☆ 4.7 Review

Bioprospecting microbes and enzymes for the production of pterocarpans and coumestans

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Summary: Carbon dioxide is the main greenhouse gas and a critical issue for global warming and climate change. Microalgae, which are inconspicuous microorganisms, account for 40% of carbon fixation in photosynthetic plants and have higher photosynthetic efficiency. They convert carbon into various useful compounds. Genetic engineering and metabolic engineering are used to increase the growth rate and biomass of microalgae to achieve carbon neutrality. CRISPR/Cas9 is an efficient tool to enhance productivity in microalgae by regulating multiple genes simultaneously. This review summarizes the technologies, bioinformatics tools, and systematic engineering approaches for carbon neutrality and circular economy, bringing us closer to a decarbonized society.

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