4.7 Article

Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions

Shima Kouhnavardi et al.

Summary: Dopamine and DAT signaling dysfunctions are associated with various neuropsychiatric disorders and progressive brain diseases, leading to devastating personal and familial concerns and high socioeconomic costs worldwide.

BIOMOLECULES (2022)

Article Neurosciences

The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology

Renee A. Rotolo et al.

Summary: Depressed individuals often experience effort-related motivational symptoms such as anergia and fatigue that are not effectively treated with commonly used antidepressants. New atypical DAT inhibitors like CT-005404 have shown promise in reversing the effects of dopamine depleting agents and pro-inflammatory cytokines, offering potential as a new avenue for treating motivational dysfunctions in humans.

NEUROPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats

Istvan Gyertyan et al.

Summary: The study tested a potential cognitive enhancer CE-123 in a rodent cognitive test system and found that it significantly enhanced motivation and improved performance in certain cognitive tasks, while not affecting attention, spatial, and motor learning. Proteomic analysis revealed changes in proteins associated with aging and neurodegeneration, indicating a potential link between the cognitive effects of the compound and altered synaptic systems.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

Pharmacology of Drugs Used as Stimulants

James R. Docherty et al.

Summary: The effects of psychostimulants involve various neurotransmitter pathways and can lead to serious adverse events, including potentially life-threatening hyperthermia. Recreational users should be aware of the dangers associated with these substances.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Behavioral Sciences

Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice

Judith Camats-Perna et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2019)

Article Geriatrics & Gerontology

Mental Flexibility Influences the Association Between Poor Balance and Falls in Older People - A Secondary Analysis

Frederico Pieruccini-Faria et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Geriatrics & Gerontology

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task

Jana Lubec et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

Review Biochemistry & Molecular Biology

Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review

K. E. Hopperton et al.

MOLECULAR PSYCHIATRY (2018)

Article Behavioral Sciences

A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval

Martina Kristofova et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

Article Multidisciplinary Sciences

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease

Annalisa Nobili et al.

NATURE COMMUNICATIONS (2017)

Article Behavioral Sciences

A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats

Agnieszka Nikiforuk et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2017)

Article Pharmacology & Pharmacy

Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum

E. Martinez-Pinilla et al.

BIOCHEMICAL PHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

Yiqing Yan et al.

Review Pharmacology & Pharmacy

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

N. Singewald et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Review Pharmacology & Pharmacy

Dopamine heteroreceptor complexes as therapeutic targets in Parkinson's disease

Kjell Fuxe et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

Review Clinical Neurology

Differential effects of dopamine-directed treatments on cognition

F. Gregory Ashby et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2015)

Article Behavioral Sciences

Dopamine Modulates Novelty Seeking Behavior During Decision Making

Vincent D. Costa et al.

BEHAVIORAL NEUROSCIENCE (2014)

Review Behavioral Sciences

Mechanisms of motivation-cognition interaction: challenges and opportunities

Todd S. Braver et al.

COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE (2014)

Review Neurosciences

Neuromodulation and aging: implications of aging neuronal gain control on cognition

Shu-Chen Li et al.

CURRENT OPINION IN NEUROBIOLOGY (2014)

Editorial Material Biochemistry & Molecular Biology

Understanding the Role of Heteroreceptor Complexes in the Central Nervous System

Kjell Fuxe et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2014)

Review Biology

The synaptic plasticity and memory hypothesis: encoding, storage and persistence

Tomonori Takeuchi et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Article Geriatrics & Gerontology

The immune marker CD68 correlates with cognitive impairment in normally aged rats

Mark Farso et al.

NEUROBIOLOGY OF AGING (2013)

Article Clinical Neurology

Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning

David Zilles et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2012)

Article Immunology

Neuroinflammation in Alzheimer's disease wanes with age

Jeroen J. M. Hoozemans et al.

JOURNAL OF NEUROINFLAMMATION (2011)

Article Geriatrics & Gerontology

Changes with aging in the dopaminergic and noradrenergic innervation of rat neocortex

Simon Allard et al.

NEUROBIOLOGY OF AGING (2011)

Review Behavioral Sciences

The role of the basal ganglia in learning and memory: Insight from Parkinson's disease

Karin Foerde et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2011)

Article Neurosciences

Effect of modafinil on learning performance and neocortical long-term potentiation in rats

Hector Burgos et al.

BRAIN RESEARCH BULLETIN (2010)

Review Neurosciences

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

Ethan S. Bromberg-Martin et al.

NEURON (2010)

Review Behavioral Sciences

Dopamine and adaptive memory

Daphna Shohamy et al.

TRENDS IN COGNITIVE SCIENCES (2010)

Article Multidisciplinary Sciences

Age-related changes in midbrain dopaminergic regulation of the human reward system

Jean-Claude Dreher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Neurosciences

Modafinil: A review of neurochemical actions and effects on cognition

Michael J. Minzenberg et al.

NEUROPSYCHOPHARMACOLOGY (2008)

Article Neurosciences

Prefrontal-hippocampal coupling during memory processing is modulated by COMT Val158met genotype

Alessandro Bertolino et al.

BIOLOGICAL PSYCHIATRY (2006)

Article Behavioral Sciences

Cocaine conditioning and sensitization: The habituation factor

Robert J. Carey et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)

Review Medicine, General & Internal

Ageing and the brain

R Peters

POSTGRADUATE MEDICAL JOURNAL (2006)

Article Neurosciences

Cytokines, chemokines, and cytokine receptors in human microglia

YB Lee et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2002)