Targeting Neutrophil β2-Integrins: A Review of Relevant Resources, Tools, and Methods

Neutrophils are important innate immune cells that respond during inflammation and infection. These migratory cells utilize beta(2)-integrin cell surface receptors to move out of the vasculature into inflamed tissues and to perform various anti-inflammatory responses. Although critical for fighting off infection, neutrophil responses can also become dysregulated and contribute to disease pathophysiology. In order to limit neutrophil-mediated damage, investigators have focused on beta(2)-integrins as potential therapeutic targets, but so far these strategies have failed in clinical trials. As the field continues to move forward, a better understanding of beta(2)-integrin function and signaling will aid the design of future therapeutics. Here, we provide a detailed review of resources, tools, experimental methods, and in vivo models that have been and will continue to be utilized to investigate the vitally important cell surface receptors, neutrophil beta(2)-integrins.

Automated summary

Neutrophils use beta(2)-integrin cell surface receptors to move out of blood vessels and respond to inflammation and infection. However, dysregulated neutrophil responses can contribute to disease pathophysiology. Investigating the function and signaling of beta(2)-integrins can help in designing future therapeutics.