Lipoaspirate fluid derived factors and extracellular vesicles accelerate wound healing in a rat burn model

Review Dermatology

Therapeutic potential of adipose tissue-derivatives in modern dermatology

Barbara Bellei et al.

Summary: Stem cell-mediated therapies in regenerative medicine, particularly using adipose-derived stem cells and their secretome, have shown promising results in treating various skin disorders.

EXPERIMENTAL DERMATOLOGY (2022)

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Article Cell & Tissue Engineering

Cell-free fat extract attenuates osteoarthritis via chondrocytes regeneration and macrophages immunomodulation

Zhuoxuan Jia et al.

Summary: The study found that CEFFE (a cell-free fat extract containing multiple cytokines) inhibits the progression of osteoarthritis by promoting cartilage regeneration and limiting joint inflammation.

STEM CELL RESEARCH & THERAPY (2022)

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Article Cell & Tissue Engineering

Comparison of two cell-free therapeutics derived from adipose tissue: small extracellular vesicles versus conditioned medium

Chuan He et al.

Summary: Our study compared adipose tissue extract (ATE) and its further purified small extracellular vesicles (sEV-AT) in terms of characteristics, inductivity on cells, and capacity for promoting de novo adipose tissue regeneration. sEV-AT showed higher particle yield and concentrated particle size distribution, while ATE had more soluble factors and multiple peaks in particle size distribution.

STEM CELL RESEARCH & THERAPY (2022)

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Article Cell Biology

Effects of Adipose-Derived Stem Cells and Their Conditioned Medium in a Human Ex Vivo Wound Model

Xiao Guo et al.

Summary: This study used ex vivo human skin cultured as a model for superficial wounds to investigate the effects of adipose-derived stem cells (ASCs) on wound healing. The results showed that ASCs promoted re-epithelialization and vascularization, and modulated the inflammatory immune response. The expression of inflammatory mediators and growth factors varied depending on the treatment, indicating that the wound microenvironment can influence the secreted mediators and the mode of action of ASCs in wound healing.

CELLS (2022)

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Review Cell & Tissue Engineering

Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration

Jia-Chen Hu et al.

Summary: Poor healing of cutaneous wounds is a common medical problem. Recent evidence suggests that MSC-exosomes have therapeutic potentials in wound healing through various mechanisms. Therefore, MSC-exosomes could be a promising alternative for the treatment of cutaneous wounds.

WORLD JOURNAL OF STEM CELLS (2022)

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Article Biotechnology & Applied Microbiology

Isolation of Extracellular Vesicles From Microalgae: A Renewable and Scalable Bioprocess

Angela Paterna et al.

Summary: This study focuses on the production of nanoalgosomes from marine microalgae and optimizes the technical parameters and conditions to improve yield and purity. The feasibility of recycling microalgae cells for multiple production cycles post-EVs isolation is also explored. The results demonstrate the potential of nanoalgosome production for diverse scientific and industrial applications.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Medicine, General & Internal

The Therapeutic Role of ADSC-EVs in Skin Regeneration

Yixi Wang et al.

Summary: Adipose-derived stem cells (ADSCs) play a crucial role in skin regeneration through their secreted extracellular vesicles (ADSC-EVs). ADSC-EVs accelerate skin regeneration by modulating mechanisms such as inflammation, angiogenesis, cell proliferation, extracellular matrix (ECM) remodeling, autophagy, and oxidative stress, and they also stimulate hair follicle regeneration and skin barrier repair.

FRONTIERS IN MEDICINE (2022)

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Article Cell & Tissue Engineering

Research update of adipose tissue-based therapies in regenerative dermatology

Barbara Bellei et al.

Summary: Mesenchymal stromal/stem cells (MSCs), especially adipose-derived tissue stem cells (ADSCs), have significant applications in skin regenerative medicine. ADSCs have secretory activity that promotes tissue repair, and adipose tissue derivatives are also being studied for treating skin diseases.

STEM CELL REVIEWS AND REPORTS (2022)

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Review Cell & Tissue Engineering

Application of ADSCs and their Exosomes in Scar Prevention

Cong Li et al.

Summary: Scar is a common way of healing after tissue injury, but the process of scar formation is complex and not fully understood. Fibroblasts and myofibroblasts play important roles in wound healing and scar formation, while adipose tissue-derived stem cells and their exosomes also have an impact on it.

STEM CELL REVIEWS AND REPORTS (2022)

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Review Chemistry, Medicinal

Extracellular Vesicles in Skin Wound Healing

Deimante Narauskaite et al.

Summary: Extracellular vesicles (EVs) play a crucial role in wound healing and potential therapeutic interventions. In addition to their natural healing capacity, EVs can be engineered to carry specific cargo for targeted pharmaceutical purposes, making them a promising treatment modality.

PHARMACEUTICALS (2021)

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Article Immunology

Preparation and characterization of extracellular vesicles

Swasti Tiwari et al.

Summary: Extracellular vesicles (EVs) are membranous vesicles secreted by cells with significant potential in therapy and diagnostics. Various methods, such as ultracentrifugation and biochemical analyses, are used for isolation and characterization of EVs, but limitations exist in each method. Evolving concepts in EV biology hold promise for better isolation and characterization methods, with great clinical implications.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)

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Review Engineering, Biomedical

Extracellular vesicles: A bright star of nanomedicine

Peipei Wu et al.

Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.

BIOMATERIALS (2021)

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Review Pharmacology & Pharmacy

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

Anika Nagelkerke et al.

Summary: Extracellular vesicles (EVs) are biological nanoparticles secreted by cells that act as delivery vehicles for molecular messages, showing potential as therapeutic mediators for various diseases. EVs have regenerative properties and can mediate signaling cascades in target cells to achieve functional outcomes in tissue repair and regeneration. Their interactions and biodistribution in vivo, especially when combined with biomaterials, influence their regenerative effects, with progress being made towards successful implementation of EV regenerative therapies in a clinical setting.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Multidisciplinary Sciences

Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

Chen Hu et al.

Summary: The study demonstrated that the structural properties of biomaterials can influence cell behavior and immune responses, with electrospun membranes of different surface topographies affecting wound healing and immunomodulatory properties. Single-cell RNA sequencing revealed diverse immune cell heterogeneity in vivo, and the aligned scaffold accelerated the immune response towards an adaptive immunity-dominant stage. The microenvironment around scaffolds exhibited intricate interactions between immune and cutaneous cells.

SCIENCE ADVANCES (2021)

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Review Medicine, General & Internal

A Narrative Review of the History of Skin Grafting in Burn Care

Deepak K. Ozhathil et al.

Summary: Skin grafting has evolved from ancient necessity to a precise tool in modern medicine, experiencing fluctuations in popularity throughout history. Advancements in surgical instruments and skin substitutes have improved outcomes and expanded the practice to a wider range of medical professionals, leading to the development of more advanced tissue engineering techniques.

MEDICINA-LITHUANIA (2021)

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Article Public, Environmental & Occupational Health

Epidemiology of injuries from fire, heat and hot substances: global, regional and national morbidity and mortality estimates from the Global Burden of Disease 2017 study

Spencer L. James et al.

INJURY PREVENTION (2020)

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Review Biochemistry & Molecular Biology

Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing

Loubna Mazini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Engineering, Biomedical

Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury

Yixiao Dong et al.

ACTA BIOMATERIALIA (2020)

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Review Cell & Tissue Engineering

Therapeutic applications of adipose cell-free derivatives: a review

Yuan Cai et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Chemistry, Multidisciplinary

Chronic wounds: Current status, available strategies and emerging therapeutic solutions

Kevin Las Heras et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Surgery

Fat Injection for Cases of Severe Burn Outcomes: A New Perspective of Scar Remodeling and Reduction

M. Klinger et al.

AESTHETIC PLASTIC SURGERY (2020)

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Review Emergency Medicine

Vascularization is the next challenge for skin tissue engineering as a solution for burn management

Hady Shahin et al.

BURNS & TRAUMA (2020)

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Article Orthopedics

Exosomes Isolated From Adipose-Derived Stem Cells: A New Cell-Free Approach to Prevent the Muscle Degeneration Associated With Torn Rotator Cuffs

Chongyang Wang et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2019)

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Article Cell & Tissue Engineering

Multiple Injections of Autologous Adipose-Derived Stem Cells Accelerate the Burn Wound Healing Process and Promote Blood Vessel Regeneration in a Rat Model

Xiaolong Zhou et al.

STEM CELLS AND DEVELOPMENT (2019)

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Article Cell Biology

Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis

Peng Wei et al.

CELL DEATH & DISEASE (2019)

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Article Cell & Tissue Engineering

Human adipose liquid extract induces angiogenesis and adipogenesis: a novel cell-free therapeutic agent

Yunfan He et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Cell Biology

Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing

Jiyoon Ryu et al.

CELLS (2019)

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Article Critical Care Medicine

Epidemiology and outcomes of burn injuries at a tertiary burn care center in Bangladesh

M. E. Bailey et al.

BURNS (2019)

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Article Engineering, Biomedical

Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model

Christophe O. Chantre et al.

BIOMATERIALS (2018)

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Review Cell & Tissue Engineering

The limited application of stem cells in medicine: a review

Jordan Poulos

STEM CELL RESEARCH & THERAPY (2018)

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Article Biotechnology & Applied Microbiology

Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

Reka Agnes Haraszti et al.

MOLECULAR THERAPY (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Oncology

MicroRNA-185 regulates transforming growth factor-β1 and collagen-1 in hypertrophic scar fibroblasts

Kaiyan Xiao et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Multidisciplinary Sciences

Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling

Lu Wang et al.

SCIENTIFIC REPORTS (2017)

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Article Chemistry, Physical

Cerium Chloride Application Promotes Wound Healing and Cell Proliferation in Human Foreskin Fibroblasts

Liza L. Ramenzoni et al.

MATERIALS (2017)

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Review Emergency Medicine

Current progress in understanding the molecular pathogenesis of burn scar contracture

Jianglin Tan et al.

BURNS & TRAUMA (2017)

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Review Cardiac & Cardiovascular Systems

Methodological Guidelines to Study Extracellular Vesicles

Frank A. W. Coumans et al.

CIRCULATION RESEARCH (2017)

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Article Critical Care Medicine

Analyzing contraction of full thickness skin grafts in time: Choosing the donor site does matter

Carlijn M. Stekelenburg et al.

BURNS (2016)

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Article Dermatology

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Philippe Foubert et al.

ADVANCES IN WOUND CARE (2016)

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Article Biotechnology & Applied Microbiology

Overcoming immunological barriers in regenerative medicine

Johannes L. Zakrzewski et al.

NATURE BIOTECHNOLOGY (2014)

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Article Dermatology

Wound healing and the role of fibroblasts

Bainbridge P.

Journal of Wound Care (2014)

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Article Agriculture, Multidisciplinary

Bovine Milk Fat Globule Membrane Proteins Are Affected By Centrifugal Washing Processes

Haotian Zheng et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

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Review Oncology

The tumorigenicity of human embryonic and induced pluripotent stem cells

Uri Ben-David et al.

NATURE REVIEWS CANCER (2011)

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Review Immunology

Adipokines in inflammation and metabolic disease

Noriyuki Ouchi et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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Article Surgery

Fat injection for cases of severe burn outcomes: A new perspective of scar remodeling and reduction

M. Klinger et al.

AESTHETIC PLASTIC SURGERY (2008)

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Article Biophysics

Nonlinear flow affects hydrodynamic forces and neutrophil adhesion rates in cone-plate viscometers

H Shankaran et al.

BIOPHYSICAL JOURNAL (2001)

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Lipoaspirate fluid derived factors and extracellular vesicles accelerate wound healing in a rat burn model

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