☆ 4.6 Article

Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in US Military Treatment Facilities

MICROBIOLOGY SPECTRUM (2023)

Complete genome of the extensively antibiotic-resistant GC1 Acinetobacter baumannii isolate MRSN 56 reveals a novel route to fluoroquinolone resistance

Christopher J. Harmer et al.

Summary: This study examines the causes of antibiotic resistance in the extensively resistant global clone 1 (GC1) Acinetobacter baumannii isolate MRSN 56. The study identified acquired resistance genes at different locations in the chromosome and discovered a new sublineage of GC1 lineage 1 with novel features. The involvement of the mar operon in fluoroquinolone resistance was also noted for the first time.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

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Article Microbiology

Mechanisms of IS26-Mediated Amplification of the aphA1 Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate

Christopher J. Harmer et al.

Summary: This study reveals the direct involvement of IS26 in the amplification of the aphA1 gene and shows that amplification of the aphA1 gene can lead to resistance to tobramycin. This has important implications for understanding the mechanism of heteroresistance and treatment failure.

MICROBIOLOGY SPECTRUM (2022)

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Article Microbiology