Glutamine coated titanium for synergistic sonodynamic and photothermal on tumor therapy upon targeted delivery

Article Pediatrics

CCL3 aggravates intestinal damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization

Xi Yuan et al.

Summary: This study found that high expression of CCL3 in the intestinal tissue of NEC patients promoted macrophage infiltration and inflammatory damage, and inhibiting CCL3 could alleviate the development of NEC.

PEDIATRIC RESEARCH (2023)

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Review Pharmacology & Pharmacy

Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Chaithanya Ganji et al.

Summary: Mitochondria, as the powerhouses of cells, play important roles in cellular survival through regulating essential metabolic functions. Dysregulation of mitochondrial pathways, such as oxidative phosphorylation or production of reactive oxygen species (ROS), has been identified in cancer growth and development, making them attractive targets against cancer. Recent advances in nanotechnology have provided innovative solutions for delivering antitumor agents to mitochondria. This review explores the importance of mitochondria in neoplastic development, discusses the latest smart designs of nano-based systems for targeting mitochondria, and highlights key mitochondrial pathways in cancer cells.

DRUG DISCOVERY TODAY (2023)

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Review Oncology

Review of Therapies using TiO2 Nanomaterials for Increased Anticancer Capability

Noe Rodriguez-Barajas et al.

Summary: Titanium dioxide nanoparticles have shown remarkable potential as a viable anticancer treatment strategy when combined with activation therapies such as photodynamic therapy, photothermal therapy, sonodynamic therapy, and ultraviolet therapy. These therapies enhance the killing of cancer cells through the formation of reactive oxygen species. However, more studies are needed to ensure the safe use of this therapy under different experimental conditions.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2022)

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Review Biochemical Research Methods

Diverse biotechnological applications of multifunctional titanium dioxide nanoparticles: An up-to-date review

Rabia Javed et al.

Summary: Titanium dioxide nanoparticles (TiO2 NPs) are widely used metallic oxide nanoparticles. Doping can improve the properties of the nanoparticles and have significant effects in the field of biotechnology. The exponential growth of research on TiO2 NPs is due to their chemical stability, low toxicity, and multifaceted properties. They are extensively used in agriculture, environmental remediation, and nanomedicine.

IET NANOBIOTECHNOLOGY (2022)

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Article Oncology

Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells

Mohammed Salah et al.

Summary: This study found that titanium peroxide nanoparticles combined with radiation have anti-cancer effects on radioresistant pancreatic cancer stem cells (CSCs). They can inhibit the proliferation and invasion abilities of CSCs, and suppress the growth of pancreatic tumors by generating reactive oxygen species (ROS). These findings suggest that the combination of TiOxNPs and radiation may be an effective therapeutic strategy for pancreatic CSCs.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Macrophage-Targeted Sonodynamic/Photothermal Synergistic Therapy for Preventing Atherosclerotic Plaque Progression Using CuS/TiO2 Heterostructured Nanosheets

Zhengyu Cao et al.

Summary: Sonodynamic therapy (SDT) and photothermal therapy (PTT) are combined using hyaluronic acid and PEG-modified copper sulfide/titanium oxide heterostructure nanosheets to target and treat early atherosclerotic plaques. The synergistic therapy induces apoptosis of proinflammatory macrophages, reduces heat shock protein 90 expression, and mitigates inflammation, preventing plaque progression.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Platinum-Titania Schottky Junction as Nanosonosensitizer, Glucose Scavenger, and Tumor Microenvironment-Modulator for Promoted Cancer Treatment

Yinmin Zhao et al.

Summary: The construction of a smart therapeutic nanoplatform consisting of TiO2@Pt/GOx (TPG) allows for efficient sonodynamic therapy (SDT) and starvation therapy (ST), which lead to systemic tumor suppression and hypoxia alleviation in the tumor microenvironment. The optimized energy structure of TPG enables rapid generation of singlet oxygen and hydroxyl radicals. The accumulation of reactive oxygen species and glucose depletion facilitated by TPG result in oxidative damage and energy exhaustion of cancer cells, amplified by Pt-catalyzed oxygen self-supply. The combinatorial therapy also triggers immunogenetic cell death and subsequent suppression of distant tumors and metastasis through antitumor immunity.

ACS NANO (2022)

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Article Cell Biology

Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction

Bailing Wei et al.

Summary: This study identified a new mechanism for the antiangiogenic effect of Brevilin A (BA) in regulating endothelial cell angiogenesis, which is based on the regulation of mitochondrial-dependent ROS overproduction.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Microbiology

Multiple Photolyases Protect the Marine Cyanobacterium Synechococcus from Ultraviolet Radiation

Allissa M. Haney et al.

Summary: By analyzing the genomes of marine cyanobacteria, researchers have identified multiple photolyase genes that play a crucial role in the survival of these organisms in UV-rich waters. The study also highlights the importance of photolyases in DNA repair.

MBIO (2022)

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Article Pharmacology & Pharmacy

Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy

Zekun Li et al.

Summary: NIR-light-triggered nanomedicine, including PDT and PTT, is an attractive approach for cancer therapy due to its controllability and minimal invasion. A tumor-microenvironment responsive CRISPR nanoplatform based on oxygen-deficient titania has been developed for mild NIR-phototherapy. In the tumor microenvironment, the overexpressed HAase and GSH can destroy HA and disulfide bond, releasing Cas9/sgRNA to target stress alleviating regulators and reduce stress tolerance of tumor cells. Under NIR light, the TiO2 exhibits a higher anticancer effect.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Chemistry, Multidisciplinary

UV-irradiating synthesis of cyclodextrin-silver nanocluster decorated TiO2 nanoparticles for photocatalytic enhanced anticancer effect on HeLa cancer cells

Hongying Wang et al.

Summary: Titanium dioxide nanoparticles decorated with ultrasmall silver nanoparticles and per-6-thio-beta-cyclodextrin showed superior cytotoxic effects on HeLa cancer cells, indicating their potential as a promising material for biological applications. The combination of silver core, cyclodextrin ligands, and titanium dioxide nanoparticles produced a synergistic anticancer effect.

FRONTIERS IN CHEMISTRY (2022)

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Article Medicine, Research & Experimental

Self-immolative nanosensitizer for glutathione depletion- assisted sonodynamic therapy

Chan Ho Kim et al.

Summary: In this study, a novel nanosensitizer decorated with hydrophilized self-immolative polymer on TiO2 nanoparticles was reported for enhanced sonodynamic therapy. By reprogramming cancer cells, this nanosensitizer effectively inhibited tumor growth in mice through the synergistic effects of glutathione depletion and reactive oxygen species generation.

THERANOSTICS (2022)

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Article Materials Science, Biomaterials

Oxygen-deficient titanium dioxide-loaded black phosphorus nanosheets for synergistic photothermal and sonodynamic cancer therapy

Wenxiang Du et al.

Summary: The study successfully constructed a dual-functional nanocomposite for combined photothermal/sonodynamic therapy using black titanium dioxide and black phosphorus nanosheets. The nanocomposite exhibits a high photothermal conversion capability and the ability to produce reactive oxygen species, leading to effective tumor inhibition.

BIOMATERIALS ADVANCES (2022)

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Article Biochemistry & Molecular Biology

Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo

Xinyue Liang et al.

Summary: The study presents a novel photosensitizer FA-TiO2-Pc with high targeted photodynamic therapeutic activity and excellent biocompatibility, showing great potential for treatment of folate receptor positive cancer cells.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2021)

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Article Nanoscience & Nanotechnology