BmCBP Catalyzes the Acetylation of BmApoLp-II Protein and Regulates Its Stability in Silkworm, Bombyx mori

Article Biochemistry & Molecular Biology

The Acetylation Modification of SP1 Regulates the Protein Stability in Silkworm

Zihan Sun et al.

Summary: This study reveals the mechanism of acetylation regulating the stability of silkworm SP1 protein, thereby affecting the nutrient storage and utilization of silkworm.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)

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Review Cell Biology

Modulation of cellular processes by histone and non-histone protein acetylation

Maria Shvedunova et al.

Summary: Lysine acetylation is a crucial protein post-translational modification that plays important roles in cellular and physiological processes. Lysine acetyltransferases and lysine deacetylases regulate gene expression and protein function by controlling acetylation and deacetylation.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Biochemical Research Methods

Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites

Jason C. Maynard et al.

Summary: O-GlcNAcylation, a widespread regulatory posttranslational modification, plays a role in response to nutritional status and stress, with dysregulation linked to various diseases. Advancements in enrichment and mass spectrometry techniques have accelerated research into this modification in recent years.

MOLECULAR & CELLULAR PROTEOMICS (2021)

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Systematic Proteome and Lysine Succinylome Analysis Reveals Enhanced Cell Migration by Hyposuccinylation in Esophageal Squamous Cell Carcinoma

Zhenchang Guo et al.

Summary: Esophageal squamous cell carcinoma (ESCC) is a aggressive malignancy with poor therapeutic outcomes. The alterations in proteins and posttranslational modifications (PTMs) leading to the pathogenesis of ESCC remain unclear. This study identifies abnormal protein and PTM pathways, including significantly downregulated lysine succinylation sites in cancer cells. Additionally, the restoration of succinylation inhibits cancer cell migration and negatively regulates histone methylation to promote cancer migration.

MOLECULAR & CELLULAR PROTEOMICS (2021)

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Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

Chen Huang et al.

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Analytical and Biochemical Perspectives of Protein O-GlcNAcylation

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Current development of CBP/p300 inhibitors in the last decade

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Theodora Myrto Perdikari et al.

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BIOPHYSICAL JOURNAL (2021)

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Design of genetically encoded sensors to detect nucleosome ubiquitination in live cells

Carolina dos Santos Passos et al.

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JOURNAL OF CELL BIOLOGY (2021)

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Article Microbiology

Comprehensive Succinylome Profiling Reveals the Pivotal Role of Lysine Succinylation in Energy Metabolism and Quorum Sensing of Staphylococcus epidermidis

Yiping Zhao et al.

Summary: This study provides the first comprehensive profile of succinylation in Staphylococcus epidermidis, highlighting the significant role succinylation may play in energy metabolism, quorum sensing system, and other bacterial behaviors. The findings offer new insights into the regulatory effects of succinylation on metabolic processes and may serve as a fundamental basis for further investigations on the mechanisms of colonization, virulence, and infection of S. epidermidis.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Systematic Analysis of the Lysine Crotonylome and Multiple Posttranslational Modification Analysis (Acetylation, Succinylation, and Crotonylation) in Candida albicans

Xiaowei Zhou et al.

Summary: The study conducted a large-scale analysis of crotonylated proteome in C. albicans, revealing numerous crotonylation sites and proteins. Functional analysis indicated that the majority of crotonylated proteins are associated with biosynthetic events and carbon metabolism. The protein-protein interaction network analysis suggested that proteins involved in ribosomal biogenesis, oxidative phosphorylation, nucleus activity, and proteasome formation are heavily modified by multiple PTM types.

MSYSTEMS (2021)

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Correction Biochemistry & Molecular Biology

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes (vol 38, pg 4958, 2010)

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The effect of acetylation on the protein stability of BmApoLp-III in the silkworm, Bombyx mori

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INSECT MOLECULAR BIOLOGY (2020)

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The stability and antiapoptotic activity of Bm30K-3 can be improved by lysine acetylation in the silkworm, Bombyx mori

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20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori

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INSECT MOLECULAR BIOLOGY (2020)

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Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation

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Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

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CELL (2020)

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Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against Atherosclerosis and Diabetes

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Functions and mechanisms of non-histone protein acetylation

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Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

Brian T. Weinert et al.

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Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F-box protein subunit

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FASEB JOURNAL (2018)

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Correction Multidisciplinary Sciences

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage specific tumours (vol 550, pg 128, 2017)

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Lysine acetylation stabilizes SP2 protein in the silkworm Bombyx mori

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Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

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Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence

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Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

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EMBO JOURNAL (2015)

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Comprehensive profiling of lysine acetylation suggests the widespread function is regulated by protein acetylation in the silkworm, Bombyx mori

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Silkworm Apolipophorin Protein Inhibits Hemolysin Gene Expression of Staphylococcus aureus via Binding to Cell Surface Lipoteichoic Acids

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Acetyl-CoA Carboxylase Regulates Global Histone Acetylation

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Involvement of apolipophorin III in antibacterial defense of Galleria mellonella larvae

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Silkworm Apolipophorin Protein Inhibits Staphylococcus aureus Virulence

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Expression Analysis and Characteristics of Profilin Gene from Silkworm, Bombyx mori

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Mechanism by which Bombyx mori hemocytes recognize microorganisms: direct and indirect recognition systems for PAMPs

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Regulation of the p300 HAT domain via a novel activation loop

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Inhibition of apoptosis by recombinant 30K protein originating from silkworm hemolymph

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BmCBP Catalyzes the Acetylation of BmApoLp-II Protein and Regulates Its Stability in Silkworm, Bombyx mori

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