A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells

Gastrointestinal (GI) cancer includes a variety of cancers with high incidence that seriously threaten the lives of people worldwide. Although treatment strategies continue to improve, patient benefits are still very limited, and the ongoing search for new treatment strategies remains a priority. Cell senescence is closely related to the occurrence and development of tumors. For GI cancer, cell senescence may not only promote cancer but also bring new opportunities for treatment. Combined with relevant studies, we review the dual role of cell senescence in GI cancer, including the mechanism of inducing cell senescence, biomarkers of senescent cells, and potential of targeted senescence therapy for GI cancer.

Automated summary

Gastrointestinal (GI) cancer is a type of cancer with high incidence that poses a serious threat to people worldwide. Despite advancements in treatment strategies, patient benefits are still limited, making the search for new treatment strategies a priority. Cell senescence plays a dual role in GI cancer, promoting cancer development but also providing new opportunities for treatment. This review explores the mechanism of inducing cell senescence, biomarkers of senescent cells, and the potential of targeted senescence therapy for GI cancer.