New trends in pulmonary hypertension

Pulmonary hypertension (PH) is a prevalent disease of the pulmonary vasculature that is characterised by considerable morbidity and mortality. Substantial efforts have been made in recent years to improve disease recognition, diagnosis and management, and this is reflected in current guidelines. The haemodynamic definition of PH has been revised and a definition for exercise PH has been provided. Risk stratification has been refined and the importance of comorbidities and phenotyping have been highlighted. These changes provide an opportunity to potentially identify pulmonary vascular disease at an earlier stage and to enhance patient-centred, goal-orientated treatment decisions. A promising fourth treatment pathway for pulmonary arterial hypertension and potential targeted therapies for group 3 PH are on the horizon, concepts which seemed inconceivable only a few years ago. Beyond medication, there is a greater appreciation for the importance of supervised training in stable PH and the possible role of interventional therapies in select cases. The landscape of PH is changing and it is characterised by progress, innovation and opportunities. In this article, we highlight some of the new trends in PH, with a specific focus on the revised European Society of Cardiology/European Respiratory Society 2022 guidelines for the diagnosis and management of PH.

Automated summary

Pulmonary hypertension is a prevalent disease with high morbidity and mortality. Efforts have been made to improve disease recognition, diagnosis, and management, reflected in the updated guidelines. Changes in the definition, risk stratification, and emphasis on comorbidities and phenotyping provide new opportunities for early identification and patient-centered treatment decisions. New treatment pathways and potential targeted therapies are emerging, along with the recognition of the importance of supervised training and interventional therapies. This article highlights the trends in pulmonary hypertension, focusing on the revised guidelines.