期刊
FOOD SCIENCE & NUTRITION
卷 11, 期 6, 页码 3141-3153出版社
WILEY
DOI: 10.1002/fsn3.3296
关键词
foam cells; MAPK signaling pathway; mulberry; NLRP3 inflammasome; restenosis
In this study, we found that NLRP3 inflammasome is significantly upregulated in restenosis and several restenosis-related DEGs are targets of mulberry extract. We demonstrated that mulberry extract suppresses the formation of ox-LDL-induced foam cells by upregulating cholesterol efflux genes ABCA1 and ABCG1, and dampens NLRP3 inflammasome activation through the MAPK signaling pathway. These findings reveal the therapeutic value of mulberry extract in neoatherosclerosis and restenosis treatment by regulating lipid metabolism and inflammatory response of foam cells.
The accumulation of foam cells in arterial intima and the accompanied chronic inflammation are considered major causes of neoatherosclerosis and restenosis. However, both the underlying mechanism and effective treatment for the disease are yet to be uncovered. In this study, we combined transcriptome profiling of restenosis artery tissue and bioinformatic analysis to reveal that NLRP3 inflammasome is markedly upregulated in restenosis and that several restenosis-related DEGs are also targets of mulberry extract, a natural dietary supplement used in traditional Chinese medicine. We demonstrated that mulberry extract suppresses the formation of ox-LDL-induced foam cells, possibly by upregulating the cholesterol efflux genes ABCA1 and ABCG1 to inhibit intracellular lipid accumulation. In addition, mulberry extract dampens NLRP3 inflammasome activation by stressing the MAPK signaling pathway. These findings unveil the therapeutic value of mulberry extract in neoatherosclerosis and restenosis treatment by regulating lipid metabolism and inflammatory response of foam cells.
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