Polyethylene Glycol and Polysorbate 80 Skin Tests in the Context of an Allergic Risk Assessment for Hypersensitivity Reactions to Anti-SARS-CoV-2 mRNA Vaccines

Article

The role of skin tests with polyethylene glycol and polysorbate 80 in the vaccination campaign for COVID-19: results from an Italian multicenter survey

M.C. Montera et al.

European Annals of Allergy and Clinical Immunology (2023)

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Letter Allergy

Towards the best approach to PEG allergy

Francesco Marchi et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2022)

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Article Allergy

Allergy to polyethylene glycol and polysorbates in a patient cohort: Diagnostic work-up and decision points for vaccination during the COVID-19 pandemic

Charlotte G. Mortz et al.

Summary: During the COVID-19 pandemic, there is a potential risk for patients allergic to polyethylene glycol (PEG) and polysorbate to receive COVID-19 vaccines. However, after careful evaluation, most patients can be safely vaccinated with existing vaccines, while others may need to wait for vaccines with different excipients.

CLINICAL AND TRANSLATIONAL ALLERGY (2022)

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Article Allergy

Serum polyethylene glycol-specific IgE and IgG in patients with hypersensitivity to COVID-19 mRNA vaccines

Mariko Mouri et al.

Summary: The mechanism of allergic reactions to COVID-19 mRNA vaccines was investigated in this study. The results suggest that PEG and PS may play a role in causing allergic symptoms. Serum and skin samples from patients with immediate allergic reactions were tested, and higher levels of PEG-specific and PS-specific antibodies were found compared to the control group.

ALLERGOLOGY INTERNATIONAL (2022)

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Review Allergy

Polyethylene Glycol-Induced Systemic Allergic Reactions (Anaphylaxis)

Priya Sellaturay et al.

Summary: This study reports 5 cases of confirmed PEG allergy, with most cases related to medications containing PEGs. Skin tests showed positive reactions in 3 cases, with 2 cases experiencing allergic reactions following the intradermal test.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Allergy

Clinical manifestations and impact on daily life of allergy to polyethylene glycol (PEG) in ten patients

Maria A. Bruusgaard-Mouritsen et al.

Summary: Research findings indicate that most patients with PEG allergies have experienced severe allergic reactions, but these reactions did not recur after diagnosis. Diagnosis has a positive impact on patients' quality of life, but many patients experienced multiple reactions before being diagnosed.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

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Article Allergy

mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach

Aleena Banerji et al.

Summary: The FDA has authorized emergency use of Pfizer-BioNTech and Moderna COVID-19 vaccines, but individuals with severe allergic reactions are advised against receiving them. The CDC recommends observing those with a history of immediate allergies or anaphylaxis for 30 minutes post-vaccination, while all others should be observed for 15 minutes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Public, Environmental & Occupational Health

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021

et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Public, Environmental & Occupational Health

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine - United States, December 14-23, 2020

Tom Shimabukuro

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Review Immunology

Allergic Reactions to Current Available COVID-19 Vaccinations: Pathophysiology, Causality, and Therapeutic Considerations

Nicholas G. Kounis et al.

Summary: Vaccines are highly effective in public health, but can trigger allergic reactions, particularly severe ones that activate mast cells and lead to anaphylactic shock. Allergic reactions to vaccines are typically caused by excipients rather than the active vaccine itself.

VACCINES (2021)

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Article Immunology

Polyethylene glycol and polysorbate skin testing in the evaluation of coronavirus disease 2019 vaccine reactions

Mitchell M. Pitlick et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

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Letter Allergy

Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID-19 vaccine

Priya Sellaturay et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

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Article Allergy

Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy

Alexander Troelnikov et al.

Summary: Patients with a history of PEG allergy showed positive skin test results after receiving the BNT162b2 vaccine, while traditional PEG skin testing yielded negative results for 2 out of 3 patients. One patient exhibited cross-reactivity to PEG and polysorbate, leading to co-sensitization to both the BNT162b2 and AZD1222 vaccines.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Allergy to COVID-19 vaccines: A current update

Beatriz Cabanillas et al.

Summary: This passage discusses adverse allergic reactions to COVID-19 vaccines, with a focus on anaphylactic reactions following the administration of mRNA-1273 and BNT162b2 vaccines. It emphasizes the importance of avoiding vaccination for individuals with allergies to drugs or vaccine components.

ALLERGOLOGY INTERNATIONAL (2021)

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Article Allergy

Successful SARS-CoV-2 vaccine allergy risk management: The experience of a large Italian University Hospital

Giovanni Paoletti et al.

Summary: By implementing an allergy work-up protocol during the vaccination campaign, the number of patients avoiding SARS-CoV-2 vaccination due to allergies can be significantly reduced. This protocol effectively identifies and manages rare patients sensitized to PEGs and/or PS80.

WORLD ALLERGY ORGANIZATION JOURNAL (2021)

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Letter Allergy

Anaphylaxis to the first dose of mRNA SARS-CoV-2 vaccines: Don't give up on the second dose!

Matthew S. Krantz et al.

ALLERGY (2021)

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Editorial Material Medicine, General & Internal

COVID-19 and Kounis Syndrome: Deciphering Their Relationship

Nicholas G. Kounis et al.

BALKAN MEDICAL JOURNAL (2021)

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Article Allergy

First-Dose mRNA COVID-19 Vaccine Allergic Reactions: Limited Role for Excipient Skin Testing

Anna R. Wolfson et al.

Summary: Most patients with reported allergic reactions to the first dose of mRNA COVID-19 vaccines can safely receive the second dose after excipient skin testing, even if the results are positive. Some patients may require antihistamine medication or even epinephrine treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Letter Allergy