Vaccines against Tuberculosis: Where Are We Now?

Tuberculosis (TB) is among the top 10 leading causes of death in low-income countries. Statistically, TB kills more than 30,000 people each week and leads to more deaths than any other infectious disease, such as acquired immunodeficiency syndrome (AIDS) and malaria. TB treatment is largely dependent on BCG vaccination and impacted by the inefficacy of drugs, absence of advanced vaccines, misdiagnosis improper treatment, and social stigma. The BCG vaccine provides partial effectiveness in demographically distinct populations and the prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB incidences demands the design of novel TB vaccines. Various strategies have been employed to design vaccines against TB, such as: (a) The protein subunit vaccine; (b) The viral vector vaccine; (c) The inactivation of whole-cell vaccine, using related mycobacteria, (d) Recombinant BCG (rBCG) expressing Mycobacterium tuberculosis (M.tb) protein or some non-essential gene deleted BCG. There are, approximately, 19 vaccine candidates in different phases of clinical trials. In this article, we review the development of TB vaccines, their status and potential in the treatment of TB. Heterologous immune responses generated by advanced vaccines will contribute to long-lasting immunity and might protect us from both drug-sensitive and drug-resistant TB. Therefore, advanced vaccine candidates need to be identified and developed to boost the human immune system against TB.

Automated summary

Tuberculosis (TB) is a major cause of death, killing over 30,000 people per week and surpassing other infectious diseases like AIDS and malaria. TB treatment is affected by factors such as ineffective drugs, lack of advanced vaccines, misdiagnosis, improper treatment, and social stigma. Different vaccine strategies have been employed, including protein subunit vaccines, viral vector vaccines, whole-cell inactivation vaccines, and recombinant BCG vaccines. Currently, there are approximately 19 vaccine candidates in clinical trials. Advanced vaccines that generate heterologous immune responses are needed to enhance long-lasting immunity against both drug-sensitive and drug-resistant TB.