期刊
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
卷 44, 期 7, 页码 578-595出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/bkcs.12698
关键词
cyclization; homogeneous catalysis; insertion; isocyanide; multicomponent reaction
Isocyanides are widely used in organic synthesis to construct valuable chemical structures. The classical Ugi 4-component reaction is a robust method for synthesizing diversely functionalized peptoids. Various nitrogen heterocycles have been efficiently synthesized from commercially available compounds using established cyclization techniques. Transition metal-catalyzed processes and recently developed synthetic methods have enhanced the efficiency, availability, and novelty of isocyanide chemistry.
Isocyanides have been extensively utilized in organic synthesis to construct valuable chemical structures. Classical Ugi 4-component reaction is the robust method to access diversely functionalized peptoids. By using well-established cyclization techniques, a variety of nitrogen heterocycles from commercially accessible compounds have been efficiently synthesized. Several transition metal-catalyzed processes have been developed to utilize isocyanide as a useful carbonyl nitrogen synthon. Recently developed synthetic methods, such as C-H bond activation and visible-light photocatalysis, have been adopted to the isocyanide chemistry to enhance the efficiency, availability, and novelty of the chemical processes. This review summarizes the reactivity of isocyanide classified by the activation modes of electrophilic, nucleophilic, and radical species, together with the seminal discoveries and recent advances in the past 10 years.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据