Antimicrobial Efficiency of Pistacia lentiscus L. Derivates against Oral Biofilm-Associated Diseases-A Narrative Review

Pistacia lentiscus L. (PlL) has been used for centuries in traditional medicine. The richness in antimicrobial biomolecules of Pll derivates can represent an alternative to chemically formulated agents used against oral infections. This review summarizes the knowledge on the antimicrobial activity of PlL essential oil (EO), extracts, and mastic resin against microorganisms being of relevance in oral biofilm-associated diseases. Results demonstrated that the potential of PlL polyphenol extracts has led to increasing scientific interest. In fact, the extracts are a significantly more effective agent than the other PlL derivates. The positive findings regarding the inhibition of periodontal pathogens and C. albicans, together with the antioxidant activity and the reduction of the inflammatory responses, suggest the use of the extracts in the prevention and/or reversal of intraoral dysbiosis. Toothpaste, mouthwashes, and local delivery devices could be effective in the clinical management of these oral diseases.

Automated summary

Pistacia lentiscus L. (PlL) has a long history of use in traditional medicine and its antimicrobial properties make it a potential alternative for oral infections. This review highlights the effectiveness of PlL polyphenol extracts in inhibiting periodontal pathogens and C. albicans, reducing inflammation, and preventing intraoral dysbiosis. The use of these extracts in toothpaste, mouthwashes, and local delivery devices could be beneficial for clinical management of oral diseases.