☆ 4.6 Review

Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers

FRONTIERS IN MOLECULAR BIOSCIENCES (2023)

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Summary: Lipids play essential roles in biological functions and mass spectrometry is the preferred method for lipid analysis. However, untargeted qualitative profiling and absolute quantitation of lipids are still challenging due to their structural diversity and similarity. Chemical derivatization techniques have been developed to improve lipidomic analysis, providing more structural information and better analytical performance.

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Summary: Anabolic androgenic steroids (AAS) are commonly used performance-enhancing drugs banned by WADA due to the competitive advantage they offer athletes. Mass spectrometry-based methods coupled with chromatographic separations are the gold standard for AAS analysis. Emerging analytical techniques, such as ion mobility spectrometry (IMS), have shown potential in further characterizing and identifying unknown compounds while improving sensitivity.

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Summary: This study aimed to develop tandem mass spectrometry-ion mobility spectrometry (MS/MS-IMS) methodologies to explore and understand the behavior of isomeric steroids in the gas-phase and rapidly separate them. Results showed that the behavior of isomeric steroids was influenced by factors such as adduct positioning and bending of the steroid ring. Data evaluation revealed the tendency of isomers to form homo-clusters in mixture solutions and assist in separation.

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Improved Ion Mobility Separation and Structural Characterization of Steroids using Derivatization Methods

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