☆ 4.7 Article

Senopathies-Diseases Associated with Cellular Senescence

BIOMOLECULES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

Lei Zhang et al.

Summary: The concept of geroscience focuses on targeting the ageing process itself as a means to improve human health. Cellular senescence, a state of irreversible cell arrest, has emerged as a potential therapeutic target to extend healthspan. Senescent cells develop a secretory phenotype that promotes chronic inflammation and tissue dysfunction. Therapeutic drugs that induce selective cell death of senescent cells or suppress the expression of senescence markers are being developed.

FEBS JOURNAL (2023)

添加到收藏夹

Article Oncology

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Ines Marin et al.

Summary: Senescent cells possess various features that make them highly efficient in stimulating dendritic cells and antigen-specific CD8 T cells, including the release of alarmins, activation of IFN signaling, enhanced MHC class I machinery, and presentation of specific self-peptides. Immunization with senescent cancer cells induces strong antitumor protection mediated by DCs and CD8 T cells, surpassing the effectiveness of immunization with cancer cells undergoing immunogenic cell death. Furthermore, induction of senescence in human primary cancer cells enhances their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. This study highlights the potential of exploiting senescent cancer cells to develop efficient and protective CD8-dependent antitumor immune responses.

CANCER DISCOVERY (2023)

添加到收藏夹

Article Immunology

COVID-19 and cellular senescence

Clemens A. Schmitt et al.

Summary: The severity of COVID-19 is determined by host factors, with cellular senescence playing a critical role in the hyperinflammatory response caused by SARS-CoV-2. Elderly individuals have a higher proportion of senescent cells, leading to the spreading of cellular senescence and worsening symptoms such as cytokine storms. Targeted elimination of senescent cells may offer a novel therapeutic approach to attenuate clinical deterioration in COVID-19.

NATURE REVIEWS IMMUNOLOGY (2023)

添加到收藏夹

Article Cell Biology

Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

Isadora Matias et al.

Summary: The reduction of lamin-B1 is a hallmark of senescent astrocytes contributing to nuclear deformations, which are found in aged mouse brains and post-mortem human brain tissue. This study suggests a regional-dependent aging response of human astrocytes in the hippocampus, with implications for impaired astrocyte functions during aging.

AGING CELL (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The role of cellular senescence in cardiac disease: basic biology and clinical relevance

Mozhdeh Mehdizadeh et al.

Summary: This review discusses the role of cellular senescence in cardiac disease, outlines therapeutic strategies for targeting senescence, and considers potential implications for improving the management of patients with heart disease. The complex senescence-associated secretory phenotype (SASP) of senescent cells has important effects on cell and tissue biology. Future research is needed to better understand the precise role of senescent cells in various cardiac pathologies and develop strategies for preventing their accumulation.

NATURE REVIEWS CARDIOLOGY (2022)

添加到收藏夹

Review Cell Biology

The role of senescence in cellular plasticity Lessons from regeneration and development and implications for age-related diseases

Nadja Anneliese Ruth Ring et al.

Summary: This article discusses the paradoxical role of cellular senescence in cellular plasticity and provides insight into age-related diseases by integrating recent data on the interplay between cellular senescence and plasticity. It emphasizes recognizing senescence as a core mechanism of regeneration and development to better decipher age-related diseases.

DEVELOPMENTAL CELL (2022)

添加到收藏夹

Editorial Material Cell Biology

The role and biology of senescent cells in ageing-related tissue damage and repair

Markus Schosserer

MECHANISMS OF AGEING AND DEVELOPMENT (2022)

添加到收藏夹

Article Multidisciplinary Sciences

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Dominik Saul et al.

Summary: The authors present and validate a senescence gene set called SenMayo, which can accurately identify senescent cells across different tissues and species. Using this gene set, senescent cells can be characterized at the single cell level and key intercellular signaling pathways can be identified.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Review Oncology

Exploiting senescence for the treatment of cancer

Liqin Wang et al.

Summary: This review discusses how senescence can be induced in cancer cells and how the distinctive features of senescent cancer cells can be exploited for selective eradication. It also explores activation of the host immune system as an attractive way to clear senescent cancer cells, and the potential benefits of a sequential treatment approach with pro-senescence therapy followed by senolytic therapy.

NATURE REVIEWS CANCER (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Paul D. Robbins et al.

Summary: Senescence is a signaling mechanism activated in stressed cells to prevent proliferation of damaged cells, leading to chronic sterile inflammation and age-related diseases. Senescent cells accumulate with age and in diseased anatomical sites, making them a logical therapeutic target. Senotherapeutics, a new class of drugs, selectively kill senescent cells or suppress their disease-causing phenotypes, showing promising results in preclinical studies and clinical trials.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

添加到收藏夹

Article Cell Biology

Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Lei Zhang et al.

Summary: Inhibiting NF-κ B activation with SR12343 shows promising results in reducing cellular senescence markers, improving muscle fiber size, and extending healthy lifespan. The therapeutic effects of SR12343 were observed in different mouse models, suggesting it as a potential treatment for reducing cellular senescence and aging-related diseases.

AGING CELL (2021)

添加到收藏夹

Review Chemistry, Medicinal

Repurposing drugs to fight aging: The difficult path from bench to bedside

Alexander Vaiserman et al.

Summary: Life expectancy has been steadily increasing in developed countries, but healthspan extension has not kept pace. Aging is the main risk factor for age-associated pathological conditions. Repurposing existing medications to target the aging process for human healthspan extension faces challenges.

MEDICINAL RESEARCH REVIEWS (2021)

添加到收藏夹

Article Cell Biology

Breathe it in-Spotlight on senescence and regeneration in the lung

Julia Majewska et al.

Summary: Cellular senescence plays a crucial role in lung physiology and pathology, with transient senescent cells being essential in limiting lung damage and contributing to organ regeneration, while persistent accumulation of senescent cells drives age-related decline in organ function.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

添加到收藏夹

Article Cell Biology

The role of senolytics in osteoporosis and other skeletal pathologies

Madison L. Doolittle et al.

Summary: The skeletal system undergoes irreversible structural deterioration with aging, leading to increased fracture risk and detrimental changes in mobility, posture, and gait. Clearance of senescent cells may improve bone mass and microarchitecture, preventing age-related bone loss.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients

Jerome Mertens et al.

Summary: Our study identifies AD-related neuronal changes as age-dependent cellular programs that impair neuronal identity.

CELL STEM CELL (2021)

添加到收藏夹

Article Cell Biology

Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls

W. Andrew Owens et al.

Summary: Ageing is linked to increased risk of cardiovascular diseases, with cell senescence believed to play a role in the development of these diseases. Senolytics targeting aging cells show promise as a potential treatment for cardiovascular diseases, but may also pose complications that need to be considered in the context of the cardiovascular system.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Senescence-associated extracellular vesicle release plays a role in senescence-associated secretory phenotype (SASP) in age-associated diseases

Yoko Tanaka et al.

Summary: Cellular senescence serves as an important tumor suppression mechanism by inhibiting the proliferation of damaged cells. Irreparable DNA damage in senescent cells leads to the accumulation of genomic DNA fragments in the cytoplasm, triggering the secretion of inflammatory proteins and increasing the release of small extracellular vesicles. This phenomenon, known as senescence-associated secretory phenotype, plays a role in various physiological and pathological processes in the body.

JOURNAL OF BIOCHEMISTRY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Aspirin and its pleiotropic application

Jolanta Hybiak et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Neuroinflammation in pathogenesis of Alzheimer's disease: Phytochemicals as potential therapeutics

Alexander Vaiserman et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

添加到收藏夹

Review Endocrinology & Metabolism

The role of cellular senescence in ageing and endocrine disease

Sundeep Khosla et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

添加到收藏夹

Review Cell Biology

The Emerging Role of Senescence in Ocular Disease

Parameswaran G. Sreekumar et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Review Cell Biology

A Senescence-Centric View of Aging Implications for Longevity and Disease

M. Borghesan et al.

TRENDS IN CELL BIOLOGY (2020)

添加到收藏夹

Review Cell Biology

Senescence and the SASP: many therapeutic avenues

Jodie Birch et al.

GENES & DEVELOPMENT (2020)

添加到收藏夹

Review Geriatrics & Gerontology

Nanodelivery of phytobioactive compounds for treating aging-associated disorders

Oleh Lushchak et al.

GEROSCIENCE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Metformin Prevents H2O2-Induced Senescence in Human Lens Epithelial B3 Cells

Chunmei Zhang et al.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

Peter J. Thompson et al.

CELL METABOLISM (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Rhys Anderson et al.

EMBO JOURNAL (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The senescence-associated secretory phenotype and its regulation

Stephane Lopes-Paciencia et al.

CYTOKINE (2019)

添加到收藏夹

Review Physiology

CELLULAR SENESCENCE: AGING, CANCER, AND INJURY

Arianna Calcinotto et al.

PHYSIOLOGICAL REVIEWS (2019)

添加到收藏夹

Article Cell Biology

Targeting normal and cancer senescent cells as a strategy of senotherapy

Ewa Sikora et al.

AGEING RESEARCH REVIEWS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

CELL (2019)

添加到收藏夹

Article Cell Biology

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Mikolaj Ogrodnik et al.

CELL METABOLISM (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence

Mingxiao Feng et al.

FASEB BIOADVANCES (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2(-/-)) mice

Anja Moncsek et al.

HEPATOLOGY (2018)

添加到收藏夹

Article Geriatrics & Gerontology

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

Antonio Currais et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

添加到收藏夹

Article Cell Biology

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

Lucia Terlecki-Zaniewicz et al.

AGING-US (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Senolytics improve physical function and increase lifespan in old age

Ming Xu et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Cell Biology

Tau protein aggregation is associated with cellular senescence in the brain

Nicolas Musi et al.

AGING CELL (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ageing, Cellular Senescence and Neurodegenerative Disease

Marios Kritsilis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Tyler J. Bussian et al.

NATURE (2018)

添加到收藏夹

Article Oncology

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

Jin Pan et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr et al.

NATURE MEDICINE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Ok Hee Jeon et al.

NATURE MEDICINE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Cellular senescence mediates fibrotic pulmonary disease

Marissa J. Schafer et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Cellular senescence drives age-dependent hepatic steatosis

Mikolaj Ogrodnik et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article

Oncogenic senescence: a multi-functional perspective

Darren J. Baker et al.

Oncotarget (2017)

添加到收藏夹

Review Oncology

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

Markus Schosserer et al.

FRONTIERS IN ONCOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Marjolein P. Baar et al.

CELL (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular senescence and tumor promotion: Is aging the key?

Natalia Loaiza et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker et al.

NATURE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Bennett G. Childs et al.

SCIENCE (2016)

添加到收藏夹

Article Cell Biology

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu et al.

AGING CELL (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Bennett G. Childs et al.

NATURE MEDICINE (2015)

添加到收藏夹

Article Biology

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Ming Xu et al.

ELIFE (2015)

添加到收藏夹

Review Cell Biology

Metformin: From Mechanisms of Action to Therapies

Marc Foretz et al.

CELL METABOLISM (2014)

添加到收藏夹

Article Cell Biology

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Marco Demaria et al.

DEVELOPMENTAL CELL (2014)

添加到收藏夹

Review Multidisciplinary Sciences

The role of senescent cells in ageing

Jan M. van Deursen

NATURE (2014)

添加到收藏夹

Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

添加到收藏夹

Article Cell Biology

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-B activation

Olga Moiseeva et al.

AGING CELL (2013)

添加到收藏夹

Article Physiology

Increased expression of senescence markers in cystic fibrosis airways

Bernard M. Fischer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

添加到收藏夹

Article Geriatrics & Gerontology

Secretion of microvesicular miRNAs in cellular and organismal aging

Sylvia Weilner et al.

EXPERIMENTAL GERONTOLOGY (2013)

添加到收藏夹

Review Medicine, Research & Experimental

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tamara Tchkonia et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Metformin improves healthspan and lifespan in mice

Alejandro Martin-Montalvo et al.

NATURE COMMUNICATIONS (2013)

添加到收藏夹

Article Cell Biology

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

Anna C. Hearps et al.

AGING CELL (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

添加到收藏夹

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Cellular senescence in aging primates

U Herbig et al.

SCIENCE (2006)

添加到收藏夹

Review Geriatrics & Gerontology

Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease

JD Erusalimsky et al.

EXPERIMENTAL GERONTOLOGY (2005)

添加到收藏夹

Article Pharmacology & Pharmacy

Stress-induced premature senescence and tissue ageing

O Toussaint et al.

BIOCHEMICAL PHARMACOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.