Chen et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

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Review Microbiology

What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases

Emanuele Rinninella et al.

MICROORGANISMS (2019)

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Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Review Gastroenterology & Hepatology

Lipotoxicity and the gut-liver axis in NASH pathogenesis

Fabio Marra et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Food Science & Technology

Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin

Peiyi Liu et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

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Article Cell Biology

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

Smitha Krishnan et al.

CELL REPORTS (2018)

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Article Pharmacology & Pharmacy

4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

Hongqiong Zhao et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

Francesco Bellanti et al.

REDOX BIOLOGY (2018)

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Article Endocrinology & Metabolism

Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice

Yongning Sun et al.

NUTRITION & DIABETES (2018)

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Review Biochemistry & Molecular Biology

Study of the Serum Metabolomic Profile in Nonalcoholic Fatty Liver Disease: Research and Clinical Perspectives

Stefano Gitto et al.

METABOLITES (2018)

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Review Gastroenterology & Hepatology

Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases

Abdellah Mansouri et al.

GASTROENTEROLOGY (2018)

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Article Biochemistry & Molecular Biology

Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression

Da Zhou et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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Letter Gastroenterology & Hepatology

Liver Fat Accumulation as a Barometer of Insulin Responsiveness Again Points to Adipose Tissue as the Culprit

Fernando Bril et al.

HEPATOLOGY (2017)

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Review Gastroenterology & Hepatology

Lipid droplets and liver disease: from basic biology to clinical implications

Nina L. Gluchowski et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Nutrition & Dietetics

Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis

Chien-Chao Chiu et al.

NUTRIENTS (2017)

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Review Physiology

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise

Allison Clark et al.

FRONTIERS IN PHYSIOLOGY (2017)

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Article Microbiology

The Microbiome-Mitochondrion Connection: Common Ancestries, Common Mechanisms, Common Goals

Alfredo Franco-Obregon et al.

MSYSTEMS (2017)

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Article Multidisciplinary Sciences

Mitochondria-targeted antioxidants as highly effective antibiotics

Pavel A. Nazarov et al.

SCIENTIFIC REPORTS (2017)

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Article Microbiology

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation

Marta Wlodarska et al.

CELL HOST & MICROBE (2017)

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Article Nutrition & Dietetics

Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related factor-2 signaling pathway

Sang Mi Park et al.

EUROPEAN JOURNAL OF NUTRITION (2016)

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Review Gastroenterology & Hepatology

REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Julio Madrigal-Matute et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

The Severity of Nonalcoholic Fatty Liver Disease Is Associated With Gut Dysbiosis and Shift in the Metabolic Function of the Gut Microbiota

Jerome Boursier et al.

HEPATOLOGY (2016)

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Article Oncology

Mitochondrial genome architecture in non-alcoholic fatty liver disease

Silvia Sookoian et al.

JOURNAL OF PATHOLOGY (2016)

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Article Multidisciplinary Sciences

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

Jung-ha Park et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

Max Gulhane et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

Yuanyuan Lu et al.

SCIENTIFIC REPORTS (2016)

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Article Nutrition & Dietetics

Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)

Cheng Jun Jin et al.

BRITISH JOURNAL OF NUTRITION (2015)

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Article Cell Biology

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

Chrysi Koliaki et al.

CELL METABOLISM (2015)

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Review Endocrinology & Metabolism

Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk

E. Angela Murphy et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2015)

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Article Cell Biology

How informative is the mouse for human gut microbiota research?

Thi Loan Anh Nguyen et al.

DISEASE MODELS & MECHANISMS (2015)

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Article Gastroenterology & Hepatology

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Edward S. Chambers et al.

GUT (2015)

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Article Pathology

Targeting Mitochondria-Derived Reactive Oxygen Species to Reduce Epithelial Barrier Dysfunction and Colitis

Arthur Wang et al.

AMERICAN JOURNAL OF PATHOLOGY (2014)

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Article Gastroenterology & Hepatology

Association of germ-free mice with a simplified human intestinal microbiota results in a shortened intestine

Kathleen Slezak et al.

GUT MICROBES (2014)

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Article Biochemistry & Molecular Biology

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

Sara Cogliati et al.

CELL (2013)

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Review Biochemistry & Molecular Biology

The pathways of mitophagy for quality control and clearance of mitochondria

G. Ashrafi et al.

CELL DEATH AND DIFFERENTIATION (2013)

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Article Gastroenterology & Hepatology

Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect

R. Scott Rector et al.

HEPATOLOGY (2013)

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Review Biochemistry & Molecular Biology

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

Gijs den Besten et al.

JOURNAL OF LIPID RESEARCH (2013)

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Review Cardiac & Cardiovascular Systems

The connection between inner membrane topology and mitochondrial function

Carmen A. Mannella et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)

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Review Biochemistry & Molecular Biology

The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

Fatma Ucar et al.

REDOX REPORT (2013)

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Article Cell Biology

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

Sameer Kalghatgi et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast

Yusuke Kurihara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Multidisciplinary Sciences

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Jorge Henao-Mejia et al.

NATURE (2012)

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Article Medicine, Research & Experimental

Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice

Michal Aharoni-Simon et al.

LABORATORY INVESTIGATION (2011)

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Article Multidisciplinary Sciences

Oxidation of Hepatic Carnitine Palmitoyl Transferase-I (CPT-I) Impairs Fatty Acid Beta-Oxidation in Rats Fed a Methionine-Choline Deficient Diet

Gaetano Serviddio et al.

PLOS ONE (2011)

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Review Gastroenterology & Hepatology

Mitochondrial dysfunction in nonalcoholic steatohepatitis

Gaetano Serviddio et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2011)

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Article Pathology

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

Anne M. Cataldo et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Article Biochemistry & Molecular Biology

Pyruvate kinase in pig liver mitochondria

Roberto Pizzuto et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

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Article Cell Biology

Long-term High-fat-diet Feeding Impairs Mitochondrial Biogenesis in Liver of Male and Female Rats

Antonia Nadal-Casellas et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2010)

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Review Biochemistry & Molecular Biology

OXPHOS gene express ion and control in mitochondrial disorders

Fimmie Reinecke et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

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Article Medicine, General & Internal

Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model

G. Serviddio et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2008)

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Article Gastroenterology & Hepatology

Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury

G. Serviddio et al.

GUT (2008)

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Review Biochemistry & Molecular Biology

Mitochondrial involvement in non-alcoholic steatohepatitis

Gaetano Serviddio et al.

MOLECULAR ASPECTS OF MEDICINE (2008)

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Article Gastroenterology & Hepatology

Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance

JA Ibdah et al.

GASTROENTEROLOGY (2005)

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Review Biochemistry & Molecular Biology

Control of mitochondrial β-oxidation flux

S Eaton

PROGRESS IN LIPID RESEARCH (2002)

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Review Biochemistry & Molecular Biology

The internal structure of mitochondria

TG Frey et al.

TRENDS IN BIOCHEMICAL SCIENCES (2000)

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