4.7 Article

KATP channels are necessary for glucose- dependent increases in amyloid-β and Alzheimer's disease-related pathology

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Summary: GABAergic signaling plays a crucial role in the inhibitory stabilization and coordination of excitatory neurons in mature cortical circuits. This review examines how GABA-releasing interneurons acquire their network functions during development, focusing on the visual neocortex and hippocampus in mice and rats. The authors propose that inhibitory stabilization is not functional at the onset of patterned activity, and that glutamatergic neurons are stable by themselves. The strengthening of inhibitory synaptic transmission toward eye opening shapes cortical network dynamics and allows the developing cortex to disengage from extra-cortical synaptic drive. The framework presented in this review has implications for our understanding of human cortical development and the treatment of neonatal seizures.

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