☆ 4.7 Review

The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae

ANTIOXIDANTS (2023)

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Review Food Science & Technology

Nutrients and bioactives in citrus fruits: Different citrus varieties, fruit parts, and growth stages

Xingmiao Lu et al.

Summary: Citrus fruits are consumed worldwide due to their attractive aromas, taste, high nutritional values, and various health benefits. They are rich in nutrients and bioactives that protect against various diseases and have potential health benefits. The composition and content of these compounds vary among different citrus varieties, fruit parts, and growth stages.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Review Plant Sciences

Chemistry, Occurrence, Properties, Applications, and Encapsulation of Carotenoids-A Review

Marco Antonio Gonzalez-Pena et al.

Summary: Carotenoids are natural lipophilic pigments and antioxidants found in many fruits and vegetables. They have positive health effects and can decrease the risk of chronic diseases. However, due to their chemical instability and poor solubility, their use in the food industry is limited. Encapsulation techniques are employed to overcome these issues.

PLANTS-BASEL (2023)

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Article Biochemistry & Molecular Biology

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals

Uladzimir Barayeu et al.

Summary: Ferroptosis is a type of cell death caused by radical-driven lipid peroxidation. Our study shows that sulfane sulfur species, particularly hydropersulfides, scavenge free radicals and suppress ferroptosis. Cysteine can support ferroptosis resistance independently of the GPX4 pathway by providing sulfur for S-0 biosynthesis.

NATURE CHEMICAL BIOLOGY (2023)

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Review Food Science & Technology

Citrus flavonoids and their antioxidant evaluation

Yue Wang et al.

Summary: This review summarizes the biosynthesis, composition, and distribution of citrus flavonoids, and compares the detection methods of their antioxidant capacity. It also discusses the antioxidant functions of citrus flavonoids under different evaluation systems and their regulatory mechanisms. Additionally, the review points out some shortcomings in current research and provides suggestions for further studies.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Review Physiology

Benefits of a plant-based diet and considerations for the athlete

Keely A. Shaw et al.

Summary: Individuals may choose a plant-based diet for various reasons, including religious practices, health benefits, and concerns for animal and environmental welfare. Plant-based diets offer a wide range of health benefits and may enhance exercise performance. However, careful planning is required to ensure adequate intake and absorption of energy and essential nutrients.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management

Qing Jiang et al.

Summary: Studies have shown that gamma T has unique antioxidant and anti-inflammatory activities compared to alpha T, providing superior protection for mitochondrial function.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly

Petra A. Tsuji et al.

Summary: Selenium is an essential element in the diet and has many health benefits, such as preventing heart disease and cancer, supporting male reproduction, and boosting the immune system. It plays important roles in the molecular biology of organisms and its incorporation into proteins is a unique feature. Research has focused on selenium's role in cancer prevention and its potential involvement in various diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Anthocyanins: Traditional Uses, Structural and Functional Variations, Approaches to Increase Yields and Products' Quality, Hepatoprotection, Liver Longevity, and Commercial Products

Hamdoon A. Mohammed et al.

Summary: Anthocyanins, water-soluble colored compounds of the flavonoid class, are abundantly found in various parts of plants. They have been widely used for liver protection and as antioxidants, exhibiting various biological activities. The extraction and production methods of anthocyanin-based products are of great economic importance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

Improving the anti-ageing activity of coenzyme Q10 through protransfersome-loaded emulgel

Qurrota Ayunin et al.

Summary: This study evaluates the use of a protransfersomal emulgel to improve the delivery and stability of CoQ10 in the skin. The results show that the Protransf-CoQ10 emulgel successfully delivers CoQ10 and increases collagen density and fibroblast cell count, indicating its potential for repairing skin ageing.

SCIENTIFIC REPORTS (2022)

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Article Green & Sustainable Science & Technology

Monitoring of Butylated Hydroxyanisole in Food and Wastewater Samples Using Electroanalytical Two-Fold Amplified Sensor

Zahra Arab et al.

Summary: The newly fabricated sensor showed excellent performance in monitoring BHA in water and food samples, with outstanding catalytic activity and enhanced oxidation current, and acceptable recovery data.

SUSTAINABILITY (2022)

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Article Pharmacology & Pharmacy

Decylubiquinone Inhibits Colorectal Cancer Growth Through Upregulating Sirtuin2

Jinlian Li et al.

Summary: The study found that Decylubiquinone (DUb) can inhibit the growth and metastasis of colorectal cancer (CRC), and it suppresses CRC progression by upregulating SIRT2.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Immunology

Effects of Selenium as a Dietary Source on Performance, Inflammation, Cell Damage, and Reproduction of Livestock Induced by Heat Stress: A Review

Yuhui Zheng et al.

Summary: Heat stress resulting from global warming is harmful to livestock and has become an urgent issue in animal husbandry worldwide. Ruminants, growing pigs, and poultry are highly susceptible to heat stress due to their fast growth, high metabolism, high production levels, and sensitivity to temperature. Dietary selenium supplementation has been confirmed to improve gastrointestinal health, production performance, and reproductive physiology under heat stress conditions. The mechanisms involve the regulation of nutrient digestibility, antioxidant status, and immunocompetence.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Role of Sulphur and Heavier Chalcogens on the Antioxidant Power and Bioactivity of Natural Phenolic Compounds

Maria Laura Alfieri et al.

Summary: The activity of natural phenols is primarily associated with their antioxidant potential and is expressed in various biological effects. Molecular scaffold manipulation of these compounds is a sought-after approach to enhance or modulate their properties. The insertion of S/Se/Te containing substituents on phenols can increase/decrease their H-donor/acceptor ability through electronic and stereo-electronic effects. Some phenols with chalcogen substitutions exhibit better antioxidant activity than their natural counterparts.

BIOMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Recent Progress in Antioxidant Active Substances from Marine Biota

Todorka Vladkova et al.

Summary: This review provides an update on the current status and new developments of marine-biota-derived antioxidants, including new sources, substances, and derivation methods. Natural substances with antioxidant and antimicrobial properties are of particular interest. Byproducts and wastes serve as valuable sources of antioxidants. Optimized non-conventional derivation methods are expected to enhance production and improve the quality of the derived substances.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

May Nasser Bin-Jumah et al.

Summary: Lycopene, a bioactive red pigment found in plants, has been shown to have positive effects on human health, including preventing chronic diseases such as diabetes and cardiovascular diseases. It acts as an antioxidant, lowers blood pressure, and improves lipid levels, thus protecting against coronary artery disease and hypertension.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Chemical Stability of Ascorbic Acid Integrated into Commercial Products: A Review on Bioactivity and Delivery Technology

Xin Yin et al.

Summary: The L-enantiomer of ascorbic acid, also known as vitamin C, is essential for maintaining physiological processes in humans and animals. The lack of a key enzyme for de novo synthesis of ascorbic acid in some mammals, including humans, has led to the fortification of foods with this vitamin. Understanding the degradation of ascorbic acid in the food matrix and its interaction with coexisting components is crucial for its stability and delivery to the active site.

ANTIOXIDANTS (2022)

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Editorial Material Nutrition & Dietetics

Editorial: Selenium, Human Health and Chronic Disease

Barbara R. Cardoso et al.

FRONTIERS IN NUTRITION (2022)

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Article Hematology

Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease

Archita Venugopal Menon et al.

Summary: This study identified ferroptosis as a key mechanism of cardiomyopathy in sickle cell disease (SCD). SCD causes heme overload, leading to cardiovascular complications. Increased heme upregulates heme oxygenase 1 (Hmox1), which drives cardiomyopathy through ferroptosis. Inhibiting or inducing Hmox1 regulates the severity of cardiac damage.

BLOOD (2022)

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Article Chemistry, Multidisciplinary

A comparison of cell death mechanisms of antioxidants, butylated hydroxyanisole and butylated hydroxytoluene

Mizuki Mizobuchi et al.

Summary: The study investigated the cytotoxic effects of BHA and differences in cell death mechanism for BHA and BHT in rat thymocytes. The results showed that BHA induced apoptosis, while BHT induced non-apoptotic cell death in rat thymocytes.

DRUG AND CHEMICAL TOXICOLOGY (2022)

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Review Biochemistry & Molecular Biology

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Dmitry Osmakov et al.

Summary: This review provides an up-to-date overview of the current research progress on the mechanisms of action, pharmacological effects, and chemical synthesis methods of lignans in diseases associated with oxidative stress and inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, Research & Experimental

Divergent effects of HIV reverse transcriptase inhibitors on pancreatic beta-cell function and survival: Potential role of oxidative stress and mitochondrial dysfunction

Soulef Chahinez Maandi et al.

Summary: Antiretroviral therapy (ART) in HIV/AIDS treatment is crucial but has been associated with an increased risk of type 2 diabetes mellitus (T2DM). This study found that the non-nucleoside reverse transcriptase inhibitors efavirenz and rilpivirine have damaging effects on beta-cell function and survival, potentially mediated by oxidative stress and mitochondrial toxicity. In contrast, the nucleoside reverse transcriptase inhibitors tenofovir disoproxil fumarate and emtricitabine did not affect beta-cell function and survival.

LIFE SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity

Olga Babich et al.

Summary: This review explores the possibility of using natural plant compounds with antioxidant, anti-inflammatory, anti-glycation, and anti-neurodegenerative properties to slow down the onset of age-related changes. Herbal preparations play an essential role in preventing and treating neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

MOLECULES (2022)

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Review Biochemistry & Molecular Biology

Dietary Polyphenols: Extraction, Identification, Bioavailability, and Role for Prevention and Treatment of Colorectal and Prostate Cancers

Naveed Ahmad et al.

Summary: Polyphenols in fruits, vegetables, and other plants have health benefits and potential for treating and preventing diseases, especially cancer. The study focuses on the extraction methods of polyphenols and their role in preventing and treating colorectal and prostate cancers.

MOLECULES (2022)

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Article Acoustics

Green extraction of lutein from marigold flower petals, process optimization and its potential to improve the oxidative stability of sunflower oil

Shaziya Manzoor et al.

Summary: Marigold flower petals are a rich source of lutein, which can be extracted using ultrasound-assisted extraction to improve the stability of sunflower oil. The extracted lutein showed good antioxidant activity and effectively improved the oxidative stability of sunflower oil.

ULTRASONICS SONOCHEMISTRY (2022)

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Article Nutrition & Dietetics

Essential Elements and Isoflavonoids in the Prevention of Prostate Cancer

Iwona J. Stanislawska et al.

Summary: The intake of selected minerals, especially zinc, calcium and selenium, and high consumption of dietary isoflavones are recognized as factors influencing prostate cancer risk. This study examined the combined effects of dietary isoflavonoids and minerals on prostate cancer cells proliferation and genotoxicity. The results suggest that the minerals have minimal influence on the anti-proliferative activity of isoflavonoids but significantly modulate their anti-genotoxic effects.

NUTRIENTS (2022)

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Article Polymer Science

Synthesis and In Vitro Characterization of Ascorbyl Palmitate-Loaded Solid Lipid Nanoparticles

Maja Ledinski et al.

Summary: Research on solid lipid nanoparticles (SLN) loaded with ascorbyl palmitate for anti-tumor applications found that the formulation with 3% Pluronic F-68 showed better selectivity for targeting tumor cells at lower concentrations, and antioxidative effects were observed within 1 hour.

POLYMERS (2022)

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Review Pharmacology & Pharmacy

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Anyamanee Chaiprasongsuk et al.

Summary: Ethnopharmacological studies are valuable in the development of botanical products for preventing and treating various skin problems caused by UV radiation. Understanding the role of phytochemicals in skin damage and aging can help develop effective photoprotective agents. Phytochemicals can regulate cell homeostasis and improve skin integrity and function, delaying the aging process.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cell Biology

Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment

Linghui Chen et al.

Summary: Research has shown that TRPV2 expression levels are significantly increased in the lens epithelial cells of diabetic cataract patients, and that a TRPV2 channel agonist can significantly increase [Ca2+] (i) under high-glucose conditions, leading to apoptosis. Inhibiting TRPV2 with specific siRNA can prevent apoptosis under high-glucose conditions, suggesting a key role for TRPV2 in high-glucose-induced apoptosis of lens epithelial cells.

CELLS (2022)

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Article Food Science & Technology

Effects of different antioxidants and their combinations on the oxidative stability of DHA algae oil and walnut oil

Xue-Chen Pei et al.

Summary: By monitoring Rancimat induction time (RIT), peroxide value (POV), and thiobarbituric acid-reactive substances (TBARS) of docosahexaenoic add (DHA) algae oil and walnut oil during accelerated storage, the study evaluated the effects of single and combined use of seven antioxidants on lipid oxidation. The results showed that samples with TPP had the strongest stability. The shelf lives of the oils were predicted using a linear regression model, and the optimal antioxidants were found to significantly prolong the shelf lives of DHA algae oil and walnut oil.

FOOD SCIENCE & NUTRITION (2022)

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Article Biochemistry & Molecular Biology

Relationship between Vitamin C Deficiency and Cognitive Impairment in Older Hospitalised Patients: A Cross-Sectional Study

Yogesh Sharma et al.

Summary: This study found an association between vitamin C deficiency and cognitive impairment in older hospitalised patients. The analysis showed that lower levels of vitamin C were significantly related to lower cognitive function, suggesting that vitamin C deficiency may increase the risk of cognitive impairment.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Uncovering the Industrial Potentials of Lemongrass Essential Oil as a Food Preservative: A Review

Fatima Faheem et al.

Summary: This article explores the role of lemongrass and its essential oil in food preservation. Lemongrass has significant antimicrobial and antioxidant activity, making it a natural preservative that can replace synthetic preservatives.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Antioxidants and Bioactive Compounds in Food: Critical Review of Issues and Prospects

Mia Kurek et al.

Summary: This review paper provides insights into effective delivery mechanisms for health-promoting substances and discusses the challenges of using antioxidants and bioactives in foods. It covers the selection criteria, extraction methods, incorporation techniques, and delivery mechanisms for bioactives in a bioavailable form. The paper also gives an overview of existing methods for determining bioactivity. It emphasizes the importance of scientifically evaluating the effects of foods or food components on consumer health before making health claims, and acknowledges the ongoing challenges despite existing research progress.

ANTIOXIDANTS (2022)

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Article Biochemistry & Molecular Biology

Impact of Bioactive Compounds of Plant Leaf Powders in White Chocolate Production: Changes in Antioxidant Properties during the Technological Processes

Szymon Polinski et al.

Summary: This study evaluated the antioxidant properties of white chocolate supplemented with matcha green tea powder and moringa leaf powder. The results showed that matcha green tea powder had higher antioxidant properties compared to moringa leaf powder. Moringa leaf powder increased the content of lipophilic antioxidants in the chocolate, which also have health benefits. The incorporation of these additives during the tempering process was more relevant to improving the antioxidant properties of the white chocolate.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Natural Polyphenols for Treatment of Colorectal Cancer

Yiwen Zhang et al.

Summary: Natural polyphenols are promising chemopreventive agents for colorectal cancer, as they can regulate molecular and signaling pathways, inhibit tumor formation and progression. Combination treatment with different natural polyphenols can enhance the therapeutic effects and reduce side effects.

MOLECULES (2022)

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Review Pharmacology & Pharmacy

Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of Oxidation

Jasmine Musakhanian et al.

Summary: The use of lipid-based formulations is crucial in addressing solubility and bioavailability issues of new drug entities. Despite the scarcity of literature on lipid excipient chemistry, excipients with sensitive moieties offer drug delivery solutions that may outweigh the manageable oxidative challenges they present. Understanding formulation stability and taking appropriate steps to meet challenges ahead is essential in successful formulation development.

AAPS PHARMSCITECH (2022)

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Review Biochemistry & Molecular Biology

Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications

Sonia Losada-Barreiro et al.

Summary: Natural antioxidants sourced from fruits, vegetables, meats, eggs, and fish are essential for protecting cells, reducing food loss, improving health, and promoting sustainability in food and pharmaceutical systems. Nanotechnology-based formulations show promise in enhancing the pharmacological action and bioavailability of antioxidants, addressing the challenge of poor bioavailability in clinical applications.

BIOMEDICINES (2022)

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Article Biochemistry & Molecular Biology

Is There an Optimal Combination of AREDS2 Antioxidants Zeaxanthin, Vitamin E and Vitamin C on Light-Induced Toxicity of Vitamin A Aldehyde to the Retina?

Malgorzata B. Rozanowska et al.

Summary: The study aimed to determine the optimal combinations of vitamins C, E, and zeaxanthin to prevent phototoxicity mediated by vitamin A aldehyde. Results showed that combining zeaxanthin with alpha-tocopherol provided substantial protection, enhancing cell viability significantly.

ANTIOXIDANTS (2022)

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Review Food Science & Technology

Benefits and Risks Associated with Meat Consumption during Key Life Processes and in Relation to the Risk of Chronic Diseases

Carlotta Giromini et al.

Summary: Red meat, as an important part of the diet, provides essential nutrients and high-quality protein. This paper discusses the dietary role and impact of red meat in various chronic conditions, and the different effects of red and white meat on the risk of these diseases. The paper also highlights the role of red meat in maintaining muscle and bone health, as well as during pregnancy.

FOODS (2022)

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Review Food Science & Technology

Brown Algae as Functional Food Source of Fucoxanthin: A Review

Nur Akmal Solehah Din et al.

Summary: This article reviews the availability and biosynthesis of fucoxanthin in brown seaweed, as well as its mechanisms. The research findings suggest that fucoxanthin possesses various beneficial bioactivities such as antioxidant, anti-inflammatory, and anti-obesity effects. Moreover, the potential of fucoxanthin as a functional food ingredient is discussed to promote its wider application.

FOODS (2022)

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Review Plant Sciences

Metabolism and Regulation of Ascorbic Acid in Fruits

Xianzhe Zheng et al.

Summary: This paper systematically reviews the regulatory mechanism of ascorbic acid metabolism in fruits in recent decades, providing a theoretical basis for further research on the important role of ascorbic acid in fruits and the cultivation of fruits rich in ascorbic acid.

PLANTS-BASEL (2022)

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Article Food Science & Technology

Evaluation of Antioxidant Capacity (ABTS and CUPRAC) and Total Phenolic Content (Folin-Ciocalteu) Assays of Selected Fruit, Vegetables, and Spices

Jenson George et al.

Summary: Antioxidant capacity assays are important but face challenges in terms of correlation, reproducibility, and comparability of results. This study measured the AOX capacities and total phenolic content of various fruits, vegetables, and spices using different assay systems and solvents. The results showed that using different systems and solvents improved the reliability and understandability of the results, providing a basis for a reference database for AOX capacities.

INTERNATIONAL JOURNAL OF FOOD SCIENCE (2022)

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Article Chemistry, Applied

Comparing the antioxidant activity of gallic acid and its alkyl esters in emulsion gel and non-gelled emulsion

Malihe Keramat et al.

FOOD CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis

Zijun Wu et al.

Summary: Hydropersulfides (RSSH) play important roles in vivo as scavengers of oxidants and electrophiles. They are highly reactive towards phospholipid-derived peroxyl radicals and can effectively inhibit ferroptosis. The reactivity of RSSH can be improved by designing specific precursors. RSSH and their precursors have been shown to inhibit ferroptosis in cell culture.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Biochemistry & Molecular Biology

Brassica Genus Seeds: A Review on Phytochemical Screening and Pharmacological Properties

Jawaher Ayadi et al.

Summary: This review summarizes recent research on the phytochemistry, bioactivity, dietary importance, and toxicity of Brassica seeds. It has been found that Brassica seeds are rich in polyphenols, glucosinolates, and other active compounds, which exhibit antioxidant, anticancer, antimicrobial, anti-inflammatory, antidiabetic, and neuroprotective activities. These functional properties of Brassica seeds are important for the prevention and treatment of chronic diseases such as obesity, diabetes, cancer, and COVID-19.

MOLECULES (2022)

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Review Biochemistry & Molecular Biology

The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions

Geir Bjorklund et al.

Summary: This review provides an analysis of the sources of astaxanthin (ASX) and its health benefits as a potent antioxidant in the aging process. ASX is a liposoluble carotenoid naturally synthesized by microalgae, yeasts, and bacteria. It has been found to be a more significant antioxidant agent than other antioxidants, and has important nutraceutical applications and health benefits, especially in healthy aging processes. However, further research is needed to understand the mechanisms through which ASX exerts its effects.

MOLECULES (2022)

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Review Nutrition & Dietetics

Vitamin E in Cancer Treatment: A Review of Clinical Applications in Randomized Control Trials

Jennifer Donnelly et al.

Summary: This review explored recent randomized control trials of Vitamin E in cancer management and found heterogeneous results, making it difficult to reach a consensus on the effectiveness of Vitamin E. Further well-designed prospective trials are needed to establish the safety and efficacy of Vitamin E.

NUTRIENTS (2022)

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Article Nutrition & Dietetics

Does a Plant-Based Diet Stand Out for Its Favorable Composition for Heart Health? Dietary Intake Data from a Randomized Controlled Trial

Justina Dressler et al.

Summary: A plant-based diet (PBD) can provide numerous health benefits for patients with cardiovascular risk factors. The present study found that a PBD has a more favorable nutrient composition for cardiovascular health compared to an omnivorous dietary pattern. It can lead to a decrease in body weight, body mass index, waist circumference, HbA1c, and fasting blood glucose. However, deficiencies in vitamin B12, vitamin D, and iodine were observed in both groups.

NUTRIENTS (2022)

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Review Biochemistry & Molecular Biology

Addition of Natural Extracts with Antioxidant Function to Preserve the Quality of Meat Products

Elisa Rafaela Bonadio Bellucci et al.

Summary: This review summarizes the studies on the application of natural extracts from various plant sources as potential antioxidants in meat products, and discusses their roles in preserving product quality.

BIOMOLECULES (2022)

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Editorial Material Biochemistry & Molecular Biology

Advances in Natural Antioxidants for Food Improvement

Maria Lopez-Pedrouso et al.

ANTIOXIDANTS (2022)

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Article Biochemistry & Molecular Biology

Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go?

Barry Halliwell

Summary: The field of oxygen free radicals, antioxidants, and reactive oxygen species (ROS) has seen significant growth, with ROS playing important roles in living organisms. However, many studies lack mechanistic meaning. Detailed understanding of the molecular mechanisms of ROS and appropriate measurement methods for both ROS and oxidative damage are necessary for progress.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Environmental Sciences

Effects of malic acid and EDTA on oxidative stress and antioxidant enzymes of okra (Abelmoschus esculentus L.) exposed to cadmium stress

Afsaneh Mousavi et al.

Summary: Environmental stresses, including heavy metal pollution, are increasing and affecting arable lands. Chelators, such as malic acid and ethylenediaminetetraacetic acid, play a crucial role in the physiological and biochemical pathways of plants exposed to heavy metals. This study found that the application of malic acid and ethylenediaminetetraacetic acid can mitigate the toxic effects of Cd on okra plants by reducing oxidative stress and enhancing the antioxidant defense system.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Food Science & Technology

Plant-based animal product alternatives are healthier and more environmentally sustainable than animal products

Christopher J. Bryant

Summary: There are strong reasons to shift away from industrial animal agriculture and adopt plant-based animal product alternatives (PB-APAs) for reducing animal product consumption. PB-APAs are more environmentally sustainable and offer several health benefits.

FUTURE FOODS (2022)

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Article Health Care Sciences & Services

Antioxidant and Anti-Inflammatory Effects of Coenzyme Q10 Supplementation on Infectious Diseases

Sonia Sifuentes-Franco et al.

Summary: With the emergence of new viruses and infectious diseases, such as COVID-19, there is a need to search for adjuvant treatments that can improve the prognosis of infectious disease patients. Coenzyme Q10 has been studied for its anti-inflammatory and antioxidant effects, as well as its impact on mitochondrial dysfunction, making it a potential adjuvant treatment option.

HEALTHCARE (2022)

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Article Meteorology & Atmospheric Sciences

Impact of Dietary Meat and Animal Products on GHG Footprints: The UK and the US

Rebecca J. Barthelmie

Summary: The research examines the contribution of meat and animal products to global greenhouse gas emissions, finding that livestock emissions per capita are approximately 1 tCO2e/yr globally. Removing dietary meat is found to have a larger reduction in greenhouse gas emissions, similar to avoiding one long-haul flight or driving 100 miles less each week.

CLIMATE (2022)

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Review Oncology

The role of ROS in tumour development and progression

Eric C. Cheung et al.

Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.

NATURE REVIEWS CANCER (2022)

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Review Cell Biology

Ferroptosis: machinery and regulation

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. Lipoxygenase is the main promoter of ferroptosis, while GPX4 is the central repressor of this process.

AUTOPHAGY (2021)

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Review Chemistry, Medicinal

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

Ana C. Goncalves et al.

Summary: Anthocyanins, bioactive compounds found in red fruits and vegetables, have notable scavenging, anti-apoptotic, and anti-inflammatory activities, making them beneficial for health. They are recommended as supplementation to alleviate diseases, with studies pointing to various potential health benefits from their daily intake.

PHARMACEUTICALS (2021)

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Article Fisheries

The influence of dietary coenzyme Q10 and vitamin C on the growth rate, immunity, oxidative-related genes, and the resistance against Streptococcus agalactiae of Nile tilapia (Oreochromis niloticus)

Mohammed F. El Basuini et al.

Summary: The study showed that dietary supplementation of different doses of Coenzyme Q10 and Vitamin C to Nile tilapia significantly influenced growth performance, digestive enzyme activity, blood indices, immune response, and antioxidative capacity, particularly enhancing the resistance of fish against Streptococcus agalactiae infection.

AQUACULTURE (2021)

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Review Biochemistry & Molecular Biology

Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review

Biswajita Pradhan et al.

Summary: This review focuses on the diversity of functional compounds extracted from algae and their potential beneficial effects in fighting cancer, diabetes, and inflammatory diseases. Algal bioactive compounds are considered as a potential source of novel antioxidant and anticancer agents. Secondary metabolites in marine Algae, such as phenolic acids, flavonoids, and tannins, could have great therapeutic implications against several diseases.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Chengfei Xu et al.

Summary: Ferroptosis is a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation. It has unique biological processes and pathophysiological characteristics compared to other forms of cell death. Understanding the role of ferroptosis in disease progression, particularly in gastrointestinal diseases, has potential implications for novel therapeutic interventions in clinical settings.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Food Science & Technology

Evaluating the Anti-Inflammatory and Antioxidant Effects of Broccoli Treated with High Hydrostatic Pressure in Cell Models

Yi-Yuan Ke et al.

Summary: High-pressure processing can increase the isothiocyanate content in broccoli, while improving total phenolic content and enhancing nutritional value. This method also stimulates myrosinase activity, prevents loss of heat-sensitive components, and effectively inhibits oxidases to maintain food quality. Additionally, high pressures have anti-inflammatory and antioxidant effects, making it a potential treatment strategy for healthy foods.

FOODS (2021)

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Review Chemistry, Medicinal

Antioxidant Compounds from Microalgae: A Review

Noemie Coulombier et al.

Summary: The demand for natural products isolated from microalgae has increased in the past decade, especially natural antioxidants as an alternative to synthetic ones. Microalgae possess various advantages for biotechnological applications, including high biodiversity, photosynthetic yield, growth, productivity, and metabolic plasticity. This review aims to cover the diversity of antioxidant compounds, their mode of action, as well as various assays used to assess antioxidant activity in microalgae, in order to improve the selection of suitable assays for evaluating microalgae antioxidant activity.

MARINE DRUGS (2021)

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Review Cell Biology

The Role of Oxidative Stress and Antioxidant Balance in Pregnancy

Tarique Hussain et al.

Summary: Oxidative stress disrupts the balance between reactive oxygen species and antioxidants in the body, affecting various developmental processes during pregnancy. Excessive oxidative stress can lead to reproductive failure and pregnancy complications, highlighting the importance of maintaining oxidative and antioxidant balance at different stages of pregnancy.

MEDIATORS OF INFLAMMATION (2021)

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Article Biochemistry & Molecular Biology

Two New Isoprenoid Flavonoids from Sophora flavescens with Antioxidant and Cytotoxic Activities

Jingjing Li et al.

Summary: By investigating the isoprenoid flavonoids from Sophora flavescens, two new compounds were discovered to show significant antioxidant and anti-tumor activities, indicating their potential as active agents.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals

Su-Min Baek et al.

Summary: SMP30, a cell survival factor, plays an important role in vitamin C synthesis and antiapoptosis. Its expression in mammary carcinoma increases with the malignancy of glandular epithelial cells, suggesting a role in cancer cell survival. The consistent expression pattern of SMP30 in mammary carcinoma across different species makes it a potentially useful diagnostic marker for identifying cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Lipid peroxidation in brain tumors

Morana Jaganjac et al.

Summary: Evidence suggests lipid peroxidation is crucial in disease development, with 4-HNE acting as a key factor. 4-HNE affects blood-brain barrier functionality by forming stable protein adducts. Further research is needed on the role of 4-HNE in carcinogenesis and tumor defense.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Review Cell Biology

Lycopene: Food Sources, Biological Activities, and Human Health Benefits

Usman Mir Khan et al.

Summary: Lycopene, as an antioxidant found in tomatoes, plays a crucial role in preventing fat autoxidation and is beneficial for cardiovascular health. Dietary intake of lycopene has positive effects on preventing heart disease, improving lipid levels, and reducing inflammation.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Medicine, Research & Experimental

Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway

Meng-Yu Zhang et al.

Summary: The study found that cigarette smoke induces inflammation and promotes pyroptosis in 16HBE cells through the ROS/NLRP3/caspase-1 pathway.

LIFE SCIENCES (2021)

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Article Food Science & Technology

Gallic acid and its alkyl esters emerge as effective antioxidants against lipid oxidation during hot air drying process of Ostrea talienwhanensis

Man-Tong Zhao et al.

Summary: This study investigated the antioxidant efficiency of gallic acid and its alkyl esters in oyster tissue during hot-air drying process. Results showed that these compounds effectively inhibited lipid oxidation in oyster tissue, with the antioxidant effects increasing with alkyl chain length. However, the antioxidant effects gradually decreased after a certain point. Pearson correlation analysis revealed a positive correlation between antioxidant effects and concentrations of polyphenol compounds in oyster tissue.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

Abdelhafid Nani et al.

Summary: Nutrition transition refers to a shift in food habits characterized by high-fat, high-calorie, and high-salt food consumption, while neglecting dietary fibers, minerals, and vitamins. The Mediterranean-style diet, rich in antioxidants like polyphenols, is encouraged for its ability to combat obesity-related oxidative stress and inflammation.

MOLECULES (2021)

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Article Oncology

Prospective study of plasma levels of coenzyme Q10 and lung cancer risk in a low-income population in the Southeastern United States

Chris Shidal et al.

Summary: This study found that low plasma CoQ10 levels were significantly associated with an increased risk of lung cancer, particularly among current smokers. The stronger association shortly following the blood draw suggests that CoQ10 may be related to disease progression.

CANCER MEDICINE (2021)

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Review Pharmacology & Pharmacy

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

Umme Tamanna Ferdous et al.

Summary: Antioxidant supplementation can reduce side effects in cancer treatment, protect normal cells, inhibit tumor growth, improve chemotherapy response, and enhance quality of life in cancer patients. Algae, including micro and macro varieties, provide diverse antioxidants that can be utilized in the pharmaceutical industry, despite being in the early stages of investigation and utilization.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Antioxidants, Food Processing and Health

Borut Poljsak et al.

Summary: The article discusses the impact of oxidized forms of natural antioxidants on health during food processing, highlighting their role in cell signaling, gene expression, and potential health benefits through activation of damage repair processes and antioxidative defense systems. Additionally, it points out the importance of functional studies to understand the effects of antioxidants on organisms and the potential synergistic effects of reduced or oxidized antioxidants and their metabolites.

ANTIOXIDANTS (2021)

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Article Chemistry, Medicinal

New isolate from Salvinia molesta with antioxidant and urease inhibitory activity

Nadra Naheed et al.

Summary: The study focused on identifying new bioactive compounds with urease inhibitory activity from Salvinia molesta. A novel glucopyranose derivative and four known glycosides were isolated, with the novel compound showing promising antioxidant potential and urease inhibition. Molecular dynamic simulations supported the binding mode of the compound with urease, suggesting its potential as a lead for further studies as an antioxidant and urease inhibitor.

DRUG DEVELOPMENT RESEARCH (2021)

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Article Biochemical Research Methods

Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography

Gabriela C. Schroeder et al.

Summary: Metalloproteins catalyze reactions with enhanced chemical functionality due to their metal cofactor. However, radiation damage in structural studies can introduce artefacts complicating interpretation. Neutron protein crystallography remains the only probe leaving samples devoid of radiation damage.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2021)

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Article Environmental Sciences

Exposure to butylated hydroxytoluene compromises endometrial decidualization during early pregnancy

Zhifang Sun et al.

Summary: This study found that gestational exposure to BHT inhibits decidualization of mouse endometrium during early pregnancy, resulting in a decrease in the number of implantation sites and uterine weight. Additionally, BHT suppressed the decidual morphology of endometrial stromal cells and significantly decreased the expression of decidual markers. Furthermore, BHT exposure led to upregulation of reproductive hormones and hormone receptor signals in early pregnancy.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Toxicology

Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats

T. Kiremitli et al.

Summary: This study investigated the preventive effects of CoQ10 on methotrexate-induced utero-ovarian damage and oxidative stress in rats. Results showed that CoQ10 has significant antioxidant effects, reversing the oxidative stress caused by MTX. CoQ10 may be useful for protecting ovarian and uterine tissue from injury caused by oxidative stress.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

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Review Endocrinology & Metabolism

Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling

Priyanka Ramesh et al.

Summary: Flavonoids are polyphenolic compounds found in various natural products with multiple applications, including anti-inflammatory, anti-oxidative, and anti-carcinogenic properties, as well as the ability to stimulate bone formation. They influence bone remodelling through various signaling pathways and play a crucial role in maintaining bone integrity and structure. Their effects on regulating angiogenesis, decreasing inflammatory cytokine levels, and scavenging reactive oxygen species further underscore their potential as a promising agent in treating bone-related ailments in the future.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

Celia Andres Juan et al.

Summary: Living species are constantly exposed to oxidants, leading to oxidative stress and disease. The induction of oxidative stress is caused by an imbalance between radical species and antioxidant defense systems, which can damage cellular biomolecules.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Aging Induces Hepatic Oxidative Stress and Nuclear Proteomic Remodeling in Liver from Wistar Rats

Brenda Barcena et al.

Summary: Aging is a universal and irreversible process that results in loss of adaptability. Prolonged fasting has a significant impact on lipid peroxidation in the liver of old rats, associated with downregulation of antioxidant genes and alterations in RNA splicing at the nuclear proteome level.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Astaxanthin for the Food Industry

Barbara Stachowiak et al.

Summary: Xanthophyll astaxanthin is an expensive and important industrial pigment commonly used in aquaculture, responsible for the pink and red color of salmonid meat and shrimp. It has strong antioxidative properties and health benefits, thus being utilized in nutraceuticals and cosmetics. However, its application in food technology is limited due to concerns about the effects of synthetic astaxanthin on human health and the high cost of natural astaxanthin.

MOLECULES (2021)

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Review Medicine, Legal

Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply?

Susan P. Felter et al.

Summary: This paper discusses the impact of IARC classification on consumers and products using the synthetic antioxidant BHA as an example. Despite the finding that the mechanism by which BHA induces tumors is not relevant to humans, the classification still resulted in product bans and labeling requirements.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2021)

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Review Chemistry, Physical

Recent Developments in Effective Antioxidants: The Structure and Antioxidant Properties

Monika Parcheta et al.

Summary: This study focuses on the role of antioxidants in healthy foods, particularly examining the properties of effective antioxidants and the impact of complexed ligands with selected metals on antioxidant effects. Experimental findings suggest that ligand antioxidants complexed with high ion potential metals exhibit enhanced antioxidant properties.

MATERIALS (2021)

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Review Immunology

Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials

Mina Alimohammadi et al.

Summary: CoQ10 supplementation significantly decreased levels of inflammatory biomarkers and MMPs in patients with breast cancer, suggesting a potential benefit in breast cancer treatment. Further controlled trials in other types of cancer are needed to confirm the effects of CoQ10 on tumor therapy.

INFLAMMOPHARMACOLOGY (2021)

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Editorial Material Biochemistry & Molecular Biology

Enzymatic and Non-Enzymatic Molecules with Antioxidant Function

Paola Irato et al.

ANTIOXIDANTS (2021)

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Review Behavioral Sciences

Interventions to reduce meat consumption by appealing to animal welfare: Meta-analysis and evidence-based recommendations

Maya B. Mathur et al.

Summary: Interventions aimed at reducing meat consumption by mentioning or portraying farm animals have been shown to be effective in the short term, significantly reducing meat consumption, purchases, or related intentions. These interventions emphasizing animal welfare concerns may operate on distinct, potent pathways according to psychological theory.

APPETITE (2021)

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Review Cell Biology

Mitochondria: Their relevance during oocyte ageing

Jiska van der Reest et al.

Summary: The oocyte is characterized by a high number of mitochondria with unique architecture, essential for energy production and cellular functions. Mitochondrial dysfunction, caused by aging or stress, can impact oocyte maturation and contribute to reproductive aging and age-related diseases. Targeting mitochondria could potentially promote oocyte rejuvenation and reproductive health.

AGEING RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Role of the TRPM4 channel in mitochondrial function, calcium release, and ROS generation in oxidative stress

Chen Wang et al.

Summary: Blocking the TRPM4 channel may protect the myocardium from oxidative stress by maintaining mitochondrial membrane potential and intracellular ATP levels, possibly through preventing aberrant increases in intracellular Ca2+ and ROS.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Reproductive Biology

Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice

Paulina Nguyen-Powanda et al.

Summary: The efficiency of antioxidant defense system decreases with aging, resulting in high levels of reactive oxygen species and DNA damage in spermatozoa. This study found that aging and removal of SOD1 (superoxide dismutase-1) lead to increased lipid peroxidation and DNA damage in germ cells.

BIOLOGY OF REPRODUCTION (2021)

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Review Oncology

Selenium stimulates the antitumour immunity: Insights to future research

Ali Razaghi et al.

Summary: Selenium is a crucial trace element for regulating immune functions and plays important roles in cancer. At nutritional low doses, selenium acts as an antioxidant, while at supra-nutritional high doses, selenium induces redox signaling and cell death.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Chemistry, Applied

Synthetic phenolic antioxidants: Metabolism, hazards and mechanism of action

Xiaoqing Xu et al.

Summary: This paper reviews the correlation between synthetic phenolic antioxidants and food peroxides, discusses the metabolism and harms of BHA, BHT, and TBHQ, stressing the importance of proper use. Improper use of these antioxidants can lead to carcinogenicity and other harmful effects, highlighting the potential risks associated with them.

FOOD CHEMISTRY (2021)

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Article Biotechnology & Applied Microbiology

Antioxidant activity and related chemical composition of extracts from Brazilian beach-cast marine algae: opportunities of turning a waste into a resource

Talissa Barroco Harb et al.

Summary: The study evaluated the antioxidant activity and chemical composition of methanolic and aqueous extracts from fifteen beach-cast marine algae from the Brazilian Coast. It found that brown macroalgae exhibited the highest antioxidant activities, followed by red algae, while green beach-cast algae had the lowest activities. The concentrations of phenolic compounds and carbohydrates showed a positive correlation with the antioxidant activities of the tested extracts.

JOURNAL OF APPLIED PHYCOLOGY (2021)

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Review Cell Biology

Antioxidant and Signal-Modulating Effects of Brown Seaweed-Derived Compounds against Oxidative Stress-Associated Pathology

Rahima Begum et al.

Summary: Seaweeds, especially brown seaweeds and their derived bioactive substances, have shown excellent antioxidant properties among various marine sources. Antioxidants play a vital role in the treatment of oxidative stress-related diseases. Research on seaweeds as complementary medicine offers potential therapeutic benefits for health and disease management.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Plant Sciences

Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

Srimanta Patra et al.

Summary: Dietary polyphenols demonstrate chemopreventive activity by modulating key molecular targets and pathways to limit cancer initiation and progression. Combining polyphenols with existing anticancer drugs enhances anticancer activity and offers promising perspectives for clinical applications.

PHYTOMEDICINE (2021)

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Article Cell Biology

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom Delanghe et al.

Summary: The study reveals that BHA functions as a direct inhibitor of RIPK1 enzymatic activity, protecting cells from necroptosis and apoptosis. This finding suggests new functions of RIPK1 beyond its previously known roles.

CELL DEATH & DISEASE (2021)

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Review Chemistry, Physical

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

Jolanta Flieger et al.

Summary: Natural extracts can be used for the green synthesis of metallic nanoparticles with antioxidant properties. Assessing the antioxidant activity of extracts remains a challenge, with no universal test available. Various in vitro chemical tests can quantify antioxidant activity, with a focus on methods based on nanoparticles in this paper.

MATERIALS (2021)

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Review Nutrition & Dietetics

Food Sources of Selenium and Its Relationship with Chronic Diseases

Wenli Hu et al.

Summary: Selenium is an essential micronutrient for mammals, with deficiency posing a serious threat to health. Biofortification strategies have been developed to combat selenium deficiency. While selenium supplementation is beneficial for preventing and treating chronic diseases, the effects may vary depending on individual baseline selenium status.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

Metabolites with Antioxidant Activity from Marine Macroalgae

Leto-Aikaterini Tziveleka et al.

Summary: Marine macroalgae, growing under intense UV radiation, have developed protective mechanisms and serve as an important source of antioxidants. They can be cultivated in coastal areas to provide sufficient quantities of antioxidants for commercial utilization.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Tumor-Induced Cardiac Dysfunction: A Potential Role of ROS

Priyanka Karekar et al.

Summary: The study suggests that tumor induction may cause cardiac dysfunction even before treatment or onset of cachexia. By investigating the Hippo-Yorkie pathway, it is found that Yki overexpression compromises cardiac function, which can be rescued with antioxidant treatment.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Terpenoids and Polyphenols as Natural Antioxidant Agents in Food Preservation

Ignacio Gutierrez-del-Rio et al.

Summary: Synthetic antioxidant food additives like BHA, BHT and TBHQ are facing challenges due to negative consumer perception, prompting food manufacturers to seek safer natural alternatives. Terpenoids and polyphenols, widely distributed in fruits and vegetables, show broad antioxidant effects and have the potential to replace synthetic antioxidants in food preservation, particularly in preventing lipid oxidation in high fat-containing foods.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Coenzyme Q10 and Cardiovascular Diseases

Francisco M. Gutierrez-Mariscal et al.

Summary: CoQ(10) plays a key role in the electron transport chain and acts as an antioxidant, deficiency of which can lead to chronic and age-related diseases, particularly in cardiovascular diseases. Clinical trials have analyzed the effect of CoQ(10) supplementation as a therapeutic approach to improve deficiencies in patients with cardiovascular diseases.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Lutein as a Modulator of Oxidative Stress-Mediated Inflammatory Diseases

Yu Jin Ahn et al.

Summary: Lutein, obtained from foods like dark green leafy vegetables and egg yolk, has antioxidant properties and can inhibit inflammatory mediators and signaling pathways, thus preventing the development of inflammatory diseases. This review discusses the anti-inflammatory function of lutein in various organs against diseases such as neurodegenerative disorders, eye diseases, diabetes, osteoporosis, cardiovascular diseases, skin diseases, liver injury, obesity, and colon diseases.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Fast Antioxidant Reaction of Polyphenols and Their Metabolites

Janusz M. Gebicki et al.

Summary: The negative correlation between diets rich in fruits and vegetables and the occurrence of cardiovascular disease, stroke, cancer, and other deleterious conditions may be partly due to flavonoids and other polyphenols. Recent research suggests that the antioxidant role of polyphenols in food may be based on incomplete understanding, and that their actual mechanism may involve regulating cell signalling pathways. New findings show that food polyphenols and their metabolites act as effective antioxidants by significantly increasing the antioxidant protection of cells and tissues.

ANTIOXIDANTS (2021)

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Review Food Science & Technology

Bioactive Compounds of Nutraceutical Value from Fishery and Aquaculture Discards

Mirko Mutalipassi et al.

Summary: Seafood by-products, often discarded as wastes, can actually provide bioactive molecules with potential applications in functional foods and biotechnology. These by-products not only hold untapped protein sources but also supply valuable compounds that can be used in the production of high-value nutraceuticals, contributing to a more sustainable circular economy.

FOODS (2021)

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Article Food Science & Technology

Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical

Alicia Lopez-Maldonado et al.

Summary: The study evaluated the antioxidant and metabolic effects of a dietary supplement based on ALA and ALC, finding significant preventive effects against oxidative stress and recommending 2 capsules as a reasonable dosage.

CURRENT RESEARCH IN FOOD SCIENCE (2021)

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Review Nutrition & Dietetics

Ascorbate is a multifunctional micronutrient whose synthesis is lacking in primates

Junichi Fujii

Summary: Ascorbate (vitamin C) is essential for primates, providing antioxidative action and reducing power to certain enzymes. Ascorbate-incompetent animals may have evolved stronger detoxification systems to compensate for their inability to produce ascorbate.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2021)

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Article Biochemistry & Molecular Biology

Chocolate as a food matrix reduces the bioavailability of galloylated catechins from green tea in healthy women

Rie Mukai et al.

Summary: The study evaluated the food matrix effects of chocolate on the absorption of green tea catechins in five healthy women. It was found that the plasma profiles of ECg were significantly affected by the chocolate matrix, with ECg persisting in the plasma for a longer period compared to EGCg.

FOOD & FUNCTION (2021)

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Review Cell Biology

Role of coenzymes in cancer metabolism

Maheshwor Thapa et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Review Nutrition & Dietetics

Recent Research on the Health Benefits of Blueberries and Their Anthocyanins

Wilhelmina Kalt et al.

ADVANCES IN NUTRITION (2020)

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Review Biochemistry & Molecular Biology

Manipulation of Ascorbate Biosynthetic, Recycling, and Regulatory Pathways for Improved Abiotic Stress Tolerance in Plants

Ronan C. Broad et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Selenium Anticancer Properties and Impact on Cellular Redox Status

Lolita Kursvietiene et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Catalase as a Molecular Target for Male Infertility Diagnosis and Monitoring: An Overview

Nuria Rubio-Riquelme et al.

ANTIOXIDANTS (2020)

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Article Biochemistry & Molecular Biology

The Anti-Proliferative and Anti-Invasive Effect of Leaf Extracts of Blueberry Plants Treated with Methyl Jasmonate on Human Gastric Cancer In Vitro Is Related to Their Antioxidant Properties

Alejandra Ribera-Fonseca et al.

ANTIOXIDANTS (2020)

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Editorial Material Biochemistry & Molecular Biology

Marine Algal Antioxidants

Clementina Sansone et al.

ANTIOXIDANTS (2020)

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Editorial Material Medicine, General & Internal

Diet, nutrition, and cancer risk: what do we know and what is the way forward?

Timothy J. Key et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Food Science & Technology

An insight on superoxide dismutase (SOD) from plants for mammalian health enhancement

Sarah Stephenie et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Green & Sustainable Science & Technology

A Comprehensive Review of the Benefits of and the Barriers to the Switch to a Plant-Based Diet

Andras Feher et al.

SUSTAINABILITY (2020)

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Review Nutrition & Dietetics

Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer's disease risk

Bradley J. Baranowski et al.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2020)

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Review Physiology

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Mehdi Sharifi-Rad et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Fisheries

Effects of dietary copper on growth, antioxidant capacity and immune responses of juvenile blunt snout bream (Megalobrama amblycephala) as evidenced by pathological examination

Hualiang Liang et al.

AQUACULTURE REPORTS (2020)

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Review Biochemistry & Molecular Biology

Concept, mechanism, and applications of phenolic antioxidants in foods

Alam Zeb

JOURNAL OF FOOD BIOCHEMISTRY (2020)

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Article Food Science & Technology

Effect of seaweed coating on quality characteristics and shelf life of tomato (Lycopersicon esculentum mill)

Thahira A. Banu et al.

FOOD SCIENCE AND HUMAN WELLNESS (2020)

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Review Nutrition & Dietetics

Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials

David J. A. Jenkins et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

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Review Veterinary Sciences

Vitamin C in Health and Disease: A Companion Animal Focus

Daniel S. Gordon et al.

TOPICS IN COMPANION ANIMAL MEDICINE (2020)

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Review Nutrition & Dietetics

Lutein Supplementation for Eye Diseases

Long Hin Li et al.

NUTRIENTS (2020)

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Review Nutrition & Dietetics

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES

Carroll A. Reider et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells

Lavinia-Lorena Pruteanu et al.

PLOS ONE (2020)

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Article Environmental Sciences

Tissue distribution, excretion, and metabolism of 2,6-di-tert-butyl-hydroxytoluene in mice

Ruirui Zhang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

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Review Pharmacology & Pharmacy

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Bahare Salehi et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Food Science & Technology

Contribution of Tocols to Food Sensorial Properties, Stability, and Overall Quality

Amelia Delgado et al.

JOURNAL OF FOOD QUALITY (2020)

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Review Chemistry, Medicinal

Recent Advances in Marine-Based Nutraceuticals and Their Health Benefits

Vida Simat et al.

MARINE DRUGS (2020)

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Article Nutrition & Dietetics

Association of Antioxidant Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort Study of Middle-Aged Adults

May A. Beydoun et al.

NUTRIENTS (2020)

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Article Biochemistry & Molecular Biology

Assessing the Impact of Oil Types and Grades on Tocopherol and Tocotrienol Contents in Vegetable Oils with Chemometric Methods

Yunqi Wen et al.

MOLECULES (2020)

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Article Plant Sciences

Molecular evolution of GDP-L-galactose phosphorylase, a key regulatory gene in plant ascorbate biosynthesis

Junjie Tao et al.

AOB PLANTS (2020)

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Selenium Biofortification and Interaction With Other Elements in Plants: A Review

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FRONTIERS IN PLANT SCIENCE (2020)

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A review on anti-cancer effect of green tea catechins

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JOURNAL OF FUNCTIONAL FOODS (2020)

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Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?

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Article Nutrition & Dietetics

Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions

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A nanostructure voltammetric platform amplified with ionic liquid for determination of tert-butylhydroxyanisole in the presence kojic acid

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JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION (2019)

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Review Biochemistry & Molecular Biology

Selenium-Fascinating Microelement, Properties and Sources in Food

Marek Kieliszek

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The importance of antioxidants and place in today's scientific and technological studies

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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2019)

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Review Chemistry, Medicinal

Polyphenols: A concise overview on the chemistry, occurrence, and human health

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Synthesis with Immobilized Lipases and Downstream Processing of Ascorbyl Palmitate

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Glut-1 explains the evolutionary advantage of the loss of endogenous vitamin C-synthesis The electron transfer hypothesis

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EVOLUTION MEDICINE AND PUBLIC HEALTH (2019)

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Antioxidants of Natural Plant Origins: From Sources to Food Industry Applications

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Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

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Intake of Nutrient and Non-Nutrient Dietary Antioxidants. Contribution of Macromolecular Antioxidant Polyphenols in an Elderly Mediterranean Population

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A Review of Dietary (Phyto)Nutrients for Glutathione Support

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Antioxidants versus Food Antioxidant Additives and Food Preservatives

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Vitamin C in Plants: From Functions to Biofortification

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ANTIOXIDANTS (2019)

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Antioxidant, Anticancer Activity and Phytochemical Analysis of Green Algae, Chaetomorpha Collected from the Arabian Gulf

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SCIENTIFIC REPORTS (2019)

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Evaluation of the synergistic effects of antioxidant activity on mixtures of the essential oil from Apium graveolens L., Thymus vulgaris L. and Coriandrum sativum L. using simplex-lattice design

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A combination of monoacylglycerol crystalline network and hydrophilic antioxidants synergistically enhances the oxidative stability of gelled algae oil

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Oxidative damage and antioxidative system in algae

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TOXICOLOGY REPORTS (2019)

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Comparison of Butylated Hydroxytoluene, Ascorbic Acid, and Clove Extract as Antioxidants in Fresh Beef Patties at Refrigerated Storage

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FOOD SCIENCE OF ANIMAL RESOURCES (2019)

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Article Nutrition & Dietetics

Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial

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EUROPEAN JOURNAL OF NUTRITION (2018)

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Endogenous non-enzymatic antioxidants in the human body

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ADVANCES IN MEDICAL SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Ascorbic acid metabolism and functions: A comparison of plants and mammals

Nicholas Smirnoff

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Antioxidants: Differing Meanings in Food Science and Health Science

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The Role of Catechins in Cellular Responses to Oxidative Stress

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The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

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Cancer Radiosensitizers

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Oncotarget (2018)

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Lycopene and Vascular Health

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Concurrent extraction of oil from roasted coffee (Coffea arabica) and fucoxanthin from brown seaweed (Saccharina japonica) using supercritical carbon dioxide

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JOURNAL OF CO2 UTILIZATION (2018)

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The Increased Endogenous Sulfur Dioxide Acts as a Compensatory Mechanism for the Downregulated Endogenous Hydrogen Sulfide Pathway in the Endothelial Cell Inflammation

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FRONTIERS IN IMMUNOLOGY (2018)

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Using Thymus carmanicus and Myrtus communis essential oils to enhance the physicochemical properties of potato chips

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FOOD SCIENCE & NUTRITION (2018)

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Review Orthopedics

Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries A Systematic Review

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ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE (2018)

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Review Cardiac & Cardiovascular Systems

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Review Biochemistry & Molecular Biology

Oxidative DNA damage & repair: An introduction

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FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Review Cell Biology

Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Review Pharmacology & Pharmacy

Beneficial roles of honey polyphenols against some human degenerative diseases: A review

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PHARMACOLOGICAL REPORTS (2017)

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Review Public, Environmental & Occupational Health

Association between green tea intake and risk of gastric cancer: a systematic review and dose-response meta-analysis of observational studies

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PUBLIC HEALTH NUTRITION (2017)

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Review Nutrition & Dietetics

The Roles of Vitamin C in Skin Health

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Review Food Science & Technology

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

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Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA

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Carotenoids from Marine Organisms: Biological Functions and Industrial Applications

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Natural Forms of Vitamin E as Effective Agents for Cancer Prevention and Therapy

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ADVANCES IN NUTRITION (2017)

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Gallic Acid and Dodecyl Gallate Prevents Carbon Tetrachloride-Induced Acute and Chronic Hepatotoxicity by Enhancing Hepatic Antioxidant Status and Increasing p53 Expression

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Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA

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NUTRITION JOURNAL (2016)

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Coenzyme Q biosynthesis and its role in the respiratory chain structure

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Natural antioxidants as food and feed additives to promote health benefits and quality of meat products: A review

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Detecting the oxyl radical of photocatalytic water oxidation at an n-SrTiO3/aqueous interface through its subsurface vibration

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Interplay of genetic and epigenetic alterations in hepatocellular carcinoma

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Conservation and Expression Patterns Divergence of Ascorbic Acid D-mannose/L-galactose Pathway Genes in Brassica rapa

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The Cu, Zn Superoxide Dismutase: Not Only a Dismutase Enzyme

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Food preservatives - An overview on applications and side effects

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EMIRATES JOURNAL OF FOOD AND AGRICULTURE (2016)

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Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans

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CURRENT PHARMACEUTICAL DESIGN (2016)

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Review Biochemistry & Molecular Biology

Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Biochemistry & Molecular Biology

Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis

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ANTIOXIDANTS & REDOX SIGNALING (2015)

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Oxidative stress inhibits distant metastasis by human melanoma cells

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NATURE (2015)

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Article Food Science & Technology

Oxygen radical absorbance capacity (ORAC): New horizons in relating dietary antioxidants/bioactives and health benefits

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Biological activities of two macroalgae from Adriatic coast of Montenegro

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Review Biochemistry & Molecular Biology

Oxidative stress: a concept in redox biology and medicine

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2,6-Di-Tert-Butyl-Hydroxytoluene and Its Metabolites in Foods

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INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2015)

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Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

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INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2015)

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Free radicals, natural antioxidants, and their reaction mechanisms

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Medicinal importance of gallic acid and its ester derivatives: a patent review

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PHARMACEUTICAL PATENT ANALYST (2015)

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Review Biochemistry & Molecular Biology

Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction

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Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications

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Superoxide Dismutases and Superoxide Reductases

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Trends in the use of natural antioxidants in active food packaging: a review

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FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2014)

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EFFECTIVENESS OF CLOVE ESSENTIAL OIL AND GRAPE SEED EXTRACT COMBINATION ON MICROBIAL AND LIPID OXIDATION CHARACTERISTICS OF RAW BUFFALO PATTY DURING STORAGE AT ABUSE REFRIGERATION TEMPERATURE

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Article Biochemistry & Molecular Biology

The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism

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Review Biochemistry & Molecular Biology

Potential Role of Sulfur-Containing Antioxidant Systems in Highly Oxidative Environments

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MOLECULES (2014)

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Review Chemistry, Medicinal

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications-A Review

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Review Physiology

SELENOPROTEINS: MOLECULAR PATHWAYS AND PHYSIOLOGICAL ROLES

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Article Cell Biology

Antioxidants Accelerate Lung Cancer Progression in Mice

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SCIENCE TRANSLATIONAL MEDICINE (2014)

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Review Biochemistry & Molecular Biology

Redox Regulation of T-Cell Function: From Molecular Mechanisms to Significance in Human Health and Disease

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ANTIOXIDANTS & REDOX SIGNALING (2013)

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Article Biochemistry & Molecular Biology

Conserved or Lost: Molecular Evolution of the Key Gene GULO in Vertebrate Vitamin C Biosynthesis

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Natural antioxidants in meat and poultry products

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Chemical and physical methodologies for the replacement/reduction of sulfur dioxide use during winemaking: review of their potentialities and limitations

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EUROPEAN FOOD RESEARCH AND TECHNOLOGY (2012)

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Critical review: vegetables and fruit in the prevention of chronic diseases

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Article Food Science & Technology

Moringa oleiferia leaves extract: a natural antioxidant for retarding lipid peroxidation in cooked goat meat patties

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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2012)

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Article Oncology

δ-Tocopherol Is More Active than α- or γ-Tocopherol in Inhibiting Lung Tumorigenesis In Vivo

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CANCER PREVENTION RESEARCH (2011)

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Review Food Science & Technology

Ascorbic Acid: A Review of its Chemistry and Reactivity in Relation to a Wine Environment

Marc P. Bradshaw et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2011)

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The Genetics of Vitamin C Loss in Vertebrates

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CURRENT GENOMICS (2011)

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A Randomized, Double-Blinded, Placebo-Controlled Study of the Effect of a Combination of Lemon Verbena Extract and Fish Oil Omega-3 Fatty Acid on Joint Management

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JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2011)

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Review Food Science & Technology

Green tea and prevention of esophageal and lung cancers

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MOLECULAR NUTRITION & FOOD RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Carotenoids and Their Isomers: Color Pigments in Fruits and Vegetables

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Review Chemistry, Medicinal

Bromophenols in Marine Algae and Their Bioactivities

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Review Chemistry, Medicinal

Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases

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MARINE DRUGS (2011)

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Review Chemistry, Medicinal

Microalgae as Sources of Carotenoids

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Glutathione: mechanism and kinetics of its non-enzymatic defense action against free radicals

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RSC ADVANCES (2011)

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Letter Pharmacology & Pharmacy

Coenzyme Q10: The essential nutrient

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JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2011)

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Article Biochemistry & Molecular Biology

A supramolecular bifunctional artificial enzyme with superoxide dismutase and glutathione peroxidase activities

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BIOORGANIC CHEMISTRY (2010)

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Article Biochemistry & Molecular Biology

Ascorbate Synthesis Pathway DUAL ROLE OF ASCORBATE IN BONE HOMEOSTASIS

Kenneth H. Gabbay et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Review Cell Biology

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)

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Article Endocrinology & Metabolism

Effect of different dietary zinc levels on hepatic antioxidant and micronutrients indices under oxidative stress conditions

Rashmi S. Tupe et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2010)

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Article Nutrition & Dietetics

The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide

Monica H. Carlsen et al.

NUTRITION JOURNAL (2010)

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Review Nutrition & Dietetics

Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review

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AMERICAN JOURNAL OF CLINICAL NUTRITION (2009)

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Review Biochemistry & Molecular Biology

Glutathione dysregulation and the etiology and progression of human diseases

Nazzareno Ballatori et al.

BIOLOGICAL CHEMISTRY (2009)

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Article Chemistry, Applied

Classification of fruits and vegetables

Jean A. T. Pennington et al.

JOURNAL OF FOOD COMPOSITION AND ANALYSIS (2009)

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Article Cell Biology

Comparative effects of β-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats

R. K. Sangeetha et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2009)

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Review Biochemistry & Molecular Biology

Glutathione: Overview of its protective roles, measurement, and biosynthesis

Henry Jay Forman et al.

MOLECULAR ASPECTS OF MEDICINE (2009)

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Review Multidisciplinary Sciences

The DNA-damage response in human biology and disease

Stephen P. Jackson et al.

NATURE (2009)

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Article Oncology

Selenium, Folate, and Colon Cancer

Alexandra Connelly-Frost et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)

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Article Cardiac & Cardiovascular Systems

Astaxanthin: A novel potential treatment for oxidative stress and inflammation in cardiovascular disease

Fredric J. Pashkow et al.

AMERICAN JOURNAL OF CARDIOLOGY (2008)

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Article Nutrition & Dietetics

Influence of lycopene and vitamin C from tomato juice on biomarkers of oxidative stress and inflammation

Karin Jacob et al.

BRITISH JOURNAL OF NUTRITION (2008)

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Review Biochemistry & Molecular Biology

Allenic and cumulenic lipids

Valery M. Dembitsky et al.

PROGRESS IN LIPID RESEARCH (2007)

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Review Nutrition & Dietetics

New developments and novel therapeutic perspectives for vitamin C

Yi Li et al.

JOURNAL OF NUTRITION (2007)

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Article Biochemistry & Molecular Biology

Physiological levels of tea catechins increase cellular lipid antioxidant activity of vitamin C and vitamin E in human intestinal Caco-2 cells

Janjira Intra et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2007)

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Review Biochemistry & Molecular Biology

Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay

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MOLECULES (2007)

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Review Biochemistry & Molecular Biology

Vitamin C - Biosynthesis, recycling and degradation in mammals

Carole L. Linster et al.

FEBS JOURNAL (2007)

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Review Food Science & Technology

Astaxanthin: A review of its chemistry and applications

I Higuera-Ciapara et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2006)

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Review Rheumatology

Musculoskeletal manifestations of scurvy

O Fain

JOINT BONE SPINE (2005)

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Review Biotechnology & Applied Microbiology

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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2004)

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Article Primary Health Care

The role of antioxidants in exercise and disease prevention

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PHYSICIAN AND SPORTSMEDICINE (2002)

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Article Biochemistry & Molecular Biology

Influence of stress on astaxanthin production in Haematococcus pluvialis grown under different culture conditions

R Sarada et al.

PROCESS BIOCHEMISTRY (2002)

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Article Nutrition & Dietetics

A systematic screening of total antioxidants in dietary plants

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JOURNAL OF NUTRITION (2002)

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