期刊
METABOLITES
卷 13, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/metabo13040501
关键词
black cumin; metabolic disorder; NAFLD; obese diabetic mice; type 2 diabetes
In order to address the negative effects of current treatments for metabolic disorders, researchers investigated the therapeutic potential of black cumin seeds extract for type 2 diabetes using a mouse model. The extract showed a dose-dependent improvement in obesity, fatty liver disease, hyperlipidemia, and diabetic nephropathy. It also demonstrated antioxidant and anti-inflammatory properties, and improved glucose and fat metabolism. This study suggests that black cumin extract could be a promising alternative treatment option for metabolic disorders.
To deal with the adverse effects associated with the use of currently available treatments for metabolic disorders, such as type 2 diabetes, there is a need to find an alternative drug compound. In the present study, we investigated the therapeutic potential of black cumin (Nigella sativa L.) seeds extract (BCS extract) for type 2 diabetes using a 45% Kcal-fed obese mouse model. The BCS extract at different doses (400-100 mg/kg) showed a dose-dependent improvement tendency in high-fat diet (HFD)-induced obesity, non-alcoholic fatty liver disease (NAFLD), hyperlipidemia, and diabetic nephropathy compared to the metformin (250 mg/kg). In particular, BCS extract at a dose of 200 mg/kg significantly inhibited the HFD-induced metabolic conditions. The oral administration of BCS extract (200 mg/kg) significantly inhibited the oxidative stress through lipid peroxidation, normalized the activity of sugar metabolism-related enzymes and the expression of genes involved in fat metabolism, and inhibited insulin resistance through glucose and fat metabolism by regulating the 5'-AMP-activated protein kinase (AMPK) expression. Furthermore, BCS extract (200 mg/kg) showed renal damage improvement effects compared to the metformin (250 mg/kg). The results clearly show that BCS aqueous extract at an appropriate concentration could help in the treatment of metabolic disorders, and BCS aqueous extract can be used as a functional food for various diabetic complications, such as obesity, diabetes, and NAFLD.
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