期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2023.1184159
关键词
neonatal necrotizing enterocolitis; Paneth cells; gut microbiota; intestinal stem cells; necroptosis; apoptosis; pyroptosis
This review summarizes the features of Paneth cells, including their immune function, association with gut microbiota and intestinal stem cells, and their mechanism of regulating intestinal epithelial cell death, in order to explore the possible mechanisms by which Paneth cells affect necrotizing enterocolitis (NEC).
Paneth cells (PCs) are intestinal epithelial cells (IECs) that contain eosinophilic granules, which are located in Lieberkuhn crypts. An increasing number of animal and human experiments have indicated that PCs are involved in the progression of a variety of intestinal as well as systemic inflammatory responses including necrotizing enterocolitis (NEC). NEC is an enteric acquired disease with high mortality that usually occurs in premature infants and neonates, however the underlying mechanisms remain unclear. In this review, we summarize the features of PCs, including their immune function, association with gut microbiota and intestinal stem cells, and their mechanism of regulating IEC death to explore the possible mechanisms by which PCs affect NEC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据