期刊
LEUKEMIA & LYMPHOMA
卷 58, 期 4, 页码 941-949出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2016.1219900
关键词
Monoclonal gammopathy; multiple myeloma; thrombin generation; venous thromboembolism; hypercoagulability
资金
- Mary Overton Award, Royal Adelaide Hospital Research Committee, South Australia
The prothrombotic risk in multiple myeloma (MM) could be potentially assessed by thrombin generation (TG) assays. TG was performed using Calibrated Automated Thrombography with 5 and 1 pM tissue factor. We compared baseline TG among 24MM patients, 19 MGUS, and 50 healthy controls, and assessed change in TG in MM patients during the initial treatment period at 1, 2, and 3 months. MM subjects demonstrated increased FVIII and VWF: Ag levels pretreatment, and a prothrombotic TG phenotype with increased velocity index, reduced lag time and time-to-peak, and increased resistance to thrombomodulin inhibition. There were no significant changes in TG with treatment for the majority of parameters, however, MM subjects exhibited persistent elevation of velocity index throughout treatment. Two subjects developed thrombosis during the study period despite thromboprophylaxis. This study provides information on the optimal conditions for examining TG as a predictor of thrombotic risk in MM patients.
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