期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2023.1157651
关键词
SARS-CoV-2; long COVID; post-acute sequelae of SARS-CoV-2 infection; PASC; post COVID condition
The emergence of persistent ill-health in the aftermath of SARS-CoV-2 infection has presented significant challenges. The symptoms of long COVID are highly variable and the underlying pathophysiology remains poorly understood. Current potential therapies are being investigated, but no proven effective treatment exists.
The emergence of persistent ill-health in the aftermath of SARS-CoV-2 infection has presented significant challenges to patients, healthcare workers and researchers. Termed long COVID, or post-acute sequelae of COVID-19 (PASC), the symptoms of this condition are highly variable and span multiple body systems. The underlying pathophysiology remains poorly understood, with no therapeutic agents proven to be effective. This narrative review describes predominant clinical features and phenotypes of long COVID alongside the data supporting potential pathogenesis of these phenotypes including ongoing immune dysregulation, viral persistence, endotheliopathy, gastrointestinal microbiome disturbance, autoimmunity, and dysautonomia. Finally, we describe current potential therapies under investigation, as well as future potential therapeutic options based on the proposed pathogenesis research.
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