期刊
JOURNAL OF PHARMACEUTICAL ANALYSIS
卷 13, 期 9, 页码 960-967出版社
ELSEVIER
DOI: 10.1016/j.jpha.2023.06.001
关键词
Nanomedicine; Clinical studies; Gold nanoparticles; Safety; Applications
The use of gold nanoparticles in medicine has vast clinical implications and exciting therapeutic potential. Current studies suggest that there are no major safety concerns with the use of gold nanoparticles, but more research and clinical trials are needed to further understand their safety and efficacy in clinical settings.
Use of gold nanoparticles (GNPs) in medicine is an emerging field of translational research with vast clinical implications and exciting therapeutic potential. However, the safety of using GNPs in human subjects is an important question that remains unanswered. This study reviews over 20 clinical trials focused on GNP safety and aims to summarize all the clinical studies, completed and ongoing, to identify whether GNPs are safe to use in humans as a therapeutic platform. In these studies, GNPs were implemented as drug delivery devices, for photothermal therapy, and utilized for their intrinsic therapeutic effects by various routes of delivery. These studies revealed no major safety concerns with the use of GNPs; however, the number of trials and total patient number remains limited. Multi-dose, multicenter blinded trials are required to deepen our understanding of the use of GNPs in clinical settings to facilitate translation of this novel, multifaceted therapeutic device. Expanding clinical trials will require collaboration between clinicians, scientists, and biotechnology companies. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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