☆ 4.6 Article

High-Intensity Interval Training Induces Protein Lactylation in Different Tissues of Mice with Specificity and Time Dependence

METABOLITES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats

Yuan Yao et al.

Summary: This study combined 4D label-free quantitative proteomics with lactylation modification-specific proteomics analysis to evaluate lysine lactylation in cortical proteins of a CIRI rat model. The results provide new insights into the lactylation mechanism of CIRI, affecting the mitochondrial apoptosis pathway and mediating neuronal death. The study has theoretical significance and broad clinical application prospects for developing therapeutic molecules.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2023)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Lipogenesis inhibitors: therapeutic opportunities and challenges

Battsetseg Batchuluun et al.

Summary: Fatty acids play essential roles in cellular survival and function as bioenergetic substrates, structural components, and signaling molecules. Cells have evolved de novo lipogenesis (DNL) to generate fatty acids from alternative carbon sources. However, abnormal upregulation of DNL is associated with various pathologies. Inhibiting core enzymes of DNL represents a potential therapeutic strategy, and several synthetic DNL inhibitors are currently in development. Aberrant upregulation of DNL is implicated in conditions such as cardiovascular disease, metabolic disorders, and cancers.

NATURE REVIEWS DRUG DISCOVERY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

Carlos Moreno-Yruela et al.

Summary: Lysine L-lactylation is a newly discovered histone modification that is stimulated under conditions of high glycolysis. Through systematic evaluation of histone deacetylases (HDACs), HDAC1-3 and SIRT1-3 were identified as delactylases for this modification. This study provides important insights into the regulatory mechanisms of histone lactylation.

SCIENCE ADVANCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

Kun Yang et al.

Summary: High levels of lactate and HMGB1 are associated with the severity and mortality of sepsis. Lactate can promote HMGB1 lactylation and acetylation in macrophages, leading to HMGB1 release and increased endothelium permeability. Targeting lactate-associated signaling pathways may offer a potential strategy to combat sepsis.

CELL DEATH AND DIFFERENTIATION (2022)

添加到收藏夹

Article Cell Biology

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease

Rui-Yuan Pan et al.

Summary: The dysregulation of microglial function in Alzheimer's disease is associated with the glycolysis/H4K12la/PKM2 positive feedback loop. Inhibiting this loop can ameliorate pathological changes and cognitive deficits in a mouse model. This suggests that disrupting the positive feedback loop may be a potential therapeutic approach for treating AD.

CELL METABOLISM (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Jia Xiong et al.

Summary: The lactylation-driven METTL3-mediated RNA m(6)A modification plays an important role in promoting the immunosuppressive capacity of tumor-infiltrating myeloid cells (TIMs).

MOLECULAR CELL (2022)

添加到收藏夹

Review Geriatrics & Gerontology

High Intensity Interval Training: A Potential Method for

Qian-Qi Liu et al.

Summary: Sarcopenia, an age-related disease, has severe impacts on the aging population. Traditional persistent aerobic exercise is being replaced by high intensity interval training (HIIT), which has shown similar or even better effects in improving muscle strength, physical performance, and muscle mass in older individuals. However, there is a lack of direct research on the effects of HIIT on sarcopenia patients.

CLINICAL INTERVENTIONS IN AGING (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Lactate increases stemness of CD8+T cells to augment anti-tumor immunity

Qiang Feng et al.

Summary: Lactate increases stemness of CD8(+) T cells and enhances anti-tumor immunity. It inhibits histone deacetylase activity, leading to increased expression of Tcf7 gene, and affects the stemness of T cells.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney

Souad Nasser et al.

Summary: The ketogenic diet can alleviate symptoms of osteoarthritis by promoting weight loss, improving glycemic control, and modulating gene expression and histone post-translational modifications in the liver and kidney.

MOLECULAR METABOLISM (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

THE ROLE OF OXIDATIVE STRESS IN THE DEVELOPMENT OF OBESITY AND OBESITY-RELATED METABOLIC DISORDERS

Emina Colak et al.

Summary: Obesity is defined as excessive accumulation of fat and is associated with diseases such as hypertension and diabetes. Oxidative stress may play a key role in the development of obesity and related complications.

JOURNAL OF MEDICAL BIOCHEMISTRY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis

Li Gu et al.

Summary: This study identified an essential and wide-spread role of the IKK β-USP30-ACLY axis in tumor metabolism, which may be a potential therapeutic target in HCC.

HEPATOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation

Huachun Cui et al.

Summary: This study demonstrates that in lung fibrosis, myofibroblasts enhance glycolysis to produce lactate, which regulates the pathogenic phenotype of alveolar macrophages. Lactate induces profibrotic gene expression in macrophages, promoting the fibrotic process.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

添加到收藏夹

Review Cell Biology

NAD+ metabolism and its roles in cellular processes during ageing

Anthony J. Covarrubias et al.

Summary: NAD(+) is a crucial coenzyme in redox reactions and plays a pivotal role in energy metabolism. Its levels decline with age, and raising NAD(+) levels is being explored as a potential strategy to extend human lifespan and healthspan. NAD(+) influences key cellular processes and functions, including metabolic pathways, DNA repair, and cellular senescence, with implications for healthy aging and age-related diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness

Wang-Jing Mu et al.

Summary: Adipose tissue is crucial in metabolism, with excessive expansion leading to obesity. Exercise can reduce fat mass and promote browning of white adipose tissue (WAT), benefiting metabolic balance. Various factors like reactive oxygen species, metabolites, and lipolysis can facilitate exercise-mediated browning of WAT.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell Biology

Protein lactylation induced by neural excitation

Hideo Hagihara et al.

Summary: This study found that lysine lactylation in brain cells is regulated by neural excitation and social stress, with parallel changes in lactate levels. These stimuli increase lysine lactylation, resulting in increased expression of the neuronal activity marker c-Fos, as well as decreased social behavior and increased anxiety-like behavior in the stress model.

CELL REPORTS (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH

Gavin Fredrickson et al.

Summary: This study found that HIIT was more effective than MIT in improving the progression of NASH, with HIIT outperforming MIT in reducing hepatic steatosis, improving whole-body glucose tolerance, and ameliorating liver inflammation and fibrosis.

MOLECULAR METABOLISM (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Recruitment and remodeling of peridroplet mitochondria in human adipose tissue

Rebeca Acin-Perez et al.

Summary: This study demonstrates the existence of peridroplet mitochondria (PDM) as a separate functional entity in humans and shows that browning in both mice and humans is associated with a robust expansion of PDM characterized by increased ATP synthesis linked respiration.

REDOX BIOLOGY (2021)

添加到收藏夹

Correction Biochemistry & Molecular Biology

Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation (vol 39, e103304, 2020)

Yexian Yuan et al.

EMBO JOURNAL (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Jie Yu et al.

Summary: The study reveals that histone lactylation is increased in tumors, promoting tumorigenesis by facilitating YTHDF2 expression and degradation of m6A-modified PER1 and TP53 mRNA. This provides new therapeutic targets and insights into epigenetic regulation in tumorigenesis.

GENOME BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quantification of exercise-regulated ubiquitin signaling in human skeletal muscle identifies protein modification cross talk via NEDDylation

Benjamin L. Parker et al.

FASEB JOURNAL (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues

Audrey Carriere et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2020)

添加到收藏夹

Review Hospitality, Leisure, Sport & Tourism

The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU

George A. Brooks

JOURNAL OF SPORT AND HEALTH SCIENCE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lactate as a fulcrum of metabolism

George A. Brooks

REDOX BIOLOGY (2020)

添加到收藏夹

Article Neurosciences

High-intensity interval training and moderate-intensity continuous training alleviate β-amyloid deposition by inhibiting NLRP3 inflammasome activation in APPswe/PS1dE9 mice

Fei Liang et al.

NEUROREPORT (2020)

添加到收藏夹

Review Physiology

The Interplay Between Exercise Metabolism, Epigenetics, and Skeletal Muscle Remodeling

Robert A. Seaborne et al.

EXERCISE AND SPORT SCIENCES REVIEWS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Multifaceted role of branched-chain amino acid metabolism in cancer

Hui Peng et al.

ONCOGENE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exercise-induced AMPK activation and IL-6 muscle production are disturbed in adiponectin knockout mice

Tiego A. Diniz et al.

CYTOKINE (2019)

添加到收藏夹

Review Cell Biology

Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

Ann-Katrin Hopp et al.

CELLS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolic regulation of gene expression by histone lactylation

Di Zhang et al.

NATURE (2019)

添加到收藏夹

Review Medicine, Research & Experimental

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

Pascale Fisel et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phosphate-dependent luminal ATP metabolism regulates transcellular calcium transport in intestinal epithelial cells

Atsushi Uekawa et al.

FASEB JOURNAL (2018)

添加到收藏夹

Article Physiology

Muscle type-specific RNA polymerase II recruitment during PGC-1 alpha gene transcription after acute exercise in adult rats

Ryo Masuzawa et al.

JOURNAL OF APPLIED PHYSIOLOGY (2018)

添加到收藏夹

Review Neurosciences

Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation

Mark Evans et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exercise increases hyper-acetylation of histones on the Cis-element of NRF-1 binding to the Mef2a promoter: Implications on type 2 diabetes

Jitcy S. Joseph et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

添加到收藏夹

Article Oncology

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth

Huai-Peng Lin et al.

CANCER RESEARCH (2016)

添加到收藏夹

Review Hospitality, Leisure, Sport & Tourism

High-intensity interval training (HIIT) for patients with chronic diseases

Leanna M. Ross et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2016)

添加到收藏夹

Article Cell Biology

Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation

Katherine A. Overmyer et al.

CELL METABOLISM (2015)

添加到收藏夹

Article Cell Biology

Glutathione depletion and acute exercise increase O-GlcNAc protein modification in rat skeletal muscle

Tina Tinkara Peternelj et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)

添加到收藏夹

Review Cell Biology

Comprehensive review on lactate metabolism in human health

M. Adeva-Andany et al.

MITOCHONDRION (2014)

添加到收藏夹

Review Sport Sciences

A Review of Adolescent High-Intensity Interval Training

Greig R. M. Logan et al.

SPORTS MEDICINE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

Ruiting Lin et al.

MOLECULAR CELL (2013)

添加到收藏夹

Article Behavioral Sciences

Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus

Gisele Agustini Lovatel et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

Tom Latham et al.

NUCLEIC ACIDS RESEARCH (2012)

添加到收藏夹

Article Neurosciences

Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle

Taisuke Enoki et al.

JOURNAL OF PHYSIOLOGY-LONDON (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.