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Article
Immunology
Helene Ruffieux et al.
Summary: We analyzed detailed longitudinal phenotyping data from 215 individuals with varying disease severities to understand the biology behind individual patient responses to SARS-CoV-2 infection. Our findings revealed distinct profiles of 'systemic recovery', including the progression and resolution of inflammatory, immune cell, metabolic, and clinical responses. We identified strong correlations between innate immune cell numbers, kynurenine metabolites, and lipid metabolites, which have implications for homeostasis restoration, risk of death, and long COVID.
Article
Virology
Xiao-Kun Li et al.
Summary: Metabolic analysis of COVID-19 patients from Sierra Leone revealed the association between glutamine and glutamate metabolism and disease severity. Further analysis confirmed these findings and suggested that targeting these metabolic pathways could be a potential therapeutic approach for severe COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Analytical
Philipp Nitschke et al.
Summary: This study presents a J-Edited Diffusional (JEDI) proton NMR spectroscopic approach that selectively enhances signals from inflammatory markers in blood serum. The results show that JEDI is an improved method for selectively investigating inflammatory signals in serum and may have widespread diagnostic applicability to disease states associated with systemic inflammation.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yapeng Su et al.
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Article
Genetics & Heredity
Mojgan Masoodi et al.
Summary: This study found significant differences in plasma metabolic signatures between COVID-19 patients and control group, primarily in lipid and amino acid metabolism. Protein systems biology analysis revealed that COVID-19 mainly impacted sphingolipid, tryptophan, tyrosine, glutamine, arginine, and arachidonic acid metabolism pathways. Additionally, decreased levels of GABA could serve as a potential biomarker and therapeutic target for COVID-19 patients.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemical Research Methods
Oihane E. Alboniga et al.
Summary: In this study, untargeted metabolomics was used to identify novel metabolic pathways related to SARS-CoV-2 susceptibility and COVID-19 clinical severity. The researchers discovered several plasma biomarkers associated with SARS-CoV-2 infection, providing mechanistic explanations for the clinical consequences of the disease.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ivayla Roberts et al.
Summary: This study utilizes untargeted metabolomics analysis to evaluate 120 samples of COVID-19 patients and predict the severity and outcome of the infection. The study identifies a group of metabolites with relevant biological functions, such as deoxycytidine and ureidopropionate (indirectly reflecting viral load), kynurenine (reflecting host inflammatory response), and multiple short chain acylcarnitines (energy metabolism) that can predict disease severity and outcome.
Article
Biochemistry & Molecular Biology
Yan Xie et al.
Summary: Individuals with COVID-19, even those who were not hospitalized during the acute phase of the infection, are at an increased long-term risk of various cardiovascular disorders. A study using national healthcare databases found that beyond the first 30 days after infection, individuals with COVID-19 have an elevated risk of developing cerebrovascular disorders, heart diseases, and other cardiovascular complications. The risk increases depending on the care setting during the acute phase.
Review
Cell Biology
Cody B. Jackson et al.
Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Biophysics
Maider Bizkarguenaga et al.
Summary: COVID-19 is a systemic infectious disease that affects multiple organs, with half of the patients showing abnormal metabolism six months after infection. Most patients are asymptomatic or have mild symptoms, possibly reflecting the metabolic response to immune stress.
NMR IN BIOMEDICINE
(2022)
Article
Cell Biology
Xiaojie Bi et al.
Summary: This study analyzes the urinary and serum proteome and metabolome of COVID-19 patients and healthy controls. It finds that urinary proteins can effectively classify COVID-19 severity and identifies correlations between urinary proteins and active SARS-CoV-2 replication, as well as blood lymphocyte counts in severe cases. The study suggests that COVID-19 triggers innate immune activation and inflammation that lead to renal injuries. The modulation of the urinary proteome provides unique insights into the pathogenesis of COVID-19.
Article
Immunology
Andre F. Rendeiro et al.
Summary: This study investigated the blood metabolomic data of COVID-19 patients using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy and high-dimensional flow cytometry. The findings showed significant changes in serum metabolome composition associated with disease severity and response to therapy. The study established a clinically annotated, biologically-interpretable space for precise disease monitoring and characterized the temporal dynamics of metabolomic change and treatment response. The results demonstrate that joint immuno-metabolic measurements can be used for patient stratification and early prediction of severe disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Reika Masuda et al.
Summary: SARS-CoV-2 infection leads to a decrease in lipoprotein-bound serum phospholipids, resulting in supra-molecular phospholipid composite (SPC) signals detected in diffusion and relaxation edited H-1 NMR spectra. This study utilized Statistical HeterospectroscoY in n-dimensions (SHYn) approach to identify the major phospholipid components contributing to the SPC signals and correlated them with lipoprotein and lipid measurements. The SPC3/SPC2 ratio was strongly correlated with the apolipoprotein B100/A1 ratio, indicating the potential of serum SPC measurement as a metric of cardiovascular risk based on a single NMR experiment.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Michele Costanzo et al.
Summary: This review summarizes the diverse knowledge acquired through the application of COVIDomics techniques, focusing on proteomics and metabolomics studies, to identify common dysregulation in proteins, metabolites, and pathways in COVID-19 disease. Exploring the multiomics perspective and data integration may lead to new therapeutic solutions against the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Helena Castane et al.
Summary: The study found that COVID-19 infection shares many lipid alterations with other infectious/inflammatory diseases, but there are also some differences. The most notable alterations were observed in oxylipins in COVID-19 patients, while bile acids and glycerophospholipids best distinguished between COVID-19-positive and COVID-19-negative patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biology
Chen-Song Zhang et al.
Summary: By analyzing the serum metabolome and lipidome in COVID-19 patients at different stages, we identified significant alterations in 611 metabolites. Among them, agmatine and putrescine were prominently elevated, while 2-quinolinecarboxylate showed a biphasic change. These metabolites were found to activate the NF-kappa B pathway and induce strong proinflammatory cytokine production. Interestingly, they had limited effects on interferon production. These findings may provide insights for the development of drugs to alleviate inflammation in COVID-19 patients.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Virology
Soheila Montazersaheb et al.
Summary: COVID-19 caused by SARS-CoV-2 poses a significant global health threat, leading to pneumonia and ARDS in patients. Cytokine storm, characterized by elevated levels of pro-inflammatory cytokines, including interleukins and TNF-alpha, contributes to lung damage in ARDS patients. Suppressing the inflammatory response may be a possible strategy for managing COVID-19.
Article
Cell Biology
Rocio Diaz Escarcega et al.
Summary: The study finds sex differences in metabolism and sexual dimorphism in the correlations between clinical parameters and metabolic profiles in severe COVID-19 patients, providing important knowledge for the development of sex-associated biomarkers and druggable targets for COVID-19 patients.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Hongwei Li et al.
Summary: In COVID-19 survivors, about 41% reported at least one clinical symptom and 26.5% exhibited lung imaging abnormalities 6 months after discharge. Plasma proteomics and metabolomics analysis showed that COVID-19 survivors differed from healthy controls in terms of extracellular matrix, immune response, and hemostasis pathways. Moreover, COVID-19 survivors also exhibited abnormal lipid metabolism, disordered immune response, and changes in pulmonary fibrosis-related proteins.
CELL DEATH & DISEASE
(2022)
Article
Microbiology
Veronica Ghini et al.
Summary: By comparing the plasma composition of COVID-19 patients in the acute phase and recovered individuals, the study found that metabolite biomarkers can serve as timely indicators of treatment response or spontaneous healing. The research also revealed significant alterations in the concentrations of metabolites and lipoproteins in response to COVID-19 infection. Furthermore, the metabolome reverts back to a healthy state faster than the lipoproteome during the recovery process.
Article
Immunology
Meijia Gu et al.
Summary: In this study, a comprehensive analysis of clinical measurements and serum metabolomics in different stages of COVID-19 patients was conducted, identifying a series of biomarkers that could potentially be used for early intervention and disease course prediction. These biomarkers are involved in various pathological and physiological pathways of COVID-19, providing valuable information for understanding the pathogenesis and developing potential therapeutic agents.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Lucas Barbosa Oliveira et al.
Summary: This study used metabolomics to identify potential metabolic signatures for discriminating severe COVID-19 from non-severe cases. The results showed that metabolites from porphyrin and purine pathways were significantly elevated in the severe disease group, while elevated levels of cholesteryl ester in non-severe patients were consistent with differences in blood cholesterol components. Pathway analysis revealed the impact of COVID-19 on glycerophospholipid and porphyrin metabolism, particularly in the glycerophospholipid and linoleic acid metabolism pathways.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Yixian Jing et al.
Summary: Coronavirus disease 2019 (COVID-19) has become a global pandemic. Metabolomic studies in COVID-19 patients suggest that urinary metabolites may serve as screening methods for COVID-19 and have close interactions with host immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Ioanna Dagla et al.
Summary: Vaccination is highly effective in mitigating the COVID-19 pandemic. However, individual immune responses to mRNA vaccines vary significantly. Metabolomics analysis reveals distinct plasma metabolic profiles associated with immune response levels, indicating the potential of certain metabolites as predictive markers for vaccine response.
Article
Biochemistry & Molecular Biology
Veronica Ghini et al.
Summary: The H-1 NMR spectra of sera were used to analyze the changes induced by vaccination with Pfizer-BioNTech vaccine in COVID-19-recovered and COVID-19-naive subjects. The results show that vaccination does not significantly affect the metabolome, but causes changes in lipoprotein levels. The effects differ between the recovered and naive subjects, suggesting that prior infection reduces the vaccine's modulation of lipoprotein composition.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Marie Altendahl et al.
Summary: This study investigated the pathophysiology of COVID-19 in pregnant patients with different clinical trajectories. Severe COVID-19 was associated with distinct proteomic and lipidomic signatures related to complement and antibody activity. Mild/moderate COVID-19 did not show significant alterations compared to controls in serum protein, metabolite, or lipid metabolite levels.
Article
Multidisciplinary Sciences
Junru Wu et al.
Summary: Alterations in lipid metabolism and circulating lipid species have been reported in patients with acute critical illness. Here the authors show that selective rise in systemic phosphatidylethanolamine levels is a common feature of critical illness that associates with worse clinical outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Michele Ciccarelli et al.
Summary: This study utilized untargeted lipidomics to identify specific lipid profiles that can predict the severity and outcome of COVID-19 patients. These lipid profiles can be used for monitoring and targeted approaches during hospital admission.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Banny S. B. Correia et al.
Summary: This study used metabolomics to compare Covid-19 patients with a control group, revealing alterations in metabolite levels and identifying six metabolites that could potentially serve as prognostic markers for the disease. The metabolic changes observed suggest that SARS-CoV-2 infection disrupts the energetic system in the human body, supporting viral replication and correlating with the severity of clinical conditions in patients.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Multidisciplinary Sciences
John L. Robertson et al.
Summary: We developed a method to detect COVID-19 disease using urine specimens by analyzing the urine 'molecular fingerprint' representing systemic reactions to infection. The method showed high accuracy in detecting COVID-19 and assessing disease severity based on urine Raman spectra.
Article
Multidisciplinary Sciences
Zhu Yang et al.
Summary: This study compares the plasma cytokines and metabolome of convalescent COVID-19 patients and healthy individuals, and identifies potential associations between certain cytokines and metabolites and antibody fading. It also demonstrates that the DPP4 inhibitor sitagliptin can counteract the inhibitory effects of gly-pro on SARS-CoV-2 vaccination. These findings highlight the important role of gly-pro in the immune responses to SARS-CoV-2 infection and provide insights for therapeutic and vaccination strategies against COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Alex R. Schuurman et al.
Summary: This study reveals the profound impact of COVID-19 infection on the lipid composition of human platelets, and identifies associations between platelet lipid composition and reactivity.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Sean Bennet et al.
Summary: Respiratory viruses, including COVID-19, can affect the nasal metabolome, leading to virus-specific changes. This study evaluated the nasopharyngeal metabolome of COVID-19 infected individuals and identified potential therapeutic targets. Machine learning models accurately differentiated viral infections and specifically identified analytes that were significantly changed in COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Joseph P. Dewulf et al.
Summary: In this study, quantitative urine metabolomics analysis revealed significant increases in tryptophan metabolites in the urine of COVID-19 patients, which were associated with disease severity and systemic inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Matt Spick et al.
Summary: This study investigated the correlations between serum metabolites, salivary metabolites, and sebum lipids for the first time, and observed widespread alterations in serum-sebum lipid relationships in COVID-19 positive patients. The study also compared the ability of these biofluids to differentiate COVID-19 positive patients from controls, and found that serum performed best, followed by sebum, and saliva performed the worst.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Ilhame Diboun et al.
Summary: This study used metabolomics analysis to identify potential biomarkers for COVID-19 morbidity and mortality in patients with prior tuberculosis (TB) infection. The analysis showed that post-TB individuals had a higher severity of SARS-CoV-2 infection and mortality rate, with a decline in amino acids levels. Betaine and branched chain amino acids (BCAAs) were identified as potential metabolic biomarkers for severity and mortality in COVID-19 patients with TB exposure. Serum alanine was also identified as an important metabolite at the interface of severity and mortality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Francisco C. Ceballos et al.
Summary: Metabolic profiling of COVID-19 patients at disease onset is a powerful tool to unravel the molecular pathogenesis of SARS-CoV-2 and predict disease progression, while explaining the pronounced pathogenesis differences between sexes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jun Liu et al.
Summary: This study evaluated the serum metabolomic profiles of COVID-19 patients using targeted metabolomics. The results showed that metabolites performed well in discriminating COVID-19 patients from CAP patients and healthy controls. Specific dysregulation of certain metabolites was observed in severe COVID-19 patients. This study may enhance our understanding of the pathophysiological mechanisms of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Holly-May Lewis et al.
Summary: The impact of COVID-19 infection on human metabolism has been widely studied, but previous research focused on a single wave of infection. This study found that metabolic disturbance changed partially over the course of the pandemic, reflecting changes in variants, clinical presentation, and treatment regimes. Some metabolites were identified as robust indicators of COVID-19 infection across multiple waves. The research also supports the hypothesis that certain metabolic pathways remain disrupted several months after COVID-19 infection.
Article
Biochemistry & Molecular Biology
Naama Karu et al.
Summary: COVID-19 is characterized by dysregulated immune response, with signaling lipids mediating the inflammatory process. The study found that ICU patients had lower levels of specific lipids compared to ward patients, while recovering ward patients had higher levels. Additionally, ICU patients showed positive correlations between specific lipids and markers of macrophage activation, while recovering ward patients showed negative correlations with inflammation markers. Therefore, COVID-19 may disrupt oxylipin metabolism, hindering the expected shift from immune response to inflammation resolution.
Article
Biochemistry & Molecular Biology
Peter Liptak et al.
Summary: This study reveals metabolic changes in COVID-19 patients during the acute infection and one month after, indicating a persistent effect of the virus on metabolism. The random forest algorithm shows great discrimination between patients and controls based on metabolite levels.
Article
Multidisciplinary Sciences
Mustafa Buyukozkan et al.
Summary: In this study, large-scale integrative multi-omics analyses were conducted on serum samples from COVID-19 patients to uncover the pathogenic complexities and identify molecular signatures that predict clinical outcomes. A network of protein-metabolite interactions was assembled, revealing cross talk related to immune modulation, energy and nucleotide metabolism, vascular homeostasis, and collagen catabolism. A novel composite outcome measure for COVID-19 disease severity based on metabolomics data was developed and showed high predictive power.
Article
Biochemistry & Molecular Biology
Matt Spick et al.
Summary: Treatments for COVID-19 infections have improved, with glucocorticoids playing a key role in reducing mortality rates. However, a study has found that glucocorticoids are not fully effective in addressing the diverse range of 'omics dysregulation caused by COVID-19 infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jose C. Paez-Franco et al.
Summary: It is known that comorbidities and age-related health issues can affect the progression of COVID-19. In this study, metabolic changes in male patients with mild/moderate and severe COVID-19 were analyzed, revealing differences in serum levels of specific metabolites. Glutamine/glutamate metabolism was found to be associated with disease severity. These findings provide insights into potential supportive therapies for COVID-19 and other diseases involving altered redox homeostasis and lower oxygen levels.
Article
Multidisciplinary Sciences
Cecile F. Frampas et al.
Summary: Saliva metabolomics, particularly amino acids, can differentiate between high severity and low severity COVID-19 patients, expanding the understanding of COVID-19 metabolic dysregulation and potentially providing a non-invasive means of sampling patients for timely treatment.
Article
Pharmacology & Pharmacy
Wenyu Chen et al.
Summary: This study utilized untargeted metabolomics analysis to characterize the metabolic alterations in COVID-19 patients with nucleic acid turning negative. The results showed dysregulation in amino acid metabolism and lipid metabolism, highlighting the need for specific post-treatment care to aid the recovery of COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Maozhang He et al.
Summary: The study revealed that SARS-CoV-2 vaccination significantly affects the host metabolite levels, with certain metabolites such as L-glutamic acid, GABA, succinic acid, and taurine showing an increasing trend post-vaccination. Additionally, post-vaccination metabolites were mainly associated with butanoate metabolism and glutamate metabolism pathways and demonstrated a high discriminative ability between vaccinated and unvaccinated individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Misato Kida et al.
Summary: This study comprehensively analyzed urinary lipid mediators and their metabolites in COVID-19 patients and found that urinary lipids can reflect the inflammatory status of patients, which may serve as a useful index for managing the disease.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Makoto Kurano et al.
Summary: This study investigated the modulations of sphingolipids and glycerophospholipids in COVID-19 patients, revealing their dynamic changes depending on the time course and severity of the disease. Several species of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin may serve as better biomarkers for predicting severe COVID-19 during the early phase compared to traditional markers such as CRP and D-dimer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rasmus Remy et al.
Summary: Breath analysis can provide immediate information on infection mechanisms and host response. This study found that the VOC profiles in exhaled breath differed between COVID-19 patients and healthy individuals or those with other respiratory infections. The downregulation of specific VOCs may be attributed to the suppressive effects of the virus on gut or pulmonary microbial metabolism.
Article
Multidisciplinary Sciences
Fang Li et al.
Summary: This study used metabolomics approaches to investigate the metabolic characteristics of non-severe COVID-19 survivors and found that their serum amino acids, organic acids, purine, fatty acids, and lipid metabolism were still abnormal, but the kynurenine pathway and the level of itaconic acid had returned to normal. These metabolic abnormalities are associated with liver injury, mental health, energy production, and inflammatory responses.
Article
Medical Informatics
Seul Kee Byeon et al.
Summary: In this retrospective cohort study, biomarkers that reliably predict severe and clinical outcomes of COVID-19 were discovered by analyzing samples from 455 participants. The study found that multiomic molecular signatures in plasma collected before hospital admission could be used to predict disease severity, demonstrating the potential of machine learning approaches in identifying novel clinical signatures.
LANCET DIGITAL HEALTH
(2022)
Article
Cell Biology
Makoto Kurano et al.
Summary: This study investigated the urinary modulations of sphingolipids and glycerophospholipids in COVID-19 patients with kidney injuries. The results showed significant changes in the levels of certain compounds in the urine, which may reflect the direct effects of viral infection.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Immunology
Laura E. Martinez-Gomez et al.
Summary: This study aimed to characterize the profile of amino acids and acylcarnitines in COVID-19 patients. The findings suggest that metabolic imbalance may affect disease progression in COVID-19 patients, and phenylalanine may serve as a potential metabolic biomarker for evaluating disease severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Narjes Saheb Sharif-Askari et al.
Summary: This study investigated the utility of saliva and plasma metabolomic profiles as potential parameters for risk stratifying COVID-19 patients. LC-MS/MS-based untargeted metabolomics were used to profile changes in saliva and plasma metabolites of COVID-19 patients, revealing significant differences in metabolites between infected and non-infected individuals. Saliva-specific metabolites could serve as diagnostic and prognostic biomarkers for COVID-19.
Article
Biochemistry & Molecular Biology
Mingshan Xue et al.
Summary: This study investigates the clinical practice of phospholipid metabolic pathways in COVID-19 patients. It reveals that phosphatidylinositol and phosphatidylcholine can differentiate patients from healthy controls and predict the severity of the disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Malena M. Perez et al.
Summary: The study suggests that high levels of lipid and cholinergic mediators are associated with pulmonary and systemic hyperinflammation in severe cases of COVID-19. The use of glucocorticoids is associated with the survival of critical patients and a reduction in ACh levels.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
L. R. Dillard et al.
Summary: This study investigates the metabolic signatures of non-acute and severe COVID-19 samples and finds that non-acute infection is associated with inhibited inflammatory response, while severe infection is linked to musculoskeletal degeneration and hijacked host metabolism. The findings highlight the metabolic transition from innate immune response to inflammatory and metabolic dysfunction in severe COVID-19.
Review
Virology
Benjamin Gallo Marin et al.
Summary: The severity and mortality of COVID-19 may be associated with patient age, multiple comorbidities, hypoxia, extensive lung involvement on CT scans, laboratory abnormalities, and biomarkers of end-organ dysfunction.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Chemistry, Analytical
Feixiang He et al.
Summary: The gut ecosystem has profound effects on host physiology and health, with COVID-19 causing disruptions in gut proteomes. These disruptions may play a role in the development of symptoms in COVID-19 and highlight the need for ongoing investigation into gut molecular and microbial alterations during the recovery process.
ANALYTICA CHIMICA ACTA
(2021)
Review
Medical Laboratory Technology
Baoxu Lin et al.
Summary: Sequencing the SARS-CoV-2 genome is crucial for controlling the COVID-19 pandemic. Comprehensive analysis of the molecular characteristics of SARS-CoV-2 and changes in COVID-19 patients is important for developing detection assays and treatment strategies. Omics research on COVID-19 offers hope for diagnostic assays, biomarkers, therapeutic drugs, and vaccines.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2021)
Article
Virology
Halef O. Dogan et al.
Summary: COVID-19 patients and healthy controls exhibit significant differences in metabolites such as purine, glutamine, leukotriene D4, and glutathione metabolism, suggesting their roles in the pathogenesis of the disease. Targeting these pathways with therapeutic approaches like selective leukotriene D4 receptor antagonists and glutamine supplementation may reduce the severity and mortality of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemical Research Methods
Samantha Lodge et al.
Summary: The study demonstrates that low sample volume H-1 NMR spectroscopic experiments under in vitro diagnostic conditions can effectively recover information from blood plasma with limited availability or high value samples. Lipoprotein measurements using different volumes of NMR tubes showed similar results, with no time penalty for biomarker recovery for SARS-CoV-2.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemical Research Methods
Samantha Lodge et al.
Summary: The study investigated the systemic metabolic effects of SARS-CoV-2 infection by analyzing H-1 NMR spectroscopic data on human blood plasma. The findings revealed that some patients in the respiratory recovery phase, with no detectable virus, still exhibited highly abnormal metabolism, indicating a new role for these technologies in assessing full systemic recovery.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Cell Biology
Usman M. Ashraf et al.
Summary: The novel coronavirus disease COVID-19 has posed a global challenge by infecting human cells via binding with ACE2, resulting in respiratory illnesses like bronchitis and pneumonia.
PHYSIOLOGICAL GENOMICS
(2021)
Article
Biochemistry & Molecular Biology
Faisal A. Alzahrani et al.
Summary: This study investigated the metabolite content of EVs isolated from the serum of COVID-19 patients, revealing the presence of antivirals, antibiotics, anti-inflammatory metabolites, and decreased levels of coagulation-related metabolites. These findings suggest that EVs may play a crucial role in mediating heightened inflammation during COVID-19 infection, paving the way for the identification of novel metabolites as regulators of inflammatory pathways during viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Enrica Torretta et al.
Summary: This study found that the imbalance of sphingolipid and glycosphingolipid metabolism in COVID-19 patients is related to disease severity, potentially leading to lipid raft remodeling, inducing cell apoptosis and immune escape.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Stanislas Grassin-Delyle et al.
Summary: This study characterized the exhaled breath from mechanically ventilated adults with COVID-19 using real-time proton transfer reaction time-of-flight mass spectrometry. The analysis was able to differentiate between COVID-19 and non-COVID-19 ARDS with high accuracy. Characteristic volatile compounds were identified in the exhaled breath of COVID-19 patients, showing potential for early diagnosis.
Article
Chemistry, Analytical
Samantha Lodge et al.
Summary: Nuclear magnetic resonance spectroscopy-based plasma phenotyping using DIRE technique successfully revealed diagnostic molecular signatures of SARS-CoV-2 infection in plasma. Comparison of plasma samples from different groups showed differences in concentrations of specific metabolites in SARS-CoV-2 positive patients, suggesting potential molecular markers for COVID-19 diagnosis.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yunpeng Bai et al.
Summary: This study used a lipidomic strategy to analyze plasma lipids in cured COVID-19 patients of different ages and symptoms, finding more significant lipidomic changes in patients with severe symptoms or elderly patients. Some of these lipids may have essential biological functions, providing valuable information for potential therapeutic targets of COVID-19.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Francois-Xavier Danlos et al.
Summary: The circulating metabolome provides insights into how the organism responds to pathogenic challenges. Alterations in the plasma metabolome of COVID-19 patients varied based on the severity of the disease, with major changes observed in critical patients compared to mild cases. Understanding these metabolic shifts could potentially help in identifying therapeutic targets for COVID-19.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Marianna Caterino et al.
Summary: This study utilized targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement to investigate the serum of COVID-19 patients with different severity degrees. The study measured serum IL-26, a cytokine involved in the IL-17 pathway, TSLP, and adiponectin, and correlated them with lipid profiles of COVID-19 patients, providing important insights for the classification of the disease and the identification of therapeutic targets.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Michele Dei Cas et al.
Summary: The serum lipidome of COVID-19 patients shows significant and unique dyslipidemia related to factors such as inflammation, hypoxia, coagulation state, kidney function, and age, indicating reduced defense against oxidative stress. A particular lipidome signature was identified in patients with different outcomes after 7 days, with an increase in specific lipid species like ceramides and sulfatides, potentially serving as biomarkers for disease progression and severity.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Longxian Lv et al.
Summary: COVID-19 patients' faecal metabolome is enriched with important nutrients and harmful metabolites, with certain metabolites significantly correlated with altered serum metabolites and gut microbes; discharged patients' faecal metabolites showed no difference in some components compared to healthy controls, but significant differences were observed in others, reflecting potential malnutrition and intestinal inflammation.
ANALYTICA CHIMICA ACTA
(2021)
Article
Microbiology
Tao Li et al.
Summary: Studies on the metabolome of COVID-19 patients have revealed metabolic disorders and potential diagnostic markers during disease progression. Longitudinal changes in the serum metabolome of COVID-19 patients show that most metabolites did not recover before discharge. Dysregulation of the ornithine cycle significantly correlates with inflammation and coagulation in severe patients, potentially contributing to the pathogenicity of COVID-19.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhigang Ren et al.
Summary: This study characterized the oral microbiome in patients with COVID-19, showing decreased microbial diversity and changes in specific bacteria. The study also identified potential biomarkers for diagnosing COVID-19 with high accuracy across different regions and successfully distinguished recovered patients from active patients based on lipid profiles.
Article
Biochemistry & Molecular Biology
Judith Marin-Corral et al.
Summary: Analysis of metabolic pathways in COVID-19 patients revealed associations with disease severity. Factors such as obesity, respiratory rate, and blood pressure were linked to severity, while changes in ceramide metabolism and tryptophan degradation correlated with inflammation. The metabolomic profile could potentially aid in stratifying disease severity and guiding clinical decisions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Rebecca A. Ward et al.
Summary: The field of infectious diseases needs to shift towards a precision approach to infection prevention, targeting high-risk patients and deploying specific preventative measures, while integrating machine learning and omics technologies to improve prediction accuracy.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Elettra Barberis et al.
Summary: Researchers used metabolomics analysis of exhaled breath condensate to discover potential biomarkers for noninvasive diagnosis and monitoring of COVID-19. They found that fatty acids in EBC can differentiate COVID-19 patients and may have a protective effect, suggesting their potential use as a preventive strategy against the infection.
Article
Biochemical Research Methods
Elaine Holmes et al.
Summary: The multivariate metabotyping approach was used to assess functional recovery of nonhospitalized COVID-19 patients. It revealed that some patients experienced persistent symptoms after acute infection, suggesting potential biochemical sequelae of Post-Acute COVID-19 Syndrome.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Endocrinology & Metabolism
Ding Shi et al.
Summary: The serum metabolome of COVID-19 patients is distinctive and can be used for investigating pathogenesis, determining a diagnosis, predicting severe cases, and improving treatment. Specific metabolites were found to distinguish COVID-19 patients from healthy controls and predict disease progression, with some being recovered after discharge.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Multidisciplinary Sciences
Jose C. Paez-Franco et al.
Summary: Using gas chromatography coupled to mass spectrometry, we identified significant changes in serum metabolites associated with severe and mild COVID-19 patients, particularly in altered amino acid catabolism. The study found that three alpha-hydroxyl acids of amino acid origin increased with disease severity, correlating with changes in oxygen saturation levels and clinical markers of lung damage. The conversion of alpha-keto acids to alpha-hydroxyl acids is suggested to play a role in maintaining NAD recycling in patients with altered oxygen levels during SARS-CoV-2 infection, highlighting the potential importance of amino acid supplementation.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Heli Julkunen et al.
Summary: Metabolic biomarkers are associated with susceptibility to severe COVID-19 and pneumonia, with both short-term and long-term risks being equally significant. Elevated levels of metabolic biomarkers may indicate higher risk of developing severe pneumonia within the first few years after measurement. These findings suggest that metabolic biomarker profiling could be a valuable tool in identifying individuals at high risk for severe infections.
Article
Cardiac & Cardiovascular Systems
Chiara Bruzzone et al.
Summary: Metabolic syndrome (MetS) is a complex condition without a clear medical definition. This study used NMR metabolomics to analyze urine samples from a European cohort, revealing a unique molecular signature of MetS. The results showed that MetS progression is associated with specific changes in the urine metabolome, which can be used to identify individuals with MetS and provide insight into the transitional states between healthy individuals and MetS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Biochemical Research Methods
Reika Masuda et al.
Summary: This study utilized NMR technology to analyze plasma lipoprotein and metabolite profiles of COVID-19 patients in Spain and Australia, revealing high similarity in lipoproteins but minor differences in metabolites between the two cohorts. Significant infection-related reductions in specific lipoprotein subfractions associated with negative regulation of blood coagulation and fibrinolysis were observed, demonstrating the potential of NMR-based technologies in identifying biomarkers for COVID-19.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yuping Cai et al.
Summary: This study reveals a specific link between the serum metabolomes and immune responses in male COVID-19 patients, with the metabolite kynurenic acid (KA) playing a key role in influencing clinical outcomes and immune responses in a sex-specific manner.
Article
Multidisciplinary Sciences
Peng Wu et al.
Summary: The authors conducted blood sampling and multi-omics analysis on COVID-19 patients of various disease severities, reporting a trans-omics landscape of COVID-19. The study found differences in characteristics between patients with different disease severities, suggesting potential clues for pathophysiology and therapeutic strategies of COVID-19.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yamile Lopez-Hernandez et al.
Summary: Research using targeted metabolomics identified potential biomarkers for predicting the course of COVID-19, with panels including specific metabolites showing promising results in distinguishing different patient groups. If further studies confirm the diagnostic value of these plasma biomarkers, they could be used in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Elettra Barberis et al.
Summary: This study identified a metabolic phenotype that may protect individuals from SARS-CoV-2 infection, with circulating monolaurin potentially playing a defensive role. Additionally, individuals with higher levels of cholesterol are at a greater risk of developing COVID-19. Metabolomics can aid in personalized medicine development and support public healthcare strategies.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Alhaji H. Janneh et al.
Summary: Changes in sphingolipids are closely related to the development of COVID-19, with reduced levels of sphingosine potentially serving as a sensitive biomarker for the early identification of symptomatic and asymptomatic COVID-19 patients.
SCIENTIFIC REPORTS
(2021)
Review
Genetics & Heredity
Mohammad Rubayet Hasan et al.
Summary: The COVID-19 pandemic has driven the development of rapid and inexpensive diagnostic tools, including alternative methods based on SARS-CoV-2 RNA and proteins, as well as metabolomics approaches. These new technologies can help in early detection and control of cases, while also making progress in the discovery of prognostic markers for the disease.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Angelo D'Alessandro et al.
Summary: This large study analyzed metabolic features of COVID-19 patients and found significant changes in amino acid and fatty acid/acylcarnitine metabolism as relevant markers of disease severity, progression, and prognosis. Machine learning models achieved around 78% prediction accuracy when trained with metabolomics and clinical data from half of the patient cohort, providing a foundation for further research and data sharing opportunities.
Article
Biochemistry & Molecular Biology
Nicola Gray et al.
Summary: Using lipid profiling and multivariate modeling, a refined panel of discriminant features from different lipid subclasses was developed to effectively differentiate between SARS-CoV-2 infection, healthy controls, and non-SARS-CoV-2 respiratory infections. The analysis showed strong predictive power and potential for facilitating accurate diagnosis and clinical management of the virus.
Article
Multidisciplinary Sciences
Yanhong Hao et al.
Summary: By performing comprehensive lipidomic characterization of serum samples from asymptomatic COVID-19 patients and healthy controls, a panel of key lipids that could accurately identify asymptomatic patients was screened out, revealing unique lipid metabolic dysregulation.
Article
Multidisciplinary Sciences
Paulo D'Amora et al.
Summary: This study investigated the association between host metabolic signatures and COVID-19 infection, finding that changes in specific metabolite concentrations could serve as predictors of disease severity and mortality. By analyzing metabolic profiles, individuals at higher risk of developing severe complications from COVID-19 infection could be identified, aiding in prognosis, risk stratification, and clinical management. Metabolic factors measured through plasma-based biochemical signatures may play a crucial role in determining the severity of Covid-19 and its implications for patient outcomes.
Article
Critical Care Medicine
Jose Angel Lorente et al.
Summary: This study compared the metabolic alterations induced by COVID-19 and Influenza A pneumonia (IAP) in ARDS patients, finding that these two conditions lead to different regulation of metabolic pathways. COVID-19 patients experience a significant energy supply deficit, while IAP patients exhibit more marked inflammatory and oxidative stress responses. The findings suggest a potential biomarker for diagnosing, prognosticating, and managing ARDS patients with different etiologies.
Article
Multidisciplinary Sciences
Mehran M. Khodadoust
Summary: The study suggests a causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients, with ceramide class lipids exhibiting a significant increase in infected patients. Specific subclasses of ceramides were shown to be greatly increased in plasma samples with respiratory distress, highlighting the potential value of monitoring plasma ceramide concentration for assessing the effects of therapies on COVID-19 respiratory distress patients.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Miriam Sindelar et al.
Summary: Through untargeted metabolomics analysis of plasma from COVID-19 patients, a predictive model of disease severity was established based on metabolic profiles, including metabolites directly related to disease progression that return to baseline levels upon recovery. These metabolites were also validated to be altered in a hamster model of COVID-19.
CELL REPORTS MEDICINE
(2021)
Article
Endocrinology & Metabolism
Sin Man Lam et al.
Summary: This study analyzed exosome-enriched extracellular vesicles from patients at different stages of COVID-19, highlighting dysregulated lipid metabolism in the hyperinflammatory phase and distinct metabolic and transcriptional responses triggered by EVs from different temporal phases in recipient cells. The results provide insights into cellular lipid metabolism and inter-tissue crosstalk at different stages of COVID-19 and contribute to understanding metabolic dysregulation in COVID-19.
Article
Medicine, General & Internal
Matt Spick et al.
Summary: The study revealed lower lipid levels in COVID-19 positive patients, indicating dyslipidemia. Sebum sampling showed potential for distinguishing between COVID-19 positive and negative patients based on lipidomic analysis.
Article
Biochemistry & Molecular Biology
Yuming Li et al.
Summary: This study identified potential therapeutic targets and biomarkers for predicting disease severity in COVID-19 patients through multi-platform omics analysis, with validation of predictive power.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Editorial Material
Public, Environmental & Occupational Health
Thirumalaisamy P. Velavan et al.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2020)
Article
Biochemistry & Molecular Biology
Bo Shen et al.
Review
Biochemistry & Molecular Biology
Francesca Coperchini et al.
CYTOKINE & GROWTH FACTOR REVIEWS
(2020)
Article
Biochemistry & Molecular Biology
Waradon Sungnak et al.
Review
Medical Laboratory Technology
Marco Ciotti et al.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2020)
Review
Biochemical Research Methods
Hanie Esakandari et al.
BIOLOGICAL PROCEDURES ONLINE
(2020)
Letter
Hematology
Itxaso San Juan et al.
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Cell Biology
Jin-Wen Song et al.
Article
Medicine, Research & Experimental
Tiffany Thomas et al.
Article
Biochemical Research Methods
Torben Kimhofer et al.
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Multidisciplinary Sciences
H. Blasco et al.
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Chiara Bruzzone et al.
Article
Biochemistry & Molecular Biology
Elettra Barberis et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Letter
Biochemistry & Molecular Biology
Yin Zhao et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Review
Respiratory System
Inke R. Koenig et al.
EUROPEAN RESPIRATORY JOURNAL
(2017)
Review
Health Care Sciences & Services
Luc Bissonnette et al.
JOURNAL OF PERSONALIZED MEDICINE
(2012)
Article
Multidisciplinary Sciences
Christabelle J. Darcy et al.
Editorial Material
Multidisciplinary Sciences
Jeremy K. Nicholson et al.
Article
Multidisciplinary Sciences
WH Li et al.
