期刊
MICROORGANISMS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms11061562
关键词
immunocompromise; SARS-CoV-2; variants; protracted infection; B-and T-cell immunity
类别
Immunocompromised individuals with COVID-19 have higher risk, and studying their disease courses and immune responses is crucial. By analyzing the immune response of an immunocompromised individual with a prolonged SARS-CoV-2 infection, we provide insights into the interplay between B- and T-cell immunity in clearing the virus.
Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual's immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据