☆ 4.6 Review

The Interplay between Candida albicans, Vaginal Mucosa, Host Immunity and Resident Microbiota in Health and Disease: An Overview and Future Perspectives

MICROORGANISMS (2023)

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Review Biochemistry & Molecular Biology

Candidalysin: Connecting the pore forming mechanism of this virulence factor to its immunostimulatory properties

Charles M. Russell et al.

Summary: Candida albicans is a deadly pathogen that causes millions of mucosal and systemic infections per year. The peptide candidalysin plays a key role in the pathophysiology by damaging cell membranes and activating immune responses. Recent research has revealed a novel self-assembly mechanism of candidalysin, which opens up new therapeutic opportunities for treating Candida infections.

JOURNAL OF BIOLOGICAL CHEMISTRY (2023)

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Review Immunology

Vulvovaginal candidiasis and vaginal microflora interaction: Microflora changes and probiotic therapy

Zhongwen Sun et al.

Summary: The vaginal microbiome has a significant impact on health and disease. Candida species, such as Candida albicans, are part of the mucosal flora of most healthy women. Changes in vaginal microflora during vulvovaginal candidiasis (VVC) infection and the potential use of lactic acid bacteria as probiotics to treat VVC are discussed in this review.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

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Article Microbiology

A New Phenotype in Candida-Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains

Arianna Sala et al.

Summary: Despite a high incidence of VVC, our understanding of this female-specific disease is still limited, and it has become a public health issue due to its negative impact on women's quality of life. It is not yet possible to determine if a specific Candida albicans strain is more likely to cause VVC based on genotype or laboratory phenotype. VVC affects nearly 3/4 of women and significantly reduces their quality of life.

MBIO (2023)

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Article Microbiology

Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins

Jonathan P. Richardson et al.

Summary: The study identifies the first family of peptide toxins, called candidalysins, in human-pathogenic fungi. These toxins are secreted by Candida albicans, Candida dubliniensis, and Candida tropicalis, and are responsible for causing cell damage, calcium influx, and activation of signaling pathways and cytokine secretion. Candidalysins from C. dubliniensis and C. tropicalis exhibit higher damaging and activation potential than C. albicans candidalysin, with faster membrane binding and disruption.

MBIO (2022)

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Review Immunology

Pathogenesis and virulence of Candida albicans

Jose Pedro Lopes et al.

Summary: This review synthesizes our current knowledge of tissue-specific determinants of Candida albicans pathogenicity and host immune defense mechanisms.

VIRULENCE (2022)

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Article Microbiology

Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity

De-Dong Li et al.

Summary: This study reveals the mechanism of metabolic remodeling in neutrophils during the immune response against fungal pathogens. Neutrophils upregulate glucose uptake by selectively expressing glucose transporter 1 (Glut1), which enhances their immune response against Candida albicans infection. The host-pathogen interaction also increases glycolytic activity in neutrophils through regulating Glut1 expression, localization, and function.

CELL HOST & MICROBE (2022)

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Article Infectious Diseases

Characteristics associated with Lactobacillus iners-dominated vaginal microbiota

Juliano Novak et al.

Summary: The study in Brazilian women of reproductive age found associations between L. iners-dominated microbiota with having multiple sexual partners, detection of Candida sp. in vaginal smears, lack of condom use, lower educational levels, and diet with milk/dairy intake. These findings suggest that unprotected sex practices and certain sociodemographic factors may help identify women with suboptimal protective properties of L. iners-dominated microbiota, warranting further investigation.

SEXUALLY TRANSMITTED INFECTIONS (2022)

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Article Immunology

Divergent EGFR/MAPK-Mediated Immune Responses to Clinical Candida Pathogens in Vulvovaginal Candidiasis

Jingyun Zhang et al.

Summary: Vulvovaginal candidiasis is characterized by inflammatory responses in the vagina caused by Candida albicans and non-albicans Candida species. This study found that different Candida strains and species induce different host immune responses and epithelial damage. The EGFR-MAPK signaling pathway plays an important role in the pathogenesis of vulvovaginal candidiasis.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Microbiology

Towards a deeper understanding of the vaginal microbiota

Michael France et al.

Summary: The vaginal microbiota plays a crucial role in vaginal health, with lactobacilli being dominant but other microbes also present. Lack of lactobacilli is associated with adverse health outcomes. The mechanisms behind these associations are not well understood, and more research on causative relationships is needed.

NATURE MICROBIOLOGY (2022)

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Review Microbiology

Role of Vaginal Mucosa, Host Immunity and Microbiota in Vulvovaginal Candidiasis

Subatrra Nair Balakrishnan et al.

Summary: Vulvovaginal candidiasis is a prevalent gynecological disease, and the use of vaginal epithelial cells and microbiota can alleviate the burden of the disease.

PATHOGENS (2022)

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Article Medicine, General & Internal

Antibiotic Therapy and Vaginal Microbiota Transplantation Reduce Endometriosis Disease Progression in Female Mice via NF-κB Signaling Pathway

Feilei Lu et al.

Summary: Endometriosis is a common gynecological disease characterized by estrogen-dependent inflammation and discomfort. Surgical resection and drug therapy are the main treatments, but they have limitations. This study found that vaginal antibiotics and vaginal microbiota transplantation can effectively treat endometriosis in mice.

FRONTIERS IN MEDICINE (2022)

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Article Medicine, General & Internal

Differential Vaginal Microbiota Profiling in Lactic-Acid-Producing Bacteria between Infertile Women with and without Chronic Endometritis

Suguru E. Tanaka et al.

Summary: This study found that certain bacteria in the vaginal secretions microbiota have significantly lower detection rates and abundance in CE patients compared to non-CE group, suggesting the potential of using vaginal secretions microbiota for predicting CE. This provides a new approach for the diagnosis and prediction of CE using less invasive VS sampling rather than intrauterine interventions.

DIAGNOSTICS (2022)

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Article Immunology

Mucosal Infection with Unmasked Candida albicans Cells Impacts Disease Progression in a Host Niche-Specific Manner

Andrew S. Wagner et al.

Summary: This study investigates the impact of beta(1, 3)-glucan unmasking on the progression of two manifestations of candidiasis: oropharyngeal candidiasis (OPC) and vulvovaginal candidiasis (VVC). The results show that increased unmasking attenuates fungal burden and prolongs survival in systemic infection. However, in OPC, selection for suppressor mutants that no longer display increased unmasking occurs, leading to restoration of fungal burden trends. In VVC, unmasked cells increase recruitment of polymorphonuclear cells and interleukin-1beta levels within the vaginal lumen. These findings suggest a niche-specific impact of unmasking on disease progression.

INFECTION AND IMMUNITY (2022)

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Article Food Science & Technology

Candidalysin Is the Hemolytic Factor of Candida albicans

Selene Mogavero et al.

Summary: Candidalysin, a peptide toxin produced by Candida albicans, is identified as the hemolytic factor of the organism. Its hemolytic activity is regulated by the P7 peptide. The purinergic receptor antagonist PPADS can neutralize the hemolytic effect of candidalysin and also affects its membrane intercalation ability. Antibodies targeting candidalysin show potential for neutralization and future anti-Candida therapy.

TOXINS (2022)

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Article Immunology

Vaginal Lactobacillus iners abundance is associated with outcome in antibiotic treatment of bacterial vaginosis and capable of inhibiting Gardnerella

Rui Zhou et al.

Summary: Seven Gardnerella genomospecies were detected in Chinese BV patients, but no association between their distribution and BV occurrence or prognosis was found. The relative abundance of L. iners was higher in cured patients, and its antimicrobial activity against G. vaginalis and F. vaginae was validated.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Infectious Diseases

Polymicrobial Infections and Biofilms: Clinical Significance and Eradication Strategies

V. T. Anju et al.

Summary: This review focuses on polymicrobial interactions and therapeutic interventions for polymicrobial biofilms. Deciphering the mechanisms of polymicrobial interactions and microbial diversity in chronic infections is of great significance for antimicrobial research.

ANTIBIOTICS-BASEL (2022)

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Article Cell Biology

The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways

Francios A. B. Olivier et al.

Summary: This study develops an imaging assay to investigate the mechanisms of Candida hyphae escape. The findings demonstrate that Candida uses pore-forming proteins, including candidalysin and Gasdermin D, to permeabilize macrophage membranes. Additionally, the study identifies macrophage extracellular trap formation as an additional pathway facilitating hyphal escape.

CELL REPORTS (2022)

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Article Biology

The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

Charles M. Russell et al.

Summary: In this study, the mechanism of Candida albicans infection is revealed, involving a virulence factor called candidalysin (CL). CL damages cell membranes by forming membrane pores, and the formation mechanism involves pre-assembly of CL into polymers in solution, which then form the pores. A CL mutation, G4W, prevents polymer formation and pore formation. This research shows that CL polymerization is a necessary step for damaging cell membranes, and also provides a novel therapeutic target for treating candidiasis.

ELIFE (2022)

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Review Microbiology

Interactions between Candida albicans and the resident microbiota

Hao Li et al.

Summary: This review focuses on the interactions between Candida albicans and the host microbiota in the mouth, gut, blood, and vagina, and highlights important future research directions. Evaluating these interactions will contribute to a better understanding of the etiology of fungal infections and provide new insights for therapeutic approaches.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Cell Biology

High Presence of NETotic Cells and Neutrophil Extracellular Traps in Vaginal Discharges of Women with Vaginitis: An Exploratory Study

Fabiola Zambrano et al.

Summary: Infectious vaginitis is a significant syndrome that affects the health of millions of women worldwide. This study identified the presence of neutrophil extracellular traps (NETs) in vaginal discharges of women with bacterial vaginosis, candidiasis, and trichomoniasis and determined their concentration and phenotypes. It was found that different infections were associated with different NET phenotypes and an increased number of NETotic cells. These findings suggest that changes in the microbiota and the presence of fungal and parasitic infections play a role in the activation and induction of NETosis.

CELLS (2022)

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Review Food Science & Technology

Targeting Virulence Factors of Candida albicans with Natural Products

Qing-Ru Bu et al.

Summary: Natural products, particularly functional foods, offer potential in preventing and treating Candida albicans infections by targeting its virulence factors.

FOODS (2022)

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Article Microbiology

All-Trans Retinoic Acid Effect on Candida albicans Growth and Biofilm Formation

Enrico Salvatore Pistoia et al.

Summary: This study evaluated the effects of All-trans Retinoic Acid (ATRA) on Candida growth and biofilm formation. The results showed that ATRA inhibited fungal growth and negatively affected biofilm formation. It also induced plasma membrane damage in Candida cells.

JOURNAL OF FUNGI (2022)

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Article Biotechnology & Applied Microbiology

Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections

Monika Kumherova et al.

Summary: This study focused on isolating vaginal lactobacilli from pregnant women and testing their functional properties. The results showed that L. fermentum and L. rhamnosus exhibited high antibacterial activity, while L. crispatus, L. fermentum, and L. rhamnosus showed strong anti-Candida activity. These findings suggest that these lactobacillus strains may be used in probiotic products for the treatment and prevention of vulvovaginal infections in women.

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2021)

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Review Microbiology

Candida albicans biofilms and polymicrobial interactions

Nicole O. Ponde et al.

Summary: Candida albicans is a common fungus in the human microbiota that can form biofilms, which are difficult to eradicate and can lead to infections. Biofilm-associated infections present a major clinical challenge.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

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Article Infectious Diseases

Dysbiosis of the rat vagina is efficiently rescued by vaginal microbiota transplantation or probiotic combination

Tingtao Chen et al.

Summary: Vaginal dysbiosis, characterized by disturbed vaginal microbiota, is associated with gynaecological diseases, requiring effective therapeutic agents with VMT or probiotic combination showing promise in reducing inflammation and restoring microbiota balance to prevent recurrence.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

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Article Biotechnology & Applied Microbiology

Antibiofilm and antifungal activities of medium-chain fatty acids against Candida albicans via mimicking of the quorum-sensing molecule farnesol

Jin-Hyung Lee et al.

Summary: Medium-chain fatty acids were found to effectively inhibit hyphal growth and biofilm formation of Candida albicans, surpassing the inhibitory effects of farnesol.

MICROBIAL BIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Xionghui Ding et al.

Summary: The study demonstrates the important role of Gasdermin D in Candida's immune evasion, preventing the escape of the fungus from macrophages and improving survival rates in infected mice.

NATURE COMMUNICATIONS (2021)

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Review Microbiology

Immune Sensing of Candida albicans

Ebrima Bojang et al.

Summary: Infections caused by Candida albicans vary from superficial to systemic and are a major cause of nosocomial infections. The host environment plays a key role in modulating the host-pathogen interaction. Phagocytes play a crucial role in clearing C. albicans through PAMP-PRR interactions.

JOURNAL OF FUNGI (2021)

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Review Immunology

Contribution of Lactobacillus iners to Vaginal Health and Diseases: A Systematic Review

Nengneng Zheng et al.

Summary: Lactobacillus iners, first described in 1999, is a prevalent bacterial species of the vaginal microbiome. While it has probiotic characteristics, it can also contribute to vaginal dysbiosis under certain conditions, leading to diseases. Further studies are needed to fully understand its role in vaginal health and diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Microbiology

Leukotrienes Are Dispensable for Vaginal Neutrophil Recruitment as Part of the Immunopathological Response During Experimental Vulvovaginal Candidiasis

Junko Yano et al.

Summary: Despite some clinical evidence suggestive of off-target efficacy of leukotriene receptor antagonists (LTRAs) in recurrent vulvovaginal candidiasis (RVVC), leukotrienes and associated signaling pathways appear to be dispensable in the immunopathogenesis of vulvovaginal candidiasis (VVC) as shown in a mouse model study.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Lactobacillus iners Cell-Free Supernatant Enhances Biofilm Formation and Hyphal/Pseudohyphal Growth by Candida albicans Vaginal Isolates

Samuele Sabbatini et al.

Summary: The study found that Lactobacillus iners cell-free supernatant (CFS) significantly enhanced biofilm formation by Candida albicans clinical isolates, particularly those categorized as moderate or weak biofilm producers. This effect was associated with increased hyphal/pseudohyphal growth and upregulated expression levels of hyphae-associated genes HWP1 and ECE1. These results suggest a contributing role of L. iners in the pathogenesis of VVC and highlight the complexity of interactions between C. albicans and vaginal lactobacilli.

MICROORGANISMS (2021)

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Review Chemistry, Medicinal

Retinoids in Fungal Infections: From Bench to Bedside

Terenzio Cosio et al.

Summary: Retinoids, derived from vitamin A, have shown potent antimicrobial activity against a wide range of pathogens, including bacteria, fungi, and viruses. Although lacking double-blind clinical trials, current evidence supports the efficacy, tolerability, and safety profile of retinoids against localized and systemic fungal infections.

PHARMACEUTICALS (2021)

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Article Multidisciplinary Sciences

Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B

Jakub Suchodolski et al.

Summary: The study evaluated the effect of capric acid produced by probiotic yeast Saccharomyces boulardii on the activities of fluconazole and amphotericin B against pathogenic Candida albicans fungus. The results showed that capric acid may be a promising additive in combination with fluconazole, reducing efflux activity of multidrug resistance transporter Cdr1p. However, capric acid alone stimulated ergosterol production in C. albicans, leading to cross resistance towards amphotericin B. It is concluded that amphotericin B should not be administered with dietary supplements containing capric acid or S. boulardii cells.

SCIENTIFIC REPORTS (2021)

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Review Immunology

The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19?

Xiaofang Wang et al.

Summary: IL-36, a member of the interleukin 1 cytokine family, has been found to play crucial roles in inflammatory responses, infections, and diseases such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis. Research shows a growing interest in the potential implications of IL-36 for host protective immune responses against infections and new therapeutic strategies.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Microbiology

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

Marina Pekmezovic et al.

Summary: Vaginal candidiasis is caused by four phylogenetically diverse species, each exhibiting distinct pathogenicity patterns during infection of vaginal epithelial cells. Host cells respond uniformly to all species in the early stages of infection, but diverge in a species-dependent manner later on, driven primarily by species-specific mechanisms of epithelial damage.

NATURE MICROBIOLOGY (2021)

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Article Microbiology

Study of the Vaginal Microbiota in Healthy Women of Reproductive Age

Melanie C. Alonzo Martinez et al.

Summary: This study investigated the vaginal microbiota of premenopausal women and found specific microbial community types in different menstrual phases, with Lactobacillus crispatus being the predominant species. 75% of patients showed resistance to changes in their vaginal microbiota even between consecutive menstrual cycles.

MICROORGANISMS (2021)

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Article Immunology

Characterization of vaginal fungal communities in healthy women and women with bacterial vaginosis (BV); a pilot study

Liisa Lehtoranta et al.

Summary: The study characterized the vaginal mycobiota in healthy women and those with BV infection, finding a diverse range of yeast and filamentous fungi species with Candida as the dominant genus. The abundance of C. albicans was inversely correlated with fungal diversity and oral metronidazole treatment did not significantly impact its relative abundance. The results underscore the importance of further exploring the diversity of the fungal community in both healthy and BV-infected women.

MICROBIAL PATHOGENESIS (2021)

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Article Microbiology

A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis

Junyan Liu et al.

Summary: Vulvovaginal candidiasis caused by Candida albicans poses significant issues for women globally. A conserved variant candidalysin isoform was identified across clinical isolates, with reduced virulence associated with impaired secretion. This study presents a novel mechanism for attenuating C. albicans virulence at the ECE1 locus.

PLOS PATHOGENS (2021)

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Review Microbiology

It Takes Two to Tango: How a Dysregulation of the Innate Immunity, Coupled With Candida Virulence, Triggers VVC Onset

Andrea Ardizzoni et al.

Summary: Vulvovaginal candidiasis (VVC) is mainly caused by C. albicans, with other species also playing a role in recurrent forms of the disease. Host immune responses, including neutrophil recruitment and interactions with fungal factors, contribute to the pathogenesis of VVC. The vaginal microbiome and specific antibodies have been implicated in VVC development.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Microbiology

Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

Yiwen Han et al.

Summary: Vaginal microbiota dysbiosis plays a significant role in gynecological infectious and non-infectious diseases, and intervention on microbiota composition is crucial for the treatment of gynecological diseases.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Recurrent Vulvovaginal Candidiasis: a Dynamic Interkingdom Biofilm Disease of Candida and Lactobacillus

Emily McKloud et al.

Summary: This study identified changes in vaginal microbiome in RVVC, showing a reduction in Lactobacillus crispatus and an increase in Lactobacillus iners. The presence of Candida albicans biofilm formation and interactions with Lactobacillus species were also highlighted, suggesting potential mechanisms for RVVC and the importance of understanding these interactions for developing effective therapies.

MSYSTEMS (2021)

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Review Dentistry, Oral Surgery & Medicine

Anticandidal Activities by Lactobacillus Species: An Update on Mechanisms of Action

Roberto Vazquez-Munoz et al.

Summary: Lactobacilli, as probiotics, can provide various benefits to the host, including antifungal effects that can help prevent Candida infections. The mechanisms of action of Lactobacillus spp. against Candida remain largely unexplored, and this work aims to comprehensively review and update current knowledge on these mechanisms.

FRONTIERS IN ORAL HEALTH (2021)

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Review Microbiology

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

Christophe d'Enfert et al.

Summary: Candida albicans is a major fungal pathogen of humans that can lead to mucosal infections and life-threatening systemic infections. The interactions between fungus, host, and microbiota play a key role in disease development, and understanding these variables could lead to targeted antifungal therapies for vulnerable patients.

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Associations between the vaginal microbiome and Candida colonization in women of reproductive age

Brett A. Tortelli et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

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Article Microbiology

Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome

David J. Lowes et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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The Interleukin (IL) 17R/IL-22R Signaling Axis Is Dispensable for Vulvovaginal Candidiasis Regardless of Estrogen Status

Brian M. Peters et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Nutrition & Dietetics

Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis

Antonio Barrientos-Duran et al.

NUTRIENTS (2020)

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Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa

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GUT MICROBES (2020)

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Review Microbiology

Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review

Namarta Kalia et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2020)

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Review Immunology

New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond

Aize Pellon et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Saccharomyces cerevisiae-Based Probiotics as Novel Antimicrobial Agents to Prevent and Treat Vaginal Infections

Roberta Gaziano et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Materials Science, Biomaterials

Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches Inhibit Candida albicans Growth and Reduce the Biofilm Viability

Katharina H. Clitherow et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Mechanism of Candida pathogenesis: revisiting the vital drivers

Ifeanyi Elibe Mba et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

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Article Microbiology

Biofilm Formation ofCandida albicansFacilitates Fungal Infiltration and Persister Cell Formation in Vaginal Candidiasis

Xueqing Wu et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Microbiology

Clinical Candida albicans Vaginal Isolates and a Laboratory Strain Show Divergent Behaviors during Macrophage Interactions

Franziska Gerwien et al.

MSPHERE (2020)

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Article Nutrition & Dietetics

Recovery ofSaccharomyces cerevisiaeCNCM I-3856 in Vaginal Samples of Healthy Women after Oral Administration

Amelie Decherf et al.

NUTRIENTS (2020)

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Article Pharmacology & Pharmacy

Predictive role of vitamin A serum concentration in psoriatic patients treated with IL-17 inhibitors to prevent skin and systemic fungal infections

Campione Elena et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2020)

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Article Microbiology

Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (pANCA) Impair Neutrophil Candidacidal Activity and Are Increased in the Cellular Fraction of Vaginal Samples from Women with Vulvovaginal Candidiasis

Andrea Ardizzoni et al.

JOURNAL OF FUNGI (2020)

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Article Microbiology

Some like it hot: Candida activation of inflammasomes

Giorgio Camilli et al.

PLOS PATHOGENS (2020)

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Review Microbiology

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

Carmen Rodriguez-Cerdeira et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

Wallace Jeng Yang Chee et al.

MICROBIAL CELL FACTORIES (2020)

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Mihai G. Netea et al.

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Characterization of Microbiota in Endometrial Fluid and Vaginal Secretions in Infertile Women with Repeated Implantation Failure

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Article Microbiology

Local Probiotic Lactobacillus crispatus and Lactobacillus delbrueckii Exhibit Strong Antifunga Effects Against Vulvovaginal Candidiasis in a Rat Model

Ting Li et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Article Immunology

Vaginal Epithelial Cells Discriminate Between Yeast and Hyphae of Candida albicans in Women Who Are Colonized or Have Vaginal Candidiasis

Elena Roselletti et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

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Article Multidisciplinary Sciences

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

Jemima Ho et al.

NATURE COMMUNICATIONS (2019)

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Review Infectious Diseases

Contribution of Epithelial Cells to Defense Mechanisms in the Human Vagina

Iara M. Linhares et al.

CURRENT INFECTIOUS DISEASE REPORTS (2019)

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Review Microbiology

Candida albicans Interactions with Mucosal Surfaces during Health and Disease

Spyridoula-Angeliki Nikou et al.

PATHOGENS (2019)

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Article Biochemistry & Molecular Biology

Vaginal microbiome transplantation in women with intractable bacterial vaginosis

Ahinoam Lev-Sagie et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Diversity of vaginal microbiome and metabolome during genital infections

Camilla Ceccarani et al.

SCIENTIFIC REPORTS (2019)

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Article Microbiology

Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2

Sheng-Yang Wu et al.

PLOS PATHOGENS (2019)

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Article Microbiology

A Role for Yeast/Pseudohyphal Cells of Candida albicans in the Correlated Expression of NLRP3 Inflammasome Inducers in Women With Acute Vulvovaginal Candidiasis

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Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk

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Candidalysin: discovery and function in Candida albicans infections

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CURRENT OPINION IN MICROBIOLOGY (2019)

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Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae

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Effect of Acetic Acid and Lactic Acid at Low pH in Growth and Azole Resistance of Candida albicans and Candida glabrata

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Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond

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The Case for an Expanded Concept of Trained Immunity

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Saccharomyces cerevisiae-based probiotic as novel anti-fungal and anti-inflammatory agent for therapy of vaginal candidiasis

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Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

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The implausible in vivo role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota

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MICROBIOME (2018)

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Comparative Analysis of the Capacity of the Candida Species To Elicit Vaginal lmmunopathology

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INFECTION AND IMMUNITY (2018)

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Global burden of recurrent vulvovaginal candidiasis: a systematic review

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Epitope unmasking in vulvovaginal candidiasis is associated with hyphal growth and neutrophilic infiltration

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The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

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Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages

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Novel Mechanism behind the Immunopathogenesis of Vulvovaginal Candidiasis: Neutrophil Anergy

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Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa

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Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition

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Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis

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Candida albicans Mycofilms Support Staphylococcus aureus Colonization and Enhances Miconazole Resistance in Dual-Species Interactions

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Innate Immunity to Mucosal Candida Infections

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Candida albicans-epithelial interactions and induction of mucosal innate immunity

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Biofilms Formed by Isolates from Recurrent Vulvovaginal Candidiasis Patients Are Heterogeneous and Insensitive to Fluconazole

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Lactobacillus crispatus Modulates Vaginal Epithelial Cell Innate Response to Candida albicans

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REGENERATIVE BIOMATERIALS (2017)

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CRITICAL REVIEWS IN MICROBIOLOGY (2016)

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Quercetin Assists Fluconazole to Inhibit Biofilm Formations of Fluconazole-Resistant Candida Albicans in In Vitro and In Vivo Antifungal Managements of Vulvovaginal Candidiasis

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Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC

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Candidalysin is a fungal peptide toxin critical for mucosal infection

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Integrating Inflammasome Signaling in Sexually Transmitted Infections

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Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

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In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans

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Innate immune cell response upon Candida albicans infection

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IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells

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Autophagy and Reactive Oxygen Species Are Involved in Neutrophil Extracellular Traps Release Induced by C-albicans Morphotypes

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Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping

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Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra

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Biofilms: An Underappreciated Mechanism of Treatment Failure and Recurrence in Vaginal Infections

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Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

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Transcriptomic Analysis of Vulvovaginal Candidiasis Identifies a Role for the NLRP3 Inflammasome

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MBIO (2015)

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Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice

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The role of pattern recognition receptors in the innate recognition of Candida albicans

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VIRULENCE (2015)

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Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface

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Extracellular Enzymes and Susceptibility to Fluconazole in Candida Strains Isolated From Patients With Vaginitis and Healthy Individuals

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CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

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Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity

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Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity

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BMC MICROBIOLOGY (2014)

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Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages

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EUKARYOTIC CELL (2014)

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Vaginal Epithelial Cell-Derived S100 Alarmins Induced by Candida albicans via Pattern Recognition Receptor Interactions Are Sufficient but Not Necessary for the Acute Neutrophil Response during Experimental Vaginal Candidiasis

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SCIENCE (2014)

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Candida Vaginitis: When Opportunism Knocks, the Host Responds

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PLOS PATHOGENS (2014)

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Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis

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FRONTIERS IN MICROBIOLOGY (2014)

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Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome

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Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

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Characterization of the Vaginal Micro- and Mycobiome in Asymptomatic Reproductive-Age Estonian Women

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Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

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Altered Dynamics of Candida albicans Phagocytosis by Macrophages and PMNs When Both Phagocyte Subsets Are Present

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Influence of Vaginal Bacteria and D- and L-Lactic Acid Isomers on Vaginal Extracellular Matrix Metalloproteinase Inducer: Implications for Protection against Upper Genital Tract Infections

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Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis

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Immunity to infection in IL-17-deficient mice and humans

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Interplay between Candida albicans and the Mammalian Innate Host Defense

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INFECTION AND IMMUNITY (2012)

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Human genetic susceptibility to Candida infections

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MEDICAL MYCOLOGY (2012)

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The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway

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EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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A virosomal vaccine against candidal vaginitis: Immunogenicity, efficacy and safety profile in animal models

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VACCINE (2012)

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In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide

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BMC INFECTIOUS DISEASES (2011)

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Trained Immunity: A Memory for Innate Host Defense

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Candida albicans Als3, a Multifunctional Adhesin and Invasin

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EUKARYOTIC CELL (2011)

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Inerolysin, a Cholesterol-Dependent Cytolysin Produced by Lactobacillus iners

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Th17 Cells and IL-17 in Protective Immunity to Vaginal Candidiasis

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PLOS ONE (2011)

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Candida albicans Yeast and Hyphae are Discriminated by MAPK Signaling in Vaginal Epithelial Cells

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PLOS ONE (2011)

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Vaginal microbiome of reproductive-age women

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis

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BMC GENOMICS (2010)

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Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli

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A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

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Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

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Candida albicans β-Glucan Exposure Is Controlled by the Fungal CEK1-Mediated Mitogen-Activated Protein Kinase Pathway That Modulates Immune Responses Triggered through Dectin-1

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INFECTION AND IMMUNITY (2010)

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(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

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Candida albicans Dampens Host Defense by Downregulating IL-17 Production

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JOURNAL OF IMMUNOLOGY (2010)

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Biofilm formation on intrauterine devices in patients with recurrent vulvovaginal candidiasis

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MEDICAL MYCOLOGY (2010)

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Candida albicans forms biofilms on the vaginal mucosa

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MICROBIOLOGY-SGM (2010)

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Capric Acid Secreted by S. boulardii Inhibits C. albicans Filamentous Growth, Adhesion and Biofilm Formation

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Vaginal Microbiota of Women with Frequent Vulvovaginal Candidiasis

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INFECTION AND IMMUNITY (2009)

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The yeast Candida albicans evades human complement attack by secretion of aspartic proteases

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MOLECULAR IMMUNOLOGY (2009)

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Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

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Host-microbe interactions: innate pattern recognition of fungal pathogens

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CURRENT OPINION IN MICROBIOLOGY (2008)

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Hemocidins in a functional and structural context of human antimicrobial peptides

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FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

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Novel stress responses facilitate Saccharomyces cerevisiae growth in the presence of the monocarboxylate preservatives

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Dynamic, Morphotype-Specific Candida albicans beta-Glucan Exposure during Infection and Drug Treatment

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PLOS PATHOGENS (2008)

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The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

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Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

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JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2007)

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Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells

Quynh T. Phan et al.

PLOS BIOLOGY (2007)

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Function of Candida albicans adhesin Hwp1 in biofilm formation

Clarissa J. Nobile et al.

EUKARYOTIC CELL (2006)

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Review Infectious Diseases

Probiotics for prevention of recurrent vulvovaginal candidiasis: a review

Matthew E. Falagas et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)

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The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose

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GLYCOBIOLOGY (2006)

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Biofilm formation on intrauterine devices in relation to duration of use

Z Pál et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2005)

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Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis

M Schaller et al.

INFECTION AND IMMUNITY (2005)

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Article Obstetrics & Gynecology

Characterization of Toll-like receptors in the female reproductive tract in humans

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HUMAN REPRODUCTION (2005)

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Comparison between Candida albicans agglutinin-like sequence gene expression patterns in human clinical specimens and models of vaginal candidiasis

G Cheng et al.

INFECTION AND IMMUNITY (2005)

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RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms

CB Green et al.

MICROBIOLOGY-SGM (2004)

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Zafirlukast for severe recurrent vulvovaginal candidiasis: an open label pilot study

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SEXUALLY TRANSMITTED INFECTIONS (2004)

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Antibacterial hemoglobin peptides in human menstrual blood

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PEPTIDES (2004)

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Candida albicans secreted aspartyl proteinases in virulence and pathogenesis

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MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2003)

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Vulvovaginal carriage of yeasts other than Candida albicans

J Holland et al.

SEXUALLY TRANSMITTED INFECTIONS (2003)

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In vitro killing of Candida albicans by fatty acids and monoglycerides

G Bergsson et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)

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Review Immunology

Role played by lactobacilli in controlling the population of vaginal pathogens

S Boris et al.

MICROBES AND INFECTION (2000)

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