The Effects of a High-Fat Diet on Inflammatory Bowel Disease

The interactions among diet, intestinal immunity, and microbiota are complex and play contradictory roles in inflammatory bowel disease (IBD). An increasing number of studies has shed light on this field. The intestinal immune balance is disrupted by a high-fat diet (HFD) in several ways, such as impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota. In contrast, a rational diet is thought to maintain intestinal immunity by regulating gut microbiota. In this review, we emphasize the crucial contributions made by an HFD to the gut immune system and microbiota.

Automated summary

The interactions among diet, intestinal immunity, and microbiota in inflammatory bowel disease (IBD) are complex and contradictory. Increasing research has provided insights into this field. A high-fat diet (HFD) disrupts intestinal immune balance by impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota. Conversely, a rational diet is believed to maintain intestinal immunity by regulating gut microbiota. This review emphasizes the crucial contributions of an HFD to the gut immune system and microbiota.