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Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease

GEROSCIENCE (2023)

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Review Clinical Neurology

Effects of physical activity and exercise interventions on Alzheimer's disease: an umbrella review of existing meta-analyses

Susana Lopez-Ortiz et al.

Summary: The study summarizes the relationship between physical activity and the development of Alzheimer's disease, as well as the impact of exercise on patients with Alzheimer's disease. The findings suggest that physical activity can lower the risk of Alzheimer's disease and exercise has positive effects on cognitive function, physical performance, and functional independence.

JOURNAL OF NEUROLOGY (2023)

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Article Cell Biology

Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction

Cara L. Green et al.

Summary: Research has found that the improvement of metabolic health through reduced dietary protein strongly depends on sex and strain. While some phenotypes remain consistent across different strains and sexes, there is high variability in adiposity, insulin sensitivity, and circulating hormones.

CELL METABOLISM (2022)

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Article Neurosciences

JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model

Jessica L. Dennison et al.

Summary: JOTROL, a novel oral formulation of resveratrol, has higher bioavailability compared to non-formulated resveratrol. It has been found to be effective in the prevention and treatment of AD by regulating AD-related gene expression, inhibiting inflammatory genes, and regulating cytokine levels.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Article Neurosciences

Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease

Steven G. Fagan et al.

Summary: This study demonstrates that fingolimod may be a potential multimodal therapeutic for Alzheimer's disease, as it can reverse deficits in spatial working memory, alleviate inflammation in the brain, and reduce tau and APP levels in key brain regions.

MOLECULAR NEUROBIOLOGY (2022)

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Article Neurosciences

The effect of exercise on early sensorimotor performance alterations in the 3xTg-AD model of Alzheimer's disease

Sonja K. Bareiss et al.

Summary: Alzheimer's disease is associated with a decline in cognitive function as well as non-cognitive sensorimotor and psychomotor symptoms. While exercise is believed to be beneficial for AD, its effect on sensorimotor functions is not well understood. In this study, researchers found that exercise can improve sensorimotor function and reduce abnormal behavior in a mouse model of AD.

NEUROSCIENCE RESEARCH (2022)

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Article Cell Biology

Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer's Disease

Sudhir Kshirsagar et al.

Summary: The purpose of this study is to investigate the early cellular, molecular, morphological, and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. The findings suggest that amyloid-beta is sufficient to cause behavioral, mitochondrial, synaptic, and ultrastructural changes in mice.

CELLS (2022)

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Editorial Material Geriatrics & Gerontology

Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49th Annual Meeting of the American Aging Association

Michaela E. Murphy et al.

GEROSCIENCE (2022)

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Review Cell Biology

The central moTOR of metabolism

Judith Simcox et al.

Summary: This review discusses the importance of protein kinase mechanistic target of rapamycin (mTOR) in metabolic regulation, its role in regulating the metabolism of the four macromolecular building blocks of the cell, and its impact on organismal physiology and aging. It also explores the potential clinical application of mTOR inhibitors in the treatment and prevention of age-related diseases.

DEVELOPMENTAL CELL (2022)

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Article Geriatrics & Gerontology

Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle

Melissa C. Orenduff et al.

Summary: Aging is a complex process that involves the progressive deterioration of physiological integrity and function. Loss of muscle mass, strength, and function, known as sarcopenia, is one of the major contributors to the harmful effects of aging. Calorie restriction (CR) has been shown to extend lifespan and delay the onset and progression of age-related diseases, including sarcopenia. Rapamycin, a pharmacological compound, has demonstrated similar longevity benefits without the need for dietary restrictions. In our study, we found that both CR and rapamycin can partially protect against age-related muscle decline, but they engage different molecular pathways in skeletal muscle. The therapeutic potential of rapamycin or a CR regimen in preventing and managing sarcopenia should be further explored in translational studies.

EXPERIMENTAL GERONTOLOGY (2022)

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Review Biochemistry & Molecular Biology

Antidiabetic Drugs in the Treatment of Alzheimer's Disease

Michalis Michailidis et al.

Summary: The public health burden of type 2 diabetes mellitus and Alzheimer's disease is increasing, especially in older adults. Recent studies have found that certain antidiabetic medications can improve cognition and memory in patients with Alzheimer's disease. This review examines the latest evidence for the potential use of antidiabetic medications in treating Alzheimer's disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cell Biology

Molecular mechanisms of dietary restriction promoting health and longevity

Cara L. Green et al.

Summary: Dietary restriction with adequate nutrition is considered the gold standard for delaying ageing and extending healthspan and lifespan in various species, as it impacts key nutrient-sensing signalling pathways to promote healthy longevity.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Neurosciences

Impaired insulin signalling and allostatic load in Alzheimer disease

Fernanda G. De Felice et al.

Summary: This review discusses the role of impaired insulin signalling and allostatic load in Alzheimer's disease (AD) and highlights the potential of social and lifestyle interventions in preserving brain health and preventing AD.

NATURE REVIEWS NEUROSCIENCE (2022)

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Article Multidisciplinary Sciences

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

Daniel J. Ham et al.

Summary: The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. However, this study showed that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

Cristal M. Hill et al.

Summary: Restriction of dietary protein can extend the lifespan and improve metabolic health in mice, and the endocrine hormone FGF21 is essential for the anti-aging effect of this dietary intervention.

NATURE COMMUNICATIONS (2022)

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Review Clinical Neurology

Glucose metabolism and AD: evidence for a potential diabetes type 3

Andrea Gonzalez et al.

Summary: This study explores the influence of glucose metabolism on Alzheimer's disease from three different perspectives, including its role as a regulator of energy source, its impact on immune system activation through metabolic abnormalities, and its regulation of post-translational modifications in key proteins. The findings support the hypothesis that AD is a new type of diabetes.

ALZHEIMERS RESEARCH & THERAPY (2022)

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Article Endocrinology & Metabolism

Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle

Christopher A. Bishop et al.

Summary: This study investigates the roles of branched-chain amino acids (BCAA) in metabolic health and finds that leucine has beneficial effects on adiposity and insulin sensitivity, while valine intake worsens glucose tolerance and insulin sensitivity.

NUTRITION & DIABETES (2022)

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Review Neurosciences

Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond

Chenghuan Song et al.

Summary: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. The failure of AD drug development is mainly due to discrepancies in understanding the disease mechanism, but ongoing studies provide new avenues for unraveling disease mechanisms and guiding drug development. Immunotherapeutic strategies targeting amyloid-beta (Aβ) and tau proteins were once considered effective, but the repeated failures of clinical trials have raised doubts. However, the recent approval of a new anti-Aβ monoclonal antibody renews hope in immunotherapy strategies targeting Aβ. Other immunotherapeutic strategies targeting tau, microglia, and the gut-brain axis are also under development.

TRANSLATIONAL NEURODEGENERATION (2022)

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Article Multidisciplinary Sciences

[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease

Tharick A. Pascoal et al.

Summary: Alzheimer's disease is characterized by the accumulation of amyloid-beta and tau proteins in the brain. Epigenetic dysregulation has been found to play a role in the interaction between these protein abnormalities, neurodegeneration, and cognitive impairment.

NATURE COMMUNICATIONS (2022)

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Review Plant Sciences

Regulation of Gene Expression through Food-Curcumin as a Sirtuin Activity Modulator

Anca Ungurianu et al.

Summary: The sirtuin family plays a crucial role in regulating various physiological functions, and can have beneficial effects through modulating their activity. Curcumin and its metabolites are considered effective molecules in regulating sirtuin activity, and have antioxidant, anti-inflammatory, and anticancer properties.

PLANTS-BASEL (2022)

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Article Clinical Neurology

Effectiveness of motor-cognitive dual-task exercise via telerehabilitation in Alzheimer's disease: An online pilot randomized controlled study.

Kubra Nur Menengic et al.

Summary: This study investigated the effectiveness of home-based telerehabilitation (TR) in treating Alzheimer's disease (AD). The results showed that TR may significantly improve cognition and mobility, enhance functional independence, and reduce anxiety and depressive symptoms in AD patients.

CLINICAL NEUROLOGY AND NEUROSURGERY (2022)

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Article Medicine, General & Internal

Safety and efficacy of plasma transfusion from exercise-trained donors in patients with early Alzheimer's disease: protocol for the ExPlas study

Atefe R. Tari et al.

Summary: This study aims to test the safety and tolerability of transfusing exercised plasma to patients with mild cognitive impairment or early Alzheimer's disease, and examine its effects on cognitive function, fitness level, cerebral blood flow, and biomarkers.

BMJ OPEN (2022)

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Article Cell Biology

Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models

Priya Rangan et al.

Summary: The research suggests that fasting-mimicking diet cycles can help reduce cognitive decline and Alzheimer's disease pathology, with effects superior to protein restriction cycles. By reducing neuroinflammation and superoxide production, it delays cognitive decline in AD models.

CELL REPORTS (2022)

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Review Pharmacology & Pharmacy

Therapeutic insights elaborating the potential of retinoids in Alzheimer's disease

Tapan Behl et al.

Summary: Alzheimer's disease is a complex neurodegenerative disorder characterized by various pathological processes, including disrupted retinoid signaling. Retinoids are involved in the immune function and play critical roles in the normal functioning of the nervous system. Disturbed retinoid signaling can lead to inflammation, oxidative stress, and neurodegeneration, contributing to the progression of Alzheimer's disease.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Multidisciplinary Sciences

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna

Anastasia Shindyapina et al.

Summary: This study found that exposure to rapamycin during development can extend lifespan and reduce body size in mice and water fleas. By slowing down development and aging, rapamycin effectively preserves health and extends lifespan.

SCIENCE ADVANCES (2022)

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Review Immunology

Immunotherapies for Alzheimer's Disease-A Review

Zachary Valiukas et al.

Summary: Alzheimer's disease is a chronic neurodegenerative disorder characterized by the presence of toxic substances in the brain. Traditional drug treatments have limitations, leading to the exploration of immunotherapies, which target the production and deposition of these substances.

VACCINES (2022)

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Article Biochemistry & Molecular Biology

Nicotinamide riboside ameliorates high-fructose-induced lipid metabolism disorder in mice via improving FGF21 resistance in the liver and white adipose tissue

Hui Zhao et al.

Summary: This study found that NR supplementation can improve high-fructose-induced lipid metabolism disorder by improving FGF21 resistance in the liver and WAT, which may be related to the regulation of inflammation mediated by the SIRT1/NF-kappa B signaling pathway.

FOOD & FUNCTION (2022)

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Article Chemistry, Medicinal

Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice

Nada El-Megiri et al.

Summary: The present study aimed to investigate the potential neuroprotective effect of Pioglitazone in PTZ kindled seizure in mice. Treatment with Pioglitazone demonstrated a significant decrease in NGF, seizure score, m-TOR, GLUT-1 and GLUT-3 in comparison to the PTZ group, suggesting that Pioglitazone provides its neuroprotective effect through modulating m-TOR signaling, glucose metabolism and NGF levels.

PHARMACEUTICALS (2022)

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Article Nutrition & Dietetics

Long-term dietary protein intake and subjective cognitive decline in US men and women

Tian-Shin Yeh et al.

Summary: This study revealed that higher protein intake, especially when compared to carbohydrates, was associated with lower odds of subjective cognitive decline. Plant protein sources were also found to be beneficial in reducing the risk of cognitive decline compared to animal protein sources.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)

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Article Hospitality, Leisure, Sport & Tourism

Inter-individual differences in the responses to aerobic exercise in Alzheimer's disease: Findings from the FIT-AD trial

Fang Yu et al.

Summary: Inter-individual differences in aerobic fitness and cognitive responses to aerobic exercise were found in older adults with mild-to-moderate dementia due to AD, highlighting the potential impact on treatment outcomes.

JOURNAL OF SPORT AND HEALTH SCIENCE (2021)

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Review Cell Biology

Exercise interventions in Alzheimer's disease: A systematic review and meta-analysis of randomized controlled trials

Susana Lopez-Ortiz et al.

Summary: This study systematically evaluated the effects of exercise interventions on patients with Alzheimer's disease in terms of cognitive function, physical function, functional independence, and neuropsychiatric symptoms. The results suggest that exercise interventions can have significant benefits in multiple domains for patients with AD.

AGEING RESEARCH REVIEWS (2021)

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Article Neurosciences

Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies

Essi F. Biyong et al.

Summary: Vitamin A is critical for maintaining memory function with advancing age, and impaired brain Vitamin A signaling may contribute to the onset of Alzheimer's disease. A study found that chronic exposure of 3xTg-AD mice to a Vitamin A-enriched diet may be protective in males but not in females.

NEUROBIOLOGY OF DISEASE (2021)

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Article Neurosciences

Cognitive Effects of Aerobic Exercise in Alzheimer's Disease: A Pilot Randomized Controlled Trial

Fang Yu et al.

Summary: The study found that for older adults with mild-to-moderate Alzheimer's disease, exercise may help reduce the decline in global cognition. However, aerobic exercise did not show superior cognitive effects compared to stretching, possibly due to the lack of power in the pilot trial.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Review Biochemistry & Molecular Biology

The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis

Giuseppe Caruso et al.

Summary: Carnosine, proposed as an anti-aging agent over 20 years ago, has shown antioxidant, anti-inflammatory, and anti-aggregation activity with neuroprotective effects in animal models of Alzheimer's disease. Global cognitive function was improved after 12 weeks of carnosine/anserine supplementation at a dose of 1 g/day in elderly subjects, while no effects were observed on depressive symptoms.

BIOMEDICINES (2021)

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Article Cell Biology

Rhesus monkeys as a translational model for late-onset Alzheimer's disease

Dylan C. Souder et al.

Summary: Age is a major risk factor for late-onset Alzheimer's disease, and differences in the amyloid plaque microenvironment and the impact of AD pathology on local metabolism and inflammation vary among species, potentially explaining differences in neurodegeneration and functional decline. Using brain tissue from transgenic mice, rhesus monkeys, and human subjects, altered energetics in the plaque microenvironment were observed, highlighting the advantage of nonhuman primates in modeling the disease.

AGING CELL (2021)

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Article Cell Biology

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

Deyang Yu et al.

Summary: The study found that different branched-chain amino acids (BCAAs) have distinct metabolic effects, with low isoleucine diet improving hepatic insulin sensitivity and energy expenditure. It is suggested that reducing isoleucine may be a new approach to treating and preventing obesity and diabetes.

CELL METABOLISM (2021)

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Article Neurosciences

mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease

Candice E. Van Skike et al.

Summary: The study reveals that in an Alzheimer's disease model, mTOR drives impairments in neurovascular coupling (NVC) through inhibition of neuronal nitric oxide synthase (nNOS) and non-NOS-dependent components. However, attenuation of mTOR activity effectively restores NVC function and can even enhance it above normal responses. This suggests that targeting mTOR may be a potential treatment for Alzheimer's disease and other neurological diseases associated with aging.

JOURNAL OF NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology

David Baglietto-Vargas et al.

Summary: The researchers created a mouse model that expresses wildtype human A β, demonstrating effects on cognition, synaptic plasticity, brain changes, inflammation, PAS granules, and gene expression. Furthermore, excision of exon 14 through Cre-mediated methods reduced A β expression and rescued cognitive impairments.

NATURE COMMUNICATIONS (2021)

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Review Clinical Neurology

Anticancer drugs repurposed for Alzheimer's disease: a systematic review

Antonio Ancidoni et al.

Summary: The relationship between cancer and dementia has sparked interest in repurposing anticancer agents for Alzheimer's disease. Clinical trials testing approved anticancer drugs in AD show promise, but published studies on the topic have controversial findings. Larger and high-quality clinical trials are needed to confirm and extend the promising results from preclinical studies.

ALZHEIMERS RESEARCH & THERAPY (2021)

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Review Neurosciences

A Systematic Review of Glucose Transport Alterations in Alzheimer's Disease

Natalia Kyrtata et al.

Summary: Alzheimer's disease is associated with alterations in glucose transporters, possibly leading to reduced glucose transport across the blood-brain barrier and cell membranes, resulting in glucose deprivation and accelerated cognitive decline. Studies suggest that anti-diabetic medications show promise in improving glucose transport capacity in AD patients.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Neurosciences

A current view on Tau protein phosphorylation in Alzheimer's disease

Susanne Wegmann et al.

Summary: The functions of Tau in the central nervous system are regulated by various posttranslational modifications, with phosphorylation being widely recognized as a pathological hallmark in diseases like AD. However, the similarities and heterogeneity of phosphorylation patterns between physiological and pathological Tau make it challenging to identify specific modifications as therapeutic targets and biomarkers.

CURRENT OPINION IN NEUROBIOLOGY (2021)

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Article Neurosciences

Intranasal Paclitaxel Alters Alzheimer's Disease Phenotypic Features in 3xTg-AD Mice

Donna J. Cross et al.

Summary: Intranasally administered microtubule-stabilizing drugs, specifically paclitaxel, have shown promise in altering the phenotypic progression of Alzheimer's disease in 3xTg-AD mice. These drugs can increase axonal transport rates, reduce phospho-tau containing neurons, improve performance in behavioral tests, and decrease anxiety-related behaviors.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Review Biochemistry & Molecular Biology

The Amyloid-β Pathway in Alzheimer's Disease

Harald Hampel et al.

Summary: Breakthroughs in molecular medicine have highlighted the significance of the amyloid-beta pathway in the pathophysiology of Alzheimer's disease. Established biochemical alterations of the A beta cycle serve as promising targets for the development of disease-modifying therapies. Research indicates a crucial role of A beta pathway dyshomeostasis in the dynamics of AD pathophysiology, supporting the development of A beta-targeting therapeutic strategies for early treatment of AD.

MOLECULAR PSYCHIATRY (2021)

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Article Behavioral Sciences

Marked Mild Cognitive Deficits in Humanized Mouse Model of Alzheimer's-Type Tau Pathology

Joshua D. Cho et al.

Summary: While aged htau mice show a significant short-term spatial memory deficit, no major impairments in long-term learning and memory were found. Discrepancies in reported cognitive deficits within the literature may be attributed to differences in task difficulty and procedural details, highlighting the necessity for thorough characterization of behavioral deficits in AD mouse models before evaluating treatment efficacy.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)

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Review Neurosciences

Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

Zenghui Wei et al.

Summary: Alzheimer's disease is a chronic neurodegenerative disease that accounts for a majority of dementia cases and is one of the leading causes of death in the United States. Insulin resistance has been shown to play a significant role in the development of AD, with over 80% of patients also having type II diabetes, suggesting overlapping pathogenic mechanisms. Insulin resistance increases neuroinflammation, leading to amyloid beta-protein deposition and aberrant tau phosphorylation, ultimately contributing to the progression of AD.

FRONTIERS IN NEUROSCIENCE (2021)

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Review Biochemistry & Molecular Biology

Carnosine, Small but Mighty-Prospect of Use as Functional Ingredient for Functional Food Formulation

Ivana Jukic et al.

Summary: Carnosine is a dipeptide synthesized in the body with beneficial antioxidant properties, mainly found in the brain, muscle, and gastrointestinal tissues. Its component beta-alanine can serve as a dietary supplement to increase muscle carnosine and improve exercise effectiveness. While widely used among athletes, carnosine is less commonly utilized in cardiovascular or diabetic patients.

ANTIOXIDANTS (2021)

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Article Endocrinology & Metabolism

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Heidi H. Pak et al.

Summary: The study demonstrates that prolonged fasting plays a crucial role in the effects of calorie restriction on insulin sensitivity, fuel utilization, and aging in mice. Simply reducing caloric intake alone is not enough to replicate all these effects, highlighting the importance of daily prolonged fasting in regulating metabolic health and longevity.

NATURE METABOLISM (2021)

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Article Geriatrics & Gerontology

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging

Maria Conte et al.

Summary: FGF21, GDF15, and HN are mitokines related to mitochondrial stress and positively correlated with age, showing different expressions in type 2 diabetes and Alzheimer's disease, suggesting FGF21 as a candidate marker of healthy aging.

GEROSCIENCE (2021)

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Article Geriatrics & Gerontology

Next Generation Strategies for Geroprotection via mTORC1 Inhibition

Sabrina N. Dumas et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

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Article Cell Biology

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

Candice E. Van Skike et al.

AGING CELL (2020)

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Article Immunology

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer's disease mice

Yan Liu et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Neurosciences

A GLP-1/GIP/Gcg receptor triagonist improves memory behavior, as well as synaptic transmission, neuronal excitability and Ca2+ homeostasis in 3xTg-AD mice

Tian Li et al.

NEUROPHARMACOLOGY (2020)

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Article Biophysics

Progression of Alzheimer's disease and effect of scFv-h3D6 immunotherapy in the 3xTg-AD mouse model: An in vivo longitudinal study using Magnetic Resonance Imaging and Spectroscopy

J. Guell-Bosch et al.

NMR IN BIOMEDICINE (2020)

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Article Neurosciences

DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects

Gang Zhang et al.

NEUROSCIENCE BULLETIN (2020)

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Article Biochemistry & Molecular Biology

Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice

Tae-Woon Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Pharmacology & Pharmacy

Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation

Surabhi Shukla et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Clinical Neurology

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia A Randomized Clinical Trial

Suzanne Craft et al.

JAMA NEUROLOGY (2020)

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Review Cell Biology

Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes

Jeanne Guitton et al.

CELLS (2020)

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Article Geriatrics & Gerontology

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

Natalia Mota-Martorell et al.

GEROSCIENCE (2020)

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Article Clinical Neurology

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

Derek Kellar et al.

LANCET NEUROLOGY (2020)

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Article Biochemistry & Molecular Biology

Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice

Ying Zhou et al.

FASEB JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Type 2 Diabetes Mellitus Drugs for Alzheimer's Disease: Current Evidence and Therapeutic Opportunities

Lei Meng et al.

TRENDS IN MOLECULAR MEDICINE (2020)

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Review Geriatrics & Gerontology

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease

Felipe Salech et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Biochemistry & Molecular Biology

Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer's Disease

Tom L. Broderick et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice

Alejandro R. Roda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Neurosciences

Exercise-mediated alteration of hippocampal Dicer mRNA and miRNAs is associated with lower BACE1 gene expression and Aβ1-42 in female 3xTg-AD mice

Cory M. Dungan et al.

JOURNAL OF NEUROPHYSIOLOGY (2020)

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Article Endocrinology & Metabolism

Dietary Methionine Restriction Signals to the Brain Through Fibroblast Growth Factor 21 to Regulate Energy Balance and Remodeling of Adipose Tissue

Laura A. Forney et al.

OBESITY (2020)

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Article Multidisciplinary Sciences

Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model

Juan Jose Fernandez-Valenzuela et al.

SCIENTIFIC REPORTS (2020)

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Article Pharmacology & Pharmacy

Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer's Disease is Affected by A beta-ImmunoTherapy and Cognitive Stimulation

Alejandro R. Roda et al.

PHARMACEUTICS (2020)

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Article Medicine, Research & Experimental

Canagliflozin extends life span in genetically heterogeneous male but not female mice

Richard A. Miller et al.

JCI INSIGHT (2020)

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Article Clinical Neurology

Results from a pilot study: The effects of nicotinamide riboside on mild cognitive impairment

Miranda E. Orr et al.

Alzheimers & Dementia (2020)

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Article Neurosciences

Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement

Ruben Corpas et al.

MOLECULAR NEUROBIOLOGY (2019)

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Article Cell Biology

Rapamycin and Alzheimer's disease: Time for a clinical trial?

Matt Kaeberlein et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Editorial Material Cell Biology

Rapamycin and Alzheimer disease: a double-edged sword?

Julian M. Carosi et al.

AUTOPHAGY (2019)

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Article Neurosciences

Combined Effect of Fatty Diet and Cognitive Decline on Brain Metabolism, Food Intake, Body Weight, and Counteraction by Intranasal Insulin Therapy in 3xTg Mice

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Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

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IVIg protects the 3xTg-AD mouse model of Alzheimer's disease from memory deficit and Aβ pathology

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Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction

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High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

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p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

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Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration

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The fasting polypeptide FGF21 can enter brain from blood

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Zinc irreversibly damages major enzymes of energy production and antioxidant Defense prior to mitochondrial permeability transition

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Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

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Extension of chronological life span in yeast by decreased TOR pathway signaling

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Targeting the alpha 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

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Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease

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Tau suppression in a neurodegenerative mouse model improves memory function

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Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

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Calories do not explain extension of life span by dietary restriction in Drosophila

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Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo

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Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes?

E Steen et al.

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Cholinergic modulation of microglial activation by α7 nicotinic receptors

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Intravenous immunoglobulins containing antibodies against β-amyloid for the treatment of Alzheimer's disease

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Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

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Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Retinoic acid signaling in the nervous system of adult vertebrates

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Triple-transgenic model of Alzheimer's disease with plaques and tangles:: Intracellular Aβ and synaptic dysfunction

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Fast kinetics of taxol binding to microtubules -: Effects of solution variables and microtubule-associated proteins

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Will caloric restriction and folate protect against AD and PD?

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The role of insulin resistance in the pathogenesis of Alzheimer's disease - Implications for treatment

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CNS DRUGS (2003)

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

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Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease

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Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease

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Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial

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JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2001)

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The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse

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Review Medicine, General & Internal

Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus -: A meta-analysis of controlled clinical trials

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)

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Article Geriatrics & Gerontology

Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients

I Bourdel-Marchasson et al.

AGE AND AGEING (2001)

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Article Geriatrics & Gerontology

Quantitative assessment of possible age-related change in synaptic numbers in the human frontal cortex

SW Scheff et al.

NEUROBIOLOGY OF AGING (2001)

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Article Neurosciences

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Y Luo et al.

NATURE NEUROSCIENCE (2001)

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Article Clinical Neurology

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

E Masliah et al.

NEUROLOGY (2001)

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Article Biochemistry & Molecular Biology

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

T Nishimura et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2000)

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Article Biochemistry & Molecular Biology

β-amyloid1-42 binds to α7 nicotinic acetylcholine receptor with high affinity -: Implications for Alzheimer's disease pathology

HY Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Neurosciences

Endogenous mechanisms of neuroprotection: role of zinc, copper, and carnosine

MS Horning et al.

BRAIN RESEARCH (2000)

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Article Biochemistry & Molecular Biology

Amyloid peptide A beta(1-42) binds selectively and with picomolar affinity to alpha 7 nicotinic acetylcholine receptors

HY Wang et al.

JOURNAL OF NEUROCHEMISTRY (2000)

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