COVID-19 Vaccine Acceptance, Attitude and Perception among Slum and Underserved Communities: A Systematic Review and Meta-Analysis

This systematic review summarises the literature on Coronavirus Disease 2019 (COVID-19) vaccination, including acceptance, uptake, hesitancy, attitude and perceptions among slum and underserved communities. Relevant studies were searched from PubMed, Scopus, Web of Science and Google Scholar, following a pre-registered protocol in PROSPERO (CRD42022355101) and PRISMA guidelines. We extracted data, used random-effects models to combine the vaccine acceptance, hesitancy and uptake rates categorically, and performed meta-regression by R software (version 4.2.1). Twenty-four studies with 30,323 participants met the inclusion criteria. The overall prevalence was 58% (95% CI: 49-67%) for vaccine acceptance, 23% (95% CI: 13-39%) for uptake and 29% (95% CI: 18-43%) for hesitancy. Acceptance and uptake were positively associated with various sociodemographic factors, including older age, higher education level, male gender, ethnicity/race (e.g., Whites vs African Americans), more knowledge and a higher level of awareness of vaccines, but some studies reported inconsistent results. Safety and efficacy concerns, low-risk perception, long distance to vaccination centres and unfavourable vaccination schedules were prominent reasons for hesitancy. Moreover, varying levels of attitudes and perceptions regarding COVID-19 vaccination were reported with existing misconceptions and negative beliefs, and these were strong predictors of vaccination. Infodemic management and continuous vaccine education are needed to address existing misconceptions and negative beliefs, and this should target young, less-educated women and ethnic minorities. Considering mobile vaccination units to vaccinate people at home or workplaces would be a useful strategy in addressing access barriers and increasing vaccine uptake.

Automated summary

This systematic review summarises the literature on COVID-19 vaccination among slum and underserved communities. The review identified 24 relevant studies with over 30,000 participants. The acceptance rate for the vaccine was 58%, the uptake rate was 23%, and the hesitancy rate was 29%. Factors such as age, education level, gender, and ethnicity/race were associated with acceptance and uptake, although there were inconsistent results. Hesitancy was driven by safety and efficacy concerns, low-risk perception, distance to vaccination centers, and unfavorable vaccination schedules. Attitudes and perceptions towards COVID-19 vaccination varied, with existing misconceptions and negative beliefs acting as strong predictors of vaccination. The review highlights the need for infodemic management, continuous vaccine education, and targeted strategies for vulnerable populations.