4.7 Review

Antioxidant Supplementation on Male Fertility-A Systematic Review

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Summary: Recent evidence suggests that reductive stress, in addition to oxidative stress, plays a role in diseases such as male infertility. Excessive accumulation of reductants can lead to damaging mechanisms and the generation of ROS. Limited studies have been conducted on reductive stress, therefore antioxidant therapy remains a central approach in treating male infertility.

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Summary: Male infertility is a common medical condition affecting approximately 15% of couples globally, with an estimated 190 million people struggling with it. Urologists face a wide range of male infertility conditions, from typical cases to more complex ones, with oxidative stress being a critical component entailing an imbalance between ROS and antioxidants. The antioxidant paradox poses one of the biggest challenges in andrology, with the emergence of new tools like the MiOXSYS (R) assay offering a quantification of OS and potential solutions for maintaining redox balance.

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