Iron oxide nanoparticle biosynthesis and Potential application for hepatic cellular damages through antioxidant stress

The aim of this study was to produce Iron oxide nanoparticles by using environment friendly and cost-effective green synthesis method. In the present study, we use Artemisia scoparia leaves to prepare Artemisia scoparia-derived iron nanoparticles (AS-IONPs). The synthesized AS-IONPs were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD) analysis to investigate the crystalline structure and structural morphology of AS-IONPs. The antioxidant, cytotoxic, anti-hemolytic, and antibacterial potential of biosynthesized AS-IONPs was examined. AS-IONPs demonstrated excellent antioxidant potential with 27 mu g/mL and 29 mu g/mL IC50 against DPPH and ABTS assay that is due to numerous active compounds present in artemisia genus. AS-IONPs showed 76% cytotoxic effect against HepG2 cancer cell lines, and were also effective against erythrocyte damage. The in vitro antibacterial potential of AS-IONPs manifested that NPs showed lowest Minimum inhibitory concentration (MIC) at the concentration of 0.2 mg/mL, 0.35 mg/mL, and 0.7 mg/mL against different bacterial strains Escherichia coli, Bacillus brevis, and Staphylococcus aureus. Overall, these findings demonstrated the best possibility for the usage of AS-IONPs for treating variety of cancers and shows it to be a promising anticancer agent in the cancer therapeutics.

Automated summary

The aim of this study was to produce iron oxide nanoparticles via an environmentally friendly and cost-effective green synthesis method using Artemisia scoparia leaves. The synthesized AS-IONPs were characterized and found to have antioxidant, cytotoxic, anti-hemolytic, and antibacterial potential. AS-IONPs showed promising results in treating various cancers and exhibited excellent antioxidant properties and cytotoxic effects against cancer cell lines.