期刊
VACCINES
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/vaccines11030578
关键词
lumpy skin disease virus; poxvirus; vaccine; recombination
Lumpy skin disease virus (LSDV) is a highly contagious virus that mainly infects cattle and buffalo and has spread from Africa to the Middle East, Europe, and Asia. The disease has a significant impact on the beef industry, causing mortality up to 10% and affecting milk and meat production as well as fertility. The use of live attenuated vaccines from related poxviruses has been implemented in some countries to protect against LSD, but the efficacy varies.
Lumpy skin disease virus (LSDV) is a member of the Capripoxvirus genus, mainly infecting cattle and buffalo, which until relatively recently was only endemic in parts of Africa and then spread to the Middle East and lately Europe and Asia. Lumpy skin disease (LSD) is a notifiable disease with a serious impact on the beef industry as it causes mortality of up to 10% and has impacts on milk and meat production, as well as fertility. The close serological relationship between LSDV, goat poxvirus (GTPV) and sheep poxvirus (SPPV) has led to live attenuated GTPV and SPPV vaccines being used to protect against LSD in some countries. There is evidence that the SPPV vaccine does not protect from LSD as well as the GTPV and LSDV vaccines. One of the LSD vaccines used in Eastern Europe was found to be a combination of different Capripoxviruses, and a series of recombination events in the manufacturing process resulted in cattle being vaccinated with a range of recombinant LSDVs resulting in virulent LSDV which spread throughout Asia. It is likely that LSD will become endemic throughout Asia as it will be very challenging to control the spread of the virus without widespread vaccination.
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