4.6 Article

Comparative Activities of Novel Therapeutic Agents against Molecularly Characterized Clinical Carbapenem-Resistant Enterobacterales Isolates

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Emergence of 16S rRNA methyltransferases among carbapenemase-producing Enterobacterales in Spain studied by whole-genome sequencing

Jorge Arca-Suarez et al.

Summary: This study investigated the prevalence, resistance mechanisms, molecular epidemiology, and genetic support of 16S rRNA methyltransferases (RMTs) in carbapenemase-producing Enterobacterales (CPE) isolates from Spain. The findings show an emerging trend of RMTs among clinical CPE isolates, posing a threat to the clinical utility of aminoglycosides and plazomicin.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2022)

Article Immunology

Infectious Diseases Society of America 2022 Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa)

Pranita D. Tamma et al.

Summary: This article provides updated guidance on the treatment of infections caused by ESBL-E, CRE, and DTR-P. aeruginosa. The guidance was developed by a panel of infectious diseases specialists and includes preferred and alternative treatment recommendations. The document emphasizes the importance of consulting with an infectious diseases specialist for the treatment of antimicrobial-resistant infections.

CLINICAL INFECTIOUS DISEASES (2022)

Article Microbiology

Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae from a Major Public Health Hospital in Singapore

Jocelyn Qi-Min Teo et al.

Summary: In this study, carbapenem-resistant Klebsiella pneumoniae clinical isolates collected from the largest public acute-care hospital in Singapore over a 12-year period were characterized using whole-genome sequencing. The study revealed significant genomic diversity, with the presence of both epidemic, multidrug-resistant clones and diverse nonepidemic lineages.

MICROBIOLOGY SPECTRUM (2022)

Article Microbiology

Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible Pseudomonas aeruginosa

Jocelyn Qi-Min Teo et al.

Summary: This study analyzed 195 carbapenem-nonsusceptible Pseudomonas aeruginosa clinical isolates recovered in Singapore from 2009 to 2020, and found that resistance to ceftolozane/tazobactam was mainly mediated by beta-lactamases, especially metallo-beta-lactamases. The high resistance to C/T highlights its limited utility as an empirical agent in the region.

MSPHERE (2021)

Review Infectious Diseases

Continuous Evolution: Perspective on the Epidemiology of Carbapenemase Resistance Among Enterobacterales and Other Gram-Negative Bacteria

Glen T. Hansen

Summary: Carbapenems are antibiotics used to treat Gram-negative bacteria infections, but carbapenem-resistant Enterobacterales (CRE) have emerged globally, posing a significant public health issue. Different types of carbapenemase enzymes are spreading rapidly, requiring active surveillance and therapeutic strategies.

INFECTIOUS DISEASES AND THERAPY (2021)

Article Infectious Diseases

Activity of ceftazidime/avibactam, meropenem/vaborbactam and imipenem/relebactam against carbapenemase-negative carbapenem-resistant Enterobacterales isolates from US hospitals

Mariana Castanheira et al.

Summary: Research on carbapenem-resistant Enterobacterales (CRE) without carbapenemase genes revealed complex resistance mechanisms, limited activity of most beta-lactam agents, and effective inhibition by ceftazidime/avibactam. Further studies are needed to understand the diverse resistance mechanisms and optimize treatment strategies for these isolates.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Article Immunology

Genomic characterization of carbapenem-non-susceptible Pseudomonas aeruginosa in Singapore

Jocelyn Qi-Min Teo et al.

Summary: Pseudomonas aeruginosa is a clinically important pathogen known for its broad-spectrum resistance, and whole-genome sequencing-based genomic surveillance is limited in the Southeast Asian region. In this study, 222 carbapenem-non-susceptible P. aeruginosa isolates from a Singapore hospital showed broad-spectrum resistance, with 51.4% of isolates producing carbapenemases, mainly IMP and NDM metallo-beta-lactamases.

EMERGING MICROBES & INFECTIONS (2021)

Review Immunology

Resistance to Novel β-Lactam-β-Lactamase Inhibitor Combinations The Price of Progress

Krisztina M. Papp-Wallace et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2020)

Article Infectious Diseases

A Real-World Assessment of Clinical Outcomes and Safety of Eravacycline: A Novel Fluorocycline

Nicholas Van Hise et al.

INFECTIOUS DISEASES AND THERAPY (2020)

Review Pharmacology & Pharmacy

Eravacycline: The Tetracyclines Strike Back

Maria Heaney et al.

ANNALS OF PHARMACOTHERAPY (2019)

Review Chemistry, Medicinal

Nonlinear Protein Binding: Not What You Think

Amelia N. Deitchman et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Article Infectious Diseases

A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding

Ravi Shankar Prasad Singh et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2017)