Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review

Periodontal diseases and dental caries are the most common infectious oral diseases impacting oral health globally. Oral cavity health is crucial for enhancing life quality since it serves as the entranceway to general health. The oral microbiome and oral infectious diseases are strongly correlated. Gram-negative anaerobic bacteria have been associated with periodontal diseases. Due to the shortcomings of several antimicrobial medications frequently applied in dentistry, the lack of resources in developing countries, the prevalence of oral inflammatory conditions, and the rise in bacterial antibiotic resistance, there is a need for reliable, efficient, and affordable alternative solutions for the prevention and treatment of periodontal diseases. Several accessible chemical agents can alter the oral microbiota, although these substances also have unfavorable symptoms such as vomiting, diarrhea, and tooth discoloration. Natural phytochemicals generated from plants that have historically been used as medicines are categorized as prospective alternatives due to the ongoing quest for substitute products. This review concentrated on phytochemicals or herbal extracts that impact periodontal diseases by decreasing the formation of dental biofilms and plaques, preventing the proliferation of oral pathogens, and inhibiting bacterial adhesion to surfaces. Investigations examining the effectiveness and safety of plant-based medicines have also been presented, including those conducted over the past decade.

Automated summary

Periodontal diseases and dental caries are common infectious oral diseases globally, affecting oral health. The oral microbiome and oral infectious diseases are strongly correlated. Gram-negative anaerobic bacteria are associated with periodontal diseases. Due to several limitations in antimicrobial medications, lack of resources, prevalence of oral inflammatory conditions, and antibiotic resistance, alternative solutions for periodontal diseases are needed. Natural phytochemicals from plants offer potential alternatives. This review focuses on phytochemicals or herbal extracts that impact periodontal diseases by reducing biofilms and plaques, inhibiting oral pathogens, and preventing bacterial adhesion.