CD38+CD58-is an independent adverse prognostic factor in paediatric Philadelphia chromosome negative B cell acute lymphoblastic leukaemia patients

To explore new risk predictors for a high risk of relapse in Philadelphia chromosome negative (Ph-) B cell acute lymphoblastic leukaemia (B-ALL) patients, 196 paediatric Ph-B-ALL patients (<= 18 years) were retrospectively analysed. We mainly focus on investigating the prognostic value of CD38 and CD58 expression in leukemic blasts in these patients by four colour flow cytometry. The CD38+ CD58-group (n = 16) had a higher relapse rate, a shorter 3-year event-free survival (EFS) and overall survival (OS) than the CD38+ CD58+ group (n = 157; 31.3% vs 10.2%, P = 0.04; 52.4% vs 92.3%, P < 0.01; 32.5% vs 91.0%, P = 0.01); CD38+ CD58-was an independent adverse prognostic predictor for relapse (hazard ratio [HR], 0.203; 95% CI, 0.063-0.656; P = 0.01), 3-year EFS (HR, 0.091; 95% CI, 0.023-0.355; P < 0.01) and OS (HR, 0.102; 95% CI, 0.026-0.3971; P < 0.01) in this cohort, as determined by Cox multivariate analysis. We identified, for the first time, a higher risk population of paediatric Ph- B-ALL patients with CD38+ CD58-who had a higher relapse risk and a shorter survival. Our results may allow better risk stratification and individualized treatment. (C) 2016 Published by Elsevier Ltd.